{"id":18996,"date":"2022-01-17T10:37:40","date_gmt":"2022-01-17T09:37:40","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e049-control-de-regulacion-genica-en-enfermedades-generegulon\/"},"modified":"2026-03-09T12:03:06","modified_gmt":"2026-03-09T11:03:06","slug":"e049-control-de-regulacion-genica-en-enfermedades-generegulon","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/e049-control-de-regulacion-genica-en-enfermedades-generegulon\/","title":{"rendered":"C046 \u2013 Gene Regulatory Control in Disease (GeneRegulon)"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.16″ _module_preset=”default” width=”100%” custom_padding=”0px||||false|false” locked=”on” collapsed=”on” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

\u00c1REA: NEUROCIENCIAS<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ _module_preset=”default” width=”100%” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.idisantiago.es\/wp-content\/uploads\/2021\/11\/grupo_investigacion.jpg” title_text=”Corporate portrait of office workers and employees” disabled_on=”on|on|on” admin_label=”Imagen” _builder_version=”4.16″ _module_preset=”default” disabled=”on” global_colors_info=”{}”][\/et_pb_image][et_pb_toggle title=”Objeticves and lines of research” admin_label=”Objetivos y l\u00edneas de investigaci\u00f3n” _builder_version=”4.19.4″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”]<\/p>\n

Objectives<\/h3>\n

The regulation of gene expression is key to understanding cell behavior. It is precisely controlled to ensure that specific genes are expressed at the appropriate times and levels in response to various genetic and environmental signals, which determines the biological processes that operate in the cell. Therefore, its alteration often leads to disease.
Using both experimental and computational approaches, our laboratory aims to deconstruct the mechanistic basis for the control of gene expression in pathological and developmental contexts at the level of individual genes to complete genomes.<\/p>\n

Lines of research<\/h3>\n
\n

We are interested in multiple aspects of gene expression control, including transcriptional, translational and post-translational control mechanisms, with a particular focus on nervous disorders, liver diseases and cancer.<\/p>\n

1. Nerve Disorders: Work in the laboratory addresses a number of intertwined problems in Schwann cell biology, ranging from axonal myelination to Schwann cell response to pathological conditions, including nerve injury, disorders genetics, immune cell attack and microbial infections.<\/p>\n

2. Cancer: We are focused on identifying therapeutic targets for neurofibromatosis type 1 and malignant peripheral nerve sheath tumors (MPNST).<\/p>\n

3. Liver disease: We are investigating the molecular mechanisms underlying liver cellular responses to chronic liver diseases of various etiologies, including non-alcoholic fatty liver disease (NAFLD), drugs and cholestatic disease, as well as the liver regenerative response after liver resection.<\/p>\n<\/div>\n

[\/et_pb_toggle][et_pb_toggle title=”Research team” admin_label=”Equipo investigador” _builder_version=”4.21.0″ _module_preset=”default” body_font=”|300|||||||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n\n\n\n
Leader<\/strong>
Woodhoo, Ashwin<\/p>\n

 <\/p>\n

Members<\/strong>
Aguirre Azor\u00edn, Pablo
Anguita Gal\u00e1n, Loida
Aparicio Rey, Adri\u00e1n
Ayuso Garc\u00eda, Paula
Ca\u00f1as Mart\u00edn, Jorge
Capelo Diz, Alba
Cobas Carre\u00f1o, Mar\u00eda
De Lucas Herrero, Pablo Jos\u00e9
Esquinas Rom\u00e1n, Eva Mar\u00eda
Ferrer Pin\u00f3s, Aroa<\/p>\n<\/td>\n

Garc\u00eda L\u00f3pez, Carmen
Larraona S\u00e1nchez, Elena
Pe\u00f1a Romero, Raquel
Perdikari, Sof\u00eda
P\u00e9rez Sanz, Marina Leonor
Posado Fern\u00e1ndez, Adri\u00e1n
Riobello Su\u00e1rez, Cristina
Rodr\u00edguez Ponte, Carlos
S\u00e1nchez Rueda, Alejandro
Tinahones Ruano, Alberto Jes\u00fas
Varela Rey, Marta
Wang, Yuqing<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/et_pb_toggle][et_pb_toggle title=”Projects” admin_label=”Proyectos (cambiar s\u00f3 codigo IDIS)” _builder_version=”4.19.4″ _module_preset=”default” body_font=”|300|||||||” locked=”on” global_colors_info=”{}”]<\/p>\nIdentification of new predictors of hepatic fibrosis<\/strong>
Entidad financiadora: Fundaci\u00f3n BBVA
Investigador\/a principal: <\/a> Marta Varela Rey
<\/p>\n

\n

[\/et_pb_toggle][et_pb_toggle title=”Publications” admin_label=”Publicaciones” _builder_version=”4.19.4″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”]<\/p>\n