{"id":18969,"date":"2022-01-18T15:28:52","date_gmt":"2022-01-18T14:28:52","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e038-patologia-musculoesqueletica\/"},"modified":"2026-01-22T13:45:01","modified_gmt":"2026-01-22T12:45:01","slug":"e038-patologia-musculoesqueletica","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/e038-patologia-musculoesqueletica\/","title":{"rendered":"E038 &#8211; Musculoskeletal Pathology"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.17.6&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]\u00c1REA: <a href=\"https:\/\/www.idisantiago.es\/en\/research-areas-2\/a007-infectology-inflammation-and-vaccines\/\">INFECTOLOG\u00cdA, INFLAMACI\u00d3N Y VACUNAS<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Grupo-E038-scaled.jpg&#8221; title_text=&#8221;Grupo E038&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Objectives and lines of research&#8221; admin_label=&#8221;Objetivos y l\u00edneas de investigaci\u00f3n&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Objectives<\/h3>\n<p>The objective of the different lines of research of the Musculoskeletal Pathology Group are the diseases that most prevalently affect the locomotor system. These pathologies include osteoarthritis, osteoporosis, heterotopic ossification, ankylosing spondylitis, gout, etc.<br \/>We do patient-oriented research.<\/p>\n<h3>Lines of research<\/h3>\n<p>The lines of the laboratory can be grouped into 5 large areas of knowledge:<\/p>\n<ul>\n<li>New pharmacological approaches for osteoarthritis and other rheumatic inflammatory diseases.<\/li>\n<li>Study and pharmacological modulation of bone metabolism.<\/li>\n<li>Search for protein and cellular biomarkers for the characterization and diagnosis of heterotopic ossification.<\/li>\n<li>Pharmacological doping of implants for the surgical approach of pathologies such as osteoarthritis.<\/li>\n<li>Study of environmental, iatrogenic or metabolic factors harmful to the musculoskeletal system.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Research team&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<table style=\"width: 100%; border-collapse: collapse; border-style: hidden; height: 417px;\" border=\"0\">\n<tbody>\n<tr style=\"height: 417px;\">\n<td style=\"width: 50%; height: 417px;\">\n<p><strong>Leader<\/strong><br \/>G\u00f3mez Bahamonde, Rodolfo<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Members<\/strong><br \/>Alonso P\u00e9rez, Ana<br \/>Amhaz Escanlar, Samer<br \/>Bravo L\u00f3pez, Susana Bel\u00e9n<br \/>Crespo Golmar, Ant\u00eda<br \/>Crugeiras Sampedro, Mar\u00eda<br \/>Fern\u00e1ndez Fern\u00e1ndez, David<br \/>Guill\u00e1n Fresco, Mar\u00eda<br \/>Jorge Barreiro, Francisco Javier<br \/>Jorge Mora, Alberto Agust\u00edn<br \/>Jorge Mora, Mar\u00eda Teresa<br \/>Lois Iglesias, Ana Josefina<br \/>L\u00f3pez Fag\u00fandez, Miriam<\/p>\n<\/td>\n<td style=\"width: 50%; height: 417px;\">\n<p>L\u00f3pez L\u00f3pez, Ver\u00f3nica<br \/>Misa Agusti\u00f1o, Mar\u00eda Jos\u00e9<br \/>N\u00fa\u00f1ez Gonz\u00e1lez, Cristina<br \/>Pazos P\u00e9rez, Andr\u00e9s<br \/>Pena Pena, Carmen<br \/>Pi\u00f1eiro Ramil, Mar\u00eda<br \/>Su\u00e1rez Rodr\u00edguez, Ana<br \/>Zas Veiga, Lorena<\/p>\n<p>&nbsp;<\/p>\n<p><strong>External Collaborators Staff<\/strong><br \/>Pazos P\u00e9rez, Sabela<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Proyectos&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publications&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.18.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Eloi Franco-Trepat, Ana Alonso-P\u00e9rez, Mar\u00eda Guill\u00e1n-Fresco, Alberto Jorge-Mora, Antia Crespo-Golmar, Miriam L\u00f3pez-Fag\u00fandez, Andr\u00e9s Pazos-P\u00e9rez, Oreste Gualillo, Susana Bel\u00e9n Bravo, Rodolfo G\u00f3mez Bahamonde. <strong>Amitriptyline blocks innate immune responses mediated by toll-like receptor 4 and IL-1 receptor: Preclinical and clinical evidence in osteoarthritis and gout.<\/strong> <em>Br J Pharmacol<\/em>. 2022;179:270\u2013286. <strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1111\/bph.15707\">doi: 10.1111\/bph.15707<\/a><\/span>\u00a0<\/strong><\/li>\n<li>Mar\u00eda Guill\u00e1n-Fresco, Eloi Franco-Trepat, Ana Alonso-P\u00e9rez, Alberto Jorge-Mora, Miriam L\u00f3pez-Fag\u00fandez, Andr\u00e9s Pazos-P\u00e9rez, Oreste Gualillo and Rodolfo G\u00f3mez.<strong> Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition<\/strong>.<em> J. Clin. Med.<\/em> 2020, 9(4), 1163.<span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.3390\/jcm9041163\"><strong> doi: 10.3390\/jcm9041163\u00a0<\/strong><\/a><\/span><\/li>\n<li>Eloi Franco-Trepat, Mar\u00eda Guill\u00e1n-Fresco, Ana Alonso-P\u00e9rez, Alberto Jorge-Mora, Vera Francisco, Oreste Gualillo and Rodolfo G\u00f3mez. <strong>Visfatin Connection: Present and Future in Osteoarthritis and Osteoporosis.<\/strong><em> J. Clin. Med<\/em>. 2019, 8(8), 1178; <a href=\"https:\/\/doi.org\/10.3390\/jcm8081178\"><span style=\"color: #808000;\"><strong>doi: 10.3390\/jcm8081178\u00a0<\/strong><\/span><\/a><\/li>\n<li>Eloi Franco-Trepat, Ana Alonso-P\u00e9rez, Mar\u00eda Guill\u00e1n-Fresco, Alberto Jorge-Mora, Oreste Gualillo, Juan J. G\u00f3mez-Reino &amp; Rodolfo G\u00f3mez Bahamonde\u00a0 <strong>Visfatin as a therapeutic target for rheumatoid arthritis,<\/strong><em> Expert Opinion on Therapeutic Targets<\/em>, 2019, 23:7, 607-618, <a href=\"https:\/\/doi.org\/10.1080\/14728222.2019.1617274\"><span style=\"color: #808000;\"><strong>doi: 10.1080\/14728222.2019.1617274<\/strong><\/span><\/a><\/li>\n<li>Alberto Jorge-Mora, Samer Amhaz-Escanlar, Sabela Fern\u00e1ndez-Pose, Cristina Lope-del-Teso, Jes\u00fas Pino-M\u00ednguez, Jos\u00e9 Ram\u00f3n Caeiro-Rey, Juan Pretell-Mazzini, Rodolfo G\u00f3mez. <strong>Early outcomes of locked noncemented stems for the management of proximal humeral fractures: a comparative study.<\/strong><em> Journal of Shoulder and Elbow Surgery,<\/em> 2019, 28:1, 48 &#8211; 55.<span style=\"color: #808000;\"> <a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.jse.2018.05.036\"><strong>doi: 10.1016\/j.jse.2018.05.036<\/strong><\/a><\/span><\/li>\n<li>Alberto Jorge-Mora, Naroa Imaz, Eva Garcia-Lecina, Gerard M. O&#8217;Connor, Rodolfo G\u00f3mez-Vaamonde, Ana Alonso-P\u00e9rez, Eloi Franco-Trepat, Carlota Garc\u00eda-Santiago, Jes\u00fas Pino-Minguez, Daniel Nieto. <strong>In vitro response of bone marrow mesenchymal stem cells (hBMSCs) on laser-induced periodic surface structures for hard tissue replacement: Comparison between tantalum and titanium<\/strong>. <em>Optics and Lasers in Engineering<\/em>, 2018, 111, 34-41. <span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.optlaseng.2018.07.008.\"><strong>doi: 10.1016\/j.optlaseng.2018.07.008<\/strong><\/a><\/span><\/li>\n<li>Alonso-P\u00e9rez A, Franco-Trepat E, Guill\u00e1n-Fresco M, Jorge-Mora A, L\u00f3pez V, Pino J, Gualillo O and G\u00f3mez R. <strong>Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function.<\/strong> <em>Front. Physiol.<\/em>, 2018, 9:504. <span style=\"color: #808000;\"><strong>doi: 10.3389\/fphys.2018.00504<\/strong><\/span><\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Group website&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.18.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"Ri41ZnT8Uy\"><p><a href=\"https:\/\/mpgroup.es\/\">Home<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"\u00abHome\u00bb \u2014 Musculoskeletal Patology Group\" src=\"https:\/\/mpgroup.es\/embed\/#?secret=3YzOjjDGCg#?secret=Ri41ZnT8Uy\" data-secret=\"Ri41ZnT8Uy\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Lead researcher<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-11072\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"18794\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/en\/team\/rodolfo-gomez-bahamonde\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"18794\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Rodolfo-Gomez-Bahamonde-320x320.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Rodolfo-Gomez-Bahamonde-320x320.jpg\" alt=\"Rodolfo G\u00f3mez Bahamonde\" width=\"320\" height=\"320\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tRodolfo G\u00f3mez Bahamonde\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>contacto@mpgroup.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-phone\">\n<i class=\"fa fa-phone\"><\/i>\t<a href=\"#0\"  class=\"\" >\n\t\t<span>(+34) 981 955 704<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-website\">\n<i class=\"fa fa-globe\"><\/i>\t<a href=\"https:\/\/orcid.org\/0000-0002-1309-1023\"  class=\"\" target=\"_blank\">\n\t\t<span>https:\/\/orcid.org\/0000-0002-1309-1023<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/en\/team\/rodolfo-gomez-bahamonde\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: INFECTOLOG\u00cdA, INFLAMACI\u00d3N Y VACUNASObjectives The objective of the different lines of research of the Musculoskeletal Pathology Group are the diseases that most prevalently affect the locomotor system. These pathologies [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":12346,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[844],"project_tag":[],"class_list":["post-18969","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-infectologia-en"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/18969","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/comments?post=18969"}],"version-history":[{"count":24,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/18969\/revisions"}],"predecessor-version":[{"id":44544,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/18969\/revisions\/44544"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/media\/12346"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/media?parent=18969"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project_category?post=18969"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project_tag?post=18969"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}