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A006 – Inflammation

Area coordinator

José Ramón González Juanatey

Research objectives

The main purpose of the Inflammation area is to seek new therapeutic targets and improve clinical and therapeutic management strategies.

  • Studying the effects of adipokines and metabolic hormones in the regulation of viability, metabolism and autophagic processes in in vivo and in vitro human and murine cardiomyocytes.
  • Studying the connection between cardiac and plasmatic levels of adipokines and metabolic hormones, body composition and risk and prognostic markers in cardiovascular pathologies in patients with cardiovascular risk (metabolic syndrome) and in patients with an established cardiovascular disease (cardiac insufficiency), with the purpose of helping establish the validity of adipokines and metabolic hormones as new biomarkers both in metabolic syndromes and in established cardiovascular diseases.
  • Studying adipokines as potential new disease biomarkers and biomarkers of response to treatment in patients suffering from rheumatoid arthritis.
  • Usefulness of pleural liquid analysis in the diagnosis of pleural effusions. Studying the effects of adipokines on specific transcription factors and autophagy regulation mechanisms.
  • Identifying and characterizing new adipokines in musculoskeletical system cells (cartilage, synovium, muscle, bone, periarticular adipose tissue).
  • Carrying out thoracic ultrasound scans to identify a trapped lung before thoracic drainage.
  • Studying the effect of drugs used in Cardiovascular and Nutraceutical Medicine at a cardiomyocyte level.
  • Studying the pharmacological effects of micronutrients of the polyphenol fraction of extra virgin olive oil.
  • Searching parameters (clinical and/or biological parameters) which identify different types of responses from the pleura.
  • Studying the physiopathogenic mechanisms of rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus and osteoporosis).
  • Identifying and validating new therapeutic targets in rheumatoid arthritis.
  • Identifying and validating biomarkers of response to treatment in patients suffering from rheumatoid arthritis.
  • Identifying and characterizing genetic factors of susceptibility to arthrosis.
  • Characterizing genetic factors of susceptibility to systemic lupus erythematosus and its relation to clinical susceptibility, as well as its variability in the European population.
  • Interaction between immune system and musculoskeletical system: role of adipokines in the modulation of regulatory T cells (Treg) and other lymphocyte subpopulations.

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