{"id":18967,"date":"2022-01-18T15:34:37","date_gmt":"2022-01-18T14:34:37","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e048-gastroenterologia-molecular-y-celular\/"},"modified":"2026-01-23T14:45:29","modified_gmt":"2026-01-23T13:45:29","slug":"e048-gastroenterologia-molecular-y-celular","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/e048-gastroenterologia-molecular-y-celular\/","title":{"rendered":"E048 &#8211; Molecular and Cellular Gastroenterology"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u00c1REA: <a href=\"https:\/\/www.idisantiago.es\/en\/research-areas-2\/a007-infectology-inflammation-and-vaccines\/\">INFECTOLOGY, INFLAMMATION AND VACCINES<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2021\/11\/grupo_investigacion.jpg&#8221; title_text=&#8221;Corporate portrait of office workers and employees&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Objectives and lines of research&#8221; admin_label=&#8221;Objetivos y l\u00edneas de investigaci\u00f3n&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Objectives<\/h3>\n<p>Our research group focuses on the study of new mechanisms involved in the development of chronic diseases that affect the digestive tract. In particular, we have great interest in the search for new therapeutic targets for inflammatory bowel disease.<\/p>\n<h3>Lines of research<\/h3>\n<ul>\n<li>Characterization and validation of biomarkers for the response to biologic treatments in patients with inflammatory bowel disease.<\/li>\n<li>Study of inflammation resolution mechanisms.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Research team&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<table style=\"width: 100.628%; border-collapse: collapse; border-style: hidden; height: 104px;\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\"><strong>Leader<\/strong><br \/>Conde Aranda, Javier<\/td>\n<td style=\"width: 50%;\">\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Members<\/strong><br \/>Ait Eldjoudi, Djedjiga<br \/>Arosa Garc\u00eda, Laura<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Projects&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<strong>Generaci\u00f3n de un nuevo modelo de predicci\u00f3n y\/o respuesta para el tratamiento con ustekinumab en pacientes con enfermedad inflamatoria intestinal<\/strong><br \/>Entidad financiadora: Xunta de Galicia<br \/>Duraci\u00f3n: 2022-2024<br \/>Cuant\u00eda: 65000 EUR<br \/>Investigador\/a principal: <a href=\"https:\/\/www.idisantiago.es\/en\/team\/javier-conde-aranda\/\">Javier Conde Aranda<\/a> <br \/><\/p>\n<p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publications&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Sara Mart\u00ednez Ramos; Carlos Rafael Vidal; Beatriz Malvar Fern\u00e1ndez; \u00c1ngela Rodr\u00edguez Trillo; Douglas Veale; Ursula Fearon; Carmen Conde; Javier Conde Aranda; Timothy RDJ Radstake; Jose Mar\u00eda Pego-Reigosa; Kris A Reedquist; Samuel Garc\u00eda.<strong> HOXA5 is a key regulator of class 3 semaphorins expression in the synovium of rheumatoid arthritis patients. <\/strong><em>Rheumatology<\/em><strong>,<\/strong> 2022 Nov 18:keac654. <span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1093\/rheumatology\/keac654\"><strong>doi: 10.1093\/rheumatology\/keac654.<\/strong><\/a><\/span><\/li>\n<li>Morena Scotece, Javier Conde-Aranda. <strong>Inflammation in Health and Disease: New Insights and Therapeutic Avenues.<\/strong> <em>Int J Mol Sci.<\/em> 2022 Jul 29;23(15):8392. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.3390\/ijms23158392\">doi: 10.3390\/ijms23158392<\/a><\/strong><\/span>.<\/li>\n<li>Laura Arosa, Miguel Camba-G\u00f3maz, Javier Conde-Aranda. <strong>Neutrophils in Intestinal Inflammation: What We Know and What We Could Expect for the Near Future<\/strong>. <em>Gastrointestinal Disorders<\/em>, 2022 4(4): 263-276.<span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.3390\/gidisord4040025\"> doi: 10.3390\/gidisord4040025.<\/a><\/strong><\/span><\/li>\n<li>\u00a0Javier Conde,\u00a0Isabel Fern\u00e1ndez-Pisonero,\u00a0Myriam Cuadrado,\u00a0Antonio Abad,\u00a0Javier Robles-Valero,\u00a0Xos\u00e9 R Bustelo.\u00a0<span lang=\"EN-US\"><strong>Distinct Roles of Vav Family Members in Adaptive and Innate\u00a0Immune Models of Arthritis.<\/strong>\u00a0<\/span><span lang=\"EN-US\"><em>Biomedicines<\/em>.\u00a02021 Jun 19;9(6):695.<\/span><span lang=\"EN-US\">\u00a0<\/span><span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.3390\/biomedicines9060695\"><span lang=\"EN-US\">doi: 10.3390\/biomedicines9060695.<\/span><\/a><\/strong><\/span><\/li>\n<li>Egle Katkeviciute, Larissa Hering, Ana Montalban-Arques, Philipp Busenhart, Marlene Schwarzfischer, Roberto Manzini,\u00a0Javier Conde, Kirstin Atrott, Silvia Lang, Gerhard Rogler, Elisabeth Naschberger, Vera S Schellerer, Michael St\u00fcrzl, Andreas Rickenbacher, Matthias Turina, Achim Weber, Sebastian Leibl, Gabriel E Leventhal, Mitchell Levesque, Onur Boyman, Michael Scharl, Marianne R Spalinger.<strong> Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development.<\/strong><em> J Clin Invest.<\/em> 2021 Jan 4;131(1):e140281. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1172\/JCI140281\">doi: 10.1172\/JCI140281.<\/a><\/strong><\/span><\/li>\n<li>Javier Conde, Clara Ruiz-Fernandez, Vera Francisco, Morena Scotece, Rodolfo Gomez, Francisca Lago, Miguel Angel Gonzalez -Gay, Jesus Pino, Ali Mobasheri, Oreste Gualillo. <strong>Dickkopf-3 (DKK3) Signalling in IL-1a-Challenged Chondrocytes: Involvement of the NF-kB Pathway.<\/strong> <em>Cartilage<\/em>. 2020 Jun 12. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1177\/1947603520933328\">doi: 10.1177\/1947603520933328<\/a><\/strong><\/span>.<\/li>\n<li>L. Francisco Lorenzo-Mart\u00edn, Carmen Citterio, Mauricio Menacho-M\u00e1rquez, Javier Conde, Romain M. Larive, Sonia Rodr\u00edguez-Fdez, Ram\u00f3n Garc\u00eda-Escudero, Javier Robles-Valero, Myriam Cuadrado, Isabel Fern\u00e1ndez-Pisonero, Mercedes Dosil, Mar\u00eda A. Sevilla, Mar\u00eda J. Montero, Pedro M. Fern\u00e1ndez-Salguero, Jes\u00fas M. Paramio, Xos\u00e9 R. Bustelo. <strong>Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms.<\/strong> <em>Oncogene<\/em>. 2019 Jan;38(2):209-227. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1038\/s41388-018-0433-7\">doi:10.1038\/s41388-018-0433-7<\/a><\/strong><\/span>.<\/li>\n<li>Javier Conde, Miguel Otero, Morena Scotece, Vanessa Abella, Rodolfo Gomez, Veronica Lopez, Jesus Pino, Antonio Mera, Mary B Goldring, Oreste Gualillo. <strong>E74-Like Factor (ELF3) and Leptin, a Novel Loop Between Obesity and Inflammation Perpetuating a Pro-Catabolic State in Cartilage.<\/strong> <em>Cellular Physiology and Biochemistry<\/em>. 2018 Mar 13,45(6):2401-2410. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1159\/000488227\">doi: 10.1159\/000488227<\/a><\/strong><\/span>.<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Web del grupo&#8221; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]https:\/\/[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Lead researcher<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-11087\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"18793\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/en\/team\/javier-conde-aranda\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"18793\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Javier-Conde-Aranda-320x320.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Javier-Conde-Aranda-320x320.jpg\" alt=\"Javier Conde Aranda\" width=\"320\" height=\"320\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tJavier Conde Aranda\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>jcondearanda@outlook.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-phone\">\n<i class=\"fa fa-phone\"><\/i>\t<a href=\"#0\"  class=\"\" >\n\t\t<span>(+34) 981 955 920<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-website\">\n<i class=\"fa fa-globe\"><\/i>\t<a href=\"http:\/\/orcid.org\/0000-0002-2187-479X\"  class=\"\" target=\"_blank\">\n\t\t<span>http:\/\/orcid.org\/0000-0002-2187-479X<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/en\/team\/javier-conde-aranda\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: INFECTOLOGY, INFLAMMATION AND VACCINESObjectives Our research group focuses on the study of new mechanisms involved in the development of chronic diseases that affect the digestive tract. In particular, we [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":16366,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[844],"project_tag":[],"class_list":["post-18967","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-infectologia-en"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/18967","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/comments?post=18967"}],"version-history":[{"count":18,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/18967\/revisions"}],"predecessor-version":[{"id":44570,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/18967\/revisions\/44570"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/media\/16366"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/media?parent=18967"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project_category?post=18967"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project_tag?post=18967"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}