{"id":19046,"date":"2022-01-14T11:13:52","date_gmt":"2022-01-14T10:13:52","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e028-senescencia-celular-cancer-y-envejecimiento\/"},"modified":"2026-03-05T13:21:14","modified_gmt":"2026-03-05T12:21:14","slug":"e028-senescencia-celular-cancer-y-envejecimiento","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/e028-senescencia-celular-cancer-y-envejecimiento\/","title":{"rendered":"C045 – Cellular senescence, cancer and aging"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.16″ _module_preset=”default” width=”100%” custom_padding=”0px||||false|false” locked=”on” collapsed=”on” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]\u00c1REA: ONCOLOG\u00cdA<\/a>
\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ _module_preset=”default” width=”100%” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/01\/Grupo-E028-1.jpg” title_text=”E028″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_toggle title=”Objectives and lines of research” admin_label=”Objetivos y l\u00edneas de investigaci\u00f3n” _builder_version=”4.19.4″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”]<\/p>\n

Objectives<\/h3>\n

Our group investigates an essential process for human health and disease, cellular senescence. This program allows the cells to defend themselves against multiple attacks, ensuring that the damaged cells cannot continue dividing and promoting the secretion of multiple factors that activate the immune system and promote the remodeling and repair of the affected tissue. Its correct functioning allows tissue homeostasis to be maintained, but its increase and accumulation, for example, during aging, can result in a multitude of pathologies that we know as diseases associated with aging and, among them, cancer.
In addition, antitumor therapy often leaves tumor cells in a senescent state, which limits their effectiveness. We work to identify new antitumor treatments that allow us to eliminate these senescent tumor cells by specifically inducing their death, which will allow us to have more effective treatments.<\/p>\n

Lines of research<\/h3>\n