[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ _module_preset=”default” width=”100%” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/05\/Foto-grupo-abril-2022-scaled.jpg” title_text=”Foto grupo abril 2022″ disabled_on=”off|off|off” admin_label=”Imagen” _builder_version=”4.17.0″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_toggle title=”Objectives and lines of research” admin_label=”Objetivos y l\u00edneas de investigaci\u00f3n” _builder_version=”4.21.0″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”]<\/p>\n
Objectives<\/h3>\n
For years our work has focused on studying the cellular and molecular mechanisms responsible for neurodegeneration in Parkinson’s disease, identifying key points for therapeutic intervention. We aim to transform this knowledge into effective neuroprotective strategies that preserve the function of dopaminergic neurons and facilitate their translation to clinical practice. <\/p>\n
We work to validate new therapeutic targets, such as the cerebral renin-angiotensin system and pathological alpha-synuclein, and to promote high-precision cell models, based on stem cells, that accelerate the development of drugs and neuronal replacement strategies.<\/p>\n
We also seek to prevent treatment-related complications (such as dyskinesias) and develop early biomarkers that allow intervention in the initial stages of the disease, when it is still possible to modify its evolution.<\/p>\n
Lines of research<\/h3>\n\n- Deciphering the molecular mechanisms of neurodegeneration in Parkinson’s disease<\/li>\n
- Development of neuroprotective strategies with translational potential<\/li>\n
- Study of the cerebral renin-angiotensin system as a therapeutic target<\/li>\n
- Characterization of the pathogenicity of alpha-synuclein<\/li>\n
- Development of precision cell models based on stem cells<\/li>\n
- Identification of mechanisms involved in treatment-induced dyskinesias<\/li>\n
- Identification of early biomarkers of neurodegeneration<\/li>\n<\/ul>\n
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[\/et_pb_toggle][et_pb_toggle title=”Research team” admin_label=”Equipo investigador” _builder_version=”4.21.0″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”]<\/p>\n
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[\/et_pb_toggle][et_pb_toggle title=”Research team” admin_label=”Equipo investigador” _builder_version=”4.21.0″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”]<\/p>\n
![\"Jos\u00e9](\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/JoseLuislabandeira_CR-320x320.jpg\")
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