{"id":19038,"date":"2022-01-14T12:04:54","date_gmt":"2022-01-14T11:04:54","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/c009-investigacion-traslacional-en-enfermedades-del-aparato-digestivo\/"},"modified":"2026-01-12T13:22:39","modified_gmt":"2026-01-12T12:22:39","slug":"c009-investigacion-traslacional-en-enfermedades-del-aparato-digestivo","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/c009-investigacion-traslacional-en-enfermedades-del-aparato-digestivo\/","title":{"rendered":"C009 \u2013 Translational Research in Digestive System Diseases"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u00c1REA:\u00a0<a href=\"https:\/\/www.idisantiago.es\/areas-de-investigacion\/a002-genetica-y-biologia-de-sistemas\/\">GEN\u00c9TICA Y BIOLOG\u00cdA DE SISTEMAS<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2021\/11\/grupo_investigacion.jpg&#8221; title_text=&#8221;Corporate portrait of office workers and employees&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Objectives and lines of research&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Objetivos y l\u00edneas de investigaci\u00f3n&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Objectives<\/h3>\n<p>Our research group develops lines of clinical research and translational research in diseases of the digestive system, specifically in the areas listed below.<\/p>\n<ul>\n<li><strong>Etiopathogenetic and pathophysiological bases of diseases of the exocrine pancreas<\/strong> <strong>and their diagnostic and therapeutic implications<\/strong>. Effect of toxic habits (alcohol and tobacco consumption) on the risk of chronic pancreatitis, age and clinical presentation of the disease, its clinical course and prognosis, and the risk of developing pancreatic cancer. Genetic factors predisposing to the development of chronic pancreatitis and pancreatic cancer (mutations of the cationic trypsinogen genes, SPINK1 and CFTR). Study of the process of pancreatic fibrogenesis in chronic pancreatitis and its quantification by means of serological and elastographic techniques. Molecular and biological study of pancreatic cancer and its clinical implications on the characteristics of the tumor (degree of cell differentiation and locoregional extension), patient survival, and its potential application as therapeutic targets. Potential effect of cytotoxic bacteria isolated from pancreatic tumors on the carcinogenesis process in pancreatic cancer.<\/li>\n<li><strong>Epidemiological, etiopathogenic and therapeutic bases of inflammatory bowel disease (Crohn&#8217;s disease and ulcerative colitis)<\/strong>. Epidemiology of inflammatory bowel disease and its relationship with dietary, toxic and lifestyle habits. Role of infection by psychotrophic bacteria in the etiopathogenesis of Crohn&#8217;s disease. Efficacy of new immunomodulatory drugs in the treatment of patients with steroid-dependent and steroid-resistant inflammatory bowel disease.<\/li>\n<li><strong>Impact of hepatocellular carcinoma and its local percutaneous treatment on the survival of patients on waiting lists for liver transplantation<\/strong>. Antitumor efficacy and safety profile of percutaneous ethanol injection as neoadjuvant treatment for hepatocellular carcinoma on the liver transplant waiting list. Antitumor efficacy of percutaneous radiofrequency as neoadjuvant treatment of hepatocellular carcinoma and liver metastases from tumors in other locations.<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Research team&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Leader<\/strong><br \/>Dom\u00ednguez Mu\u00f1oz, Juan Enrique<\/p>\n<p><strong>Coleader\u00a0<\/strong><br \/>Pazos Randulfe, Yolanda<\/p>\n<p>&nbsp;<\/p>\n<table style=\"width: 100%; border-collapse: collapse; border-style: hidden;\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\"><strong>Members<\/strong><br \/>Barreiro de Acosta, Manuel<br \/>\u00c1lvarez Castro, Ana Mar\u00eda<br \/>Barreiro de Acosta, Manuel<br \/>Bast\u00f3n Rey, Iria<br \/>Calvi\u00f1o Su\u00e1rez, Cristina<br \/>D\u00edaz Arg\u00fceso, Laura<br \/>Dom\u00ednguez Novoa, Y\u00e9ssica<br \/>Fern\u00e1ndez de Castroagud\u00edn, Javier<br \/>Fern\u00e1ndez P\u00e9rez, Jos\u00e9 Aquilino<br \/>Ferreiro Iglesias, Roc\u00edo<br \/>Galego Fern\u00e1ndez, Marco<br \/>Iglesias Garc\u00eda, Julio<br \/>Jim\u00e9nez S\u00e1nchez, Javier<br \/>Lari\u00f1o Noia, Jos\u00e9<br \/>Leal L\u00f3pez, Sa\u00fal<br \/>L\u00f3pez D\u00edaz, Javier<br \/>Loureiro Veira, Marti\u00f1o<br \/>Mac\u00edas Garc\u00eda, Fernando<\/td>\n<td style=\"width: 50%;\">Mart\u00edn Carreras-Presas, Francisco Luis<br \/>Mart\u00ednez-Seara V\u00e1zquez, Xurxo Francisco<br \/>Meijide Fern\u00e1ndez, Ignacio<br \/>Mejuto Fern\u00e1ndez, Rafael<br \/>M\u00edguez S\u00e1nchez, Patricia<br \/>Molina P\u00e9rez, Esther<br \/>Monteserin Ron, Luzdivina<br \/>Montoto Meijide, Rodrigo<br \/>Nieto Garc\u00eda, Laura<br \/>Otero Fraga, Mar\u00eda Jos\u00e9<br \/>Otero Iglesias, M\u00f3nica<br \/>Otero Iglesias, Paula<br \/>Porto Silva, Mar\u00eda del Sol<br \/>Quiroga Casti\u00f1eira, Adriano<br \/>Rama Fern\u00e1ndez, Alberto<br \/>Vallejo Senra, Nicolau<br \/>Varo P\u00e9rez, Evaristo<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Projects&#8221; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; disabled=&#8221;on&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publications&#8221; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Publicaci\u00f3n 1<\/li>\n<li>Publicaci\u00f3n 2<\/li>\n<li>Etc.<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Group website&#8221; 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border-right-width: 0; } }div, h2, h4,.sptp-member-name-title { font-family: 'Roboto'; } #sptp-7994 .sptp-member-name .sptp-member-name-title{ color:#8A7A0F; } #sptp-7994 .sptp-member-profession .sptp-jop-title{ color:#9EA1B3; font-weight: 200; }<\/style><div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" > <div id=\"sptp-10549\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" > <div class=\"sp-team-pro-page-loading-image\"><\/div> <div class=\"sptp-grid\"> <div class=\"sptp-row \"> <div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\" data-member=\"18169\"> <div class=\"sptp-member border-bg-around-member sptp-bottom-content sptp-square\"> <a class=\"sptp-member-avatar \" href=https:\/\/www.idisantiago.es\/en\/team\/juan-enrique-dominguez-munoz\/ target=_blank > <div class=\"sptp-member-avatar-img-area\" data-id=\"18169\"> <div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image \"> <div class=\"sptp-overflow-h\"> <div class=\"sptp-icon text-center\"> <i class=\"fa fa-plus\"><\/i> <\/div> <img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img \" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/JEnriqueDominguez_CR-320x320.jpg\" alt=\"Juan Enrique Dom\u00ednguez Mu\u00f1oz\" width=\"320\" height=\"320\"> <\/div> <\/div> <\/div> <\/a> <div class=\"sptp-member-name \"> <h2 class=\"sptp-name\">Juan Enrique Dom\u00ednguez Mu\u00f1oz<\/h2><\/div> <div class=\"sptp-read-more-button\"> <a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/en\/team\/juan-enrique-dominguez-munoz\/\" target=\"_blank\" > + INFO <\/a> <\/div> <\/div> <\/div> <\/div> <\/div> <\/div> <\/div> [\/et_pb_text][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; 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.sptp-col-lg-3.sptp-member:nth-child(6n-2) .sptp-arrow, .sptp-mosaic .sptp-col-lg-4.sptp-member:nth-child(8n) .sptp-arrow, .sptp-mosaic .sptp-col-lg-4.sptp-member:nth-child(8n-1) .sptp-arrow, .sptp-mosaic .sptp-col-lg-4.sptp-member:nth-child(8n-2) .sptp-arrow, .sptp-mosaic .sptp-col-lg-4.sptp-member:nth-child(8n-3) .sptp-arrow { left: auto; right: -20px; border-left-width: 20px; border-right-width: 0; } }div, h2, h4,.sptp-member-name-title { font-family: 'Roboto'; } #sptp-7994 .sptp-member-name .sptp-member-name-title{ color:#8A7A0F; } #sptp-7994 .sptp-member-profession .sptp-jop-title{ color:#9EA1B3; font-weight: 200; }<\/style><div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" > <div id=\"sptp-44064\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" > <div class=\"sp-team-pro-page-loading-image\"><\/div> <div class=\"sptp-grid\"> <div class=\"sptp-row \"> <div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\" data-member=\"47776\"> <div class=\"sptp-member border-bg-around-member sptp-bottom-content sptp-square\"> <a class=\"sptp-member-avatar \" href=https:\/\/www.idisantiago.es\/en\/team\/yolanda-pazos-randulfe\/ target=_blank > <div class=\"sptp-member-avatar-img-area\" data-id=\"47776\"> <div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image \"> <div class=\"sptp-overflow-h\"> <div class=\"sptp-icon text-center\"> <i class=\"fa fa-plus\"><\/i> <\/div> <img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img \" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2026\/06\/Foto-Yolanda-Pazos-320x320.jpg\" alt=\"Yolanda Pazos Randulfe\" width=\"320\" height=\"320\"> <\/div> <\/div> <\/div> <\/a> <div class=\"sptp-member-name \"> <h2 class=\"sptp-name\">Yolanda Pazos Randulfe<\/h2><\/div> <div class=\"sptp-member-email\"> <i class=\"fa fa-envelope\"><\/i> <a href=\"#0\" class=\"\"> <span>yolanda.pazos.randulfe@sergas.es<\/span> <\/a> <\/div> <div class=\"sptp-member-phone\"> <i class=\"fa fa-phone\"><\/i> <a href=\"#0\" class=\"\" > <span>+34 981 95 50 75<\/span> <\/a> <\/div> <div class=\"sptp-read-more-button\"> <a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/en\/team\/yolanda-pazos-randulfe\/\" target=\"_blank\" > + INFO <\/a> <\/div> <\/div> <\/div> <\/div> <\/div> <\/div> <\/div> \n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA:\u00a0GEN\u00c9TICA Y BIOLOG\u00cdA DE SISTEMASObjectives Our research group develops lines of clinical research and translational research in diseases of the digestive system, specifically in the areas listed below. Etiopathogenetic and [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":13038,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[506],"project_tag":[],"class_list":["post-19038","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-genetica-y-biologia-de-sistemas-en"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/19038","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/comments?post=19038"}],"version-history":[{"count":0,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/19038\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/media\/13038"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/media?parent=19038"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project_category?post=19038"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project_tag?post=19038"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}