{"id":18971,"date":"2022-01-18T15:23:07","date_gmt":"2022-01-18T14:23:07","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e009-cardiologia-celular-y-molecular\/"},"modified":"2026-02-27T11:14:08","modified_gmt":"2026-02-27T10:14:08","slug":"e009-cardiologia-celular-y-molecular","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/e009-cardiologia-celular-y-molecular\/","title":{"rendered":"E009 – Cellular and Molecular Cardiology"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.16″ _module_preset=”default” width=”100%” custom_padding=”0px||||false|false” locked=”off” collapsed=”on” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”]\u00c1REA: CARDIOVASCULAR<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ _module_preset=”default” width=”100%” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/01\/cardiomiocitos-E009.jpg” title_text=”cardiomiocitos E009″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_toggle title=”Objectives and lines of research” admin_label=”Objetivos y l\u00edneas de investigaci\u00f3n” _builder_version=”4.19.4″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”]<\/p>\n

Objectives<\/h3>\n

1.- Contribute to the development of future “precision” therapies for heart failure by studying the specific pathophysiological alterations that characterize the different phenotypes of patients with this pathology. Heart failure represents an important socio-sanitary problem due to its high prevalence, high hospitalization and mortality rates, and significant health costs. It comprises a heterogeneous group of syndromes with complex and not fully known pathophysiological mechanisms, and different clinical presentation and response to treatment. The specific objectives of our work include the analysis of the metabolic profiles of the cardiac tissue of patients with different phenotypes of heart failure, the identification of new metabolic and inflammatory pathophysiological mediators in these patients, and the in vivo and in vitro study of alterations in the metabolic pathways that characterize the different phenotypes of this disease, in order to help identify and validate new, more specific and adapted therapeutic targets.
2.-Investigate new effects at the cardiomyocyte and cardiometabolic level of the most promising drugs for the treatment of heart failure at present (inhibitors of sodium-glucose cotransporter type 2, stimulators of soluble guanylate cyclase and dual inhibitors of angiotensin II receptor and neprilysin).<\/p>\n

Lines of research<\/h3>\n

1.-Study of mitochondrial dysfunction and changes in cardiac metabolism in heart failure.
2.-Possible new effects of the neprilysin and valsartan inhibitor LCZ696 on the regulation of viability and cardiomyocyte metabolism.
3.-Analysis of the effects of the SGLT2 inhibitor empagliflozin on the regulation of energy metabolism in cardiac, hepatic and visceral adipose tissue.<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”Research team” admin_label=”Equipo investigador” _builder_version=”4.21.0″ _module_preset=”default” body_font=”|300|||||||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n\n\n\n
Leader<\/strong>
Lago Paz, Francisca<\/p>\n

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Coleader\u00a0<\/strong>
Arag\u00f3n Herrera, Alana<\/p>\n

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Members<\/strong>
Anido Varela, Laura
Arufe Manteiga, Mar\u00eda Isabel
Bastos Fern\u00e1ndez, Mar\u00eda
de la Fuente L\u00f3pez, Pablo
D\u00edaz Fern\u00e1ndez, Brais
Dur\u00e1n Mu\u00f1oz, Dar\u00edo
Garc\u00eda Seara, Francisco Javier
G\u00f3mez Cibeira, Luc\u00eda
Mart\u00ednez Rey, Mar\u00eda del Carmen
Minguito Carazo, Carlos
Otero Garc\u00eda, \u00d3scar
Otero Santiago, Manuel Francisco
Pazos V\u00e1zquez, Cristina
Rodr\u00edguez Penas, Diego
V\u00e1zquez Abu\u00edn, Xocas<\/p>\n

External collaborator staff<\/strong>
Bouza Pad\u00edn, Rebeca
Feij\u00f3o Band\u00edn, Sandra
Taboada Lucero, Arturo Ignacio<\/p>\n

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