[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ _module_preset=”default” width=”100%” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/10\/Tomas-Sobrino.jpg” title_text=”Tomas Sobrino” disabled_on=”on|on|on” _builder_version=”4.18.0″ _module_preset=”default” disabled=”on” global_colors_info=”{}”][\/et_pb_image][et_pb_toggle title=”Objectives and lines of research” disabled_on=”off|off|off” admin_label=”Objetivos y l\u00edneas de investigaci\u00f3n” _builder_version=”4.19.4″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”]<\/p>\n
Lines of research<\/h3>\n
The Neuroaging Group presents 3 main lines of research:<\/p>\n
1. Early Diagnosis and Therapy of Alzheimer’s Disease and other dementias (main line)<\/strong> 2. Biomarkers and regenerative therapy in neurological diseases associated with aging (secondary line)<\/strong> 3. Neurobiology underlying neurological diseases associated with aging<\/strong> [\/et_pb_toggle][et_pb_toggle title=”Research team” admin_label=”Equipo investigador” _builder_version=”4.21.0″ _module_preset=”default” body_font=”|300|||||||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Currently, Alzheimer’s disease is the leading cause of dementia and disability in people older than 64 years. In Europe there are some 7.5 million people affected by some type of dementia, and considering the increase in the aging of the population and the survival rate, it is estimated that by 2050 these values \u200b\u200bwill grow exponentially, making the impact of dementia more pronounced. disease in healthcare systems. Currently there is no effective treatment to reverse the course of Alzheimer’s disease, and the detection of the disease in its early stages is still a great challenge for modern medicine. Today, the diagnosis of this disease takes place when a large neuronal loss has already occurred (recent estimates indicate a value close to 70%). Because of this, a lot of effort is being devoted to the development of new, more effective tools. The proposed scientific activity constitutes a response to the need for an early diagnosis. Being able to diagnose the disease earlier and therefore delaying its onset is estimated to represent a saving of 50% in the total costs associated with this disease.
Specifically, this line of research aims to develop nanoplatforms, neuroimaging, and in vitro tests for the diagnosis and therapy of Alzheimer’s Disease (AD) and other dementias.<\/p>\n
In addition to dementia, stroke is another neurological pathology associated with aging and is the leading cause of morbidity and mortality in Europe. Currently there is no effective pharmacological treatment for intracerebral hemorrhage and pharmacological or mechanical reperfusion emerges as an effective therapy for acute ischemic stroke, but such treatment reaches less than 10% of patients. Due to this, it is necessary to identify new biomarkers to improve the management of these patients, as well as to develop new therapies. One section of the proposed scientific activity aims to identify biomarkers in ischemic and hemorrhagic stroke, as well as the development of cell therapy and regenerative medicine (through in vivo reprogramming) as therapeutic options for stroke and dementia.<\/p>\n
Finally, every disease is associated with molecular mechanisms. It is vitally important to identify these mechanisms that may constitute new therapeutic targets in prevalent neurological diseases associated with aging such as dementia and cerebrovascular disease. The proposed scientific activity presents a line of secondary research focused on the identification of molecular mechanisms, in patients as well as preclinical models, underlying these pathologies and their subsequent testing as biomarkers or therapeutic targets.<\/p>\n
![\"Tom\u00e1s](\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/10\/Tomas-Sobrino-320x320.jpg\")
\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t