{"id":18972,"date":"2022-01-18T15:20:34","date_gmt":"2022-01-18T14:20:34","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e001-genetica-cardiovascular\/"},"modified":"2024-09-10T13:51:10","modified_gmt":"2024-09-10T11:51:10","slug":"e001-genetica-cardiovascular","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/e001-genetica-cardiovascular\/","title":{"rendered":"C048 &#8211; Cardiovascular Genetics"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]\u00c1REA: <a href=\"https:\/\/www.idisantiago.es\/areas-de-investigacion\/a006-cardiovascular\/\">CARDIOVASCULAR<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2021\/11\/grupo_investigacion.jpg&#8221; title_text=&#8221;Corporate portrait of office workers and employees&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Objectives and lines of research&#8221; admin_label=&#8221;Objetivos y l\u00edneas de investigaci\u00f3n&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Objectives<\/h3>\n<p>The main objective is the knowledge of the genetic bases of cardiovascular disease in general, focusing mainly on:<br \/>&#8211; Genetics of familial heart disease<br \/>&#8211; Genetics of chemotherapy-induced cardiotoxicity<br \/>&#8211; Genetics of common cardiovascular disease<br \/>&#8211; Pharmacogenetics of flecainide in atrial fibrillation<\/p>\n<h3>Lines of research<\/h3>\n<ul>\n<li>Genetics of familial heart disease: improving genetic diagnosis<\/li>\n<li>Genetic evaluation of chemotherapy-induced cardiotoxicity<\/li>\n<li>Pharmacogenetics of flecainide in patients with atrial fibrillation<\/li>\n<li>Search for genetic risk variation in common cardiovascular disease<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Research team&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<table style=\"width: 100%; border-collapse: collapse; border-style: hidden;\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\">\n<p><strong>Leader<\/strong><br \/>Bri\u00f3n Mart\u00ednez, Mar\u00eda Jos\u00e9<\/p>\n<p><strong>Members<\/strong><br \/>Adega Pico, Alba<br \/>\u00c1lvarez Barredo, Mar\u00eda<br \/>Blanco Verea, Alejandro Jos\u00e9<br \/>Caaveiro Saavedra, Zoila<br \/>Gil Torres, Roc\u00edo<br \/>L\u00f3pez Abel, Bernardo<br \/>L\u00f3pez Trigo, Nuria<br \/>Ramos Luis, Eva<br \/>S\u00e1nchez Carmona, Estrella del Roc\u00edo<\/p>\n<\/td>\n<td style=\"width: 50%;\">\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Projects&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publications&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Escobar-Lopez L, Ochoa JP, Mirelis JG, Espinosa M\u00c1, Navarro M, Gallego-Delgado M, Barriales-Villa R, Robles-Mezcua A, Basurte-Elorz MT, Guti\u00e9rrez Garc\u00eda-Moreno L, Climent V, Jim\u00e9nez-Jaimez J, Mogoll\u00f3n-Jim\u00e9nez MV, Lopez J, Pe\u00f1a-Pe\u00f1a ML, Garc\u00eda-\u00c1lvarez A, Brion M, Ripoll-Vera T, Palomino-Doza J, Tir\u00f3n C, Idiazabal U, Br\u00f6gger MN, Garc\u00eda-Hern\u00e1ndez S, Restrepo-C\u00f3rdoba MA, Gonzalez-Lopez E, M\u00e9ndez I, Sabater M, Villacorta E, Larra\u00f1aga-Moreira JM, Abecia A, Fern\u00e1ndez AI, Garc\u00eda-Pinilla JM, Rodr\u00edguez-Palomares JF, Gimeno-Blanes JR, Bayes-Genis A, Lara-Pezzi E, Dom\u00ednguez F, Garcia-Pavia P. <strong>Association of Genetic Variants With Outcomes in Patients With Nonischemic Dilated Cardiomyopathy<\/strong>. <em>J Am Coll Cardio<\/em> . 2021;78(17):1682-1699. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.jacc.2021.08.039\">doi: 10.1016\/j.jacc.2021.08.039<\/a><\/strong><\/span><\/li>\n<li>Akira Mori A, Reinel de Castro, Hernandes Bortolin R, Medeiros Bastos G, Fernandes de Oliveira V, Monteiro Ferreira G, Dominguez Crespo Hirata T, Moreno Fajardo C, Ferraz Sampaio M, Ribeiro Moreira DA, Pachon-Mateos JC, de Barros Correia E, Guerra de Moraes Rego Sousa A, Brion M, Carracedo A, Dominguez Crespo Hirata R, Hiroyuki Hirata M. <strong>Association of variants in MYH7, MYBPC3 and TNNT2 with sudden cardiac death-related risk factors in Brazilian patients with hypertrophic cardiomyopathy<\/strong>. <em>FSI Genet<\/em>. 2021; 52:102478. <span style=\"color: #808000;\"><strong>doi<span class=\"identifier doi\"><span class=\"id-label\">: <\/span><a class=\"id-link\" style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.fsigen.2021.102478\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"DOI\">10.1016\/j.fsigen.2021.102478<\/a><\/span><\/strong><\/span><\/li>\n<li>Eiras S, \u00c1lvarez E, Bri\u00f3n M, Gonz\u00e1lez-Juanatey JR. <strong>COVID-19 and treatment guided by biochemical and molecular diagnostic tests to reduce myocardial damage and cardiotoxicity<\/strong>. <em>Rev Esp Cardiol (Engl Ed)<\/em>. 2020;73(8):691-693. <strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.rec.2020.05.009\">doi: 10.1016\/j.rec.2020.05.009<\/a><\/span><\/strong><\/li>\n<li>Grassi S, Campuzano O, Coll M, Bri\u00f3n M, Arena V, Iglesias A; Carracedo A, Brugada R, Oliva A. <strong>Genetic variants of uncertain significance: how to match scientific rigour and standard of proof in sudden cardiac death?.<\/strong> <em>Leg Med (Tokyo)<\/em>. 2020 Apr 23;45:101712. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.legalmed.2020.101712\">doi:10.1016\/j.legalmed.2020.101712<\/a><\/strong><\/span><\/li>\n<li>Brion M, Gonz\u00e1lez-Juantey JR, Carracedo A. <strong>Polygenic risk score as a key factor in cardiovascular clinical prediction models.<\/strong> <em>Rev Esp Cardiol (Engl Ed)<\/em>. 2020; pii: S1885-5857(20)30032-3. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.rec.2020.01.003\">doi: 10.1016\/j.rec.2020.01.003 <\/a><\/strong><\/span><\/li>\n<li>Santori M, Gil R, Blanco-Verea A, Riur\u00f3 H, D\u00edaz-Castro \u00d3, L\u00f3pez-Abel B, Brugada R, Carracedo \u00c1, P\u00e9rez GJ, Scornik FS, Brion M. <strong>Sudden infant death as the most severe phenotype caused by genetic modulation in a family with atrial fibrillation.<\/strong> <em>Forensic Sci Int Genet.<\/em> 2019; 43:102159. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.fsigen.2019.102159\">doi: 10.1016\/j.fsigen.2019.102159<\/a><\/strong><\/span><\/li>\n<li>Martinez-Matilla M, Blanco-Verea A, Santori M, Ansede-Bermejo J, Ramos-Luis E, Gil R, Bermejo AM, Lotufo-Neto F, Hirata MH, Brisighelli F, Paramo M, Carracedo A, Brion M. <strong>Genetic susceptibility in pharmacodynamic and pharmacokinetic pathways underlying drug-induced arrhythmia and sudden unexplained deaths<\/strong>. <em>Forensic Sci Int Genet.<\/em> 2019; 42:203-212. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.fsigen.2019.07.010\">doi: 10.1016\/j.fsigen.2019.07.010<\/a><\/strong><\/span><\/li>\n<li>Blanco-Verea A, Ramos-Luis E, Garc\u00eda-Seara J, Carracedo \u00c1, Gonz\u00e1lez-Juanatey JR, Brion M. <strong>A Novel Calsequestrin 2 Deletion Causing Catecholaminergic Polymorphic Ventricular Tachycardia and Sudden Cardiac Death.<\/strong> <em>Rev Esp Cardiol (Engl Ed)<\/em>. 2019;72(8):681-683. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.rec.2018.07.005\">doi: 10.1016\/j.rec.2018.07.005<\/a><\/strong><\/span><\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Group web&#8221; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]https:\/\/[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Lead researcher<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-11048\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"18796\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/en\/team\/maria-jose-brion-martinez\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"18796\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/brion-martinez-cardiochus-315x320.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/brion-martinez-cardiochus-315x320.jpg\" alt=\"Mar\u00eda Jos\u00e9 Bri\u00f3n Mart\u00ednez\" width=\"315\" height=\"320\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tMar\u00eda Jos\u00e9 Bri\u00f3n Mart\u00ednez\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>maria.brion@usc.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-phone\">\n<i class=\"fa fa-phone\"><\/i>\t<a href=\"#0\"  class=\"\" >\n\t\t<span>(+34) 981 955 310<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-website\">\n<i class=\"fa fa-globe\"><\/i>\t<a href=\"http:\/\/orcid.org\/0000-0001-7463-2148\"  class=\"\" target=\"_blank\">\n\t\t<span>http:\/\/orcid.org\/0000-0001-7463-2148<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/en\/team\/maria-jose-brion-martinez\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: CARDIOVASCULARObjectives The main objective is the knowledge of the genetic bases of cardiovascular disease in general, focusing mainly on:- Genetics of familial heart disease- Genetics of chemotherapy-induced cardiotoxicity- Genetics [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":10311,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[509],"project_tag":[],"class_list":["post-18972","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-cardiovascular-en"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/18972","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/comments?post=18972"}],"version-history":[{"count":20,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/18972\/revisions"}],"predecessor-version":[{"id":35724,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/18972\/revisions\/35724"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/media\/10311"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/media?parent=18972"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project_category?post=18972"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project_tag?post=18972"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}