{"id":19048,"date":"2022-01-14T10:52:22","date_gmt":"2022-01-14T09:52:22","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e004-oncologia-molecular\/"},"modified":"2026-02-05T14:23:12","modified_gmt":"2026-02-05T13:23:12","slug":"e004-oncologia-molecular","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/e004-oncologia-molecular\/","title":{"rendered":"E004 – Molecular oncology"},"content":{"rendered":"

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AREA: ONCOLOGY<\/a><\/p>\n

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Objectives<\/h3>\n

The need to develop personalized treatments, in the case of tumor processes, not only drives a better understanding of the molecular events involved in the pathogenesis of cancer, but also the design of experimental models that allow studying the effect of the activation of certain oncogenes and \/ or the inactivation of certain tumor suppressor genes in response to antitumor therapy. The group combines both aspects, developing cancer models that allow studying the influence of certain mutations on pathogenesis and their response to therapy. Although the molecular basis of tumors is complex, the aberrant activation of certain intracellular signaling pathways, as well as the inactivation of pathways dependent on tumor suppressor genes, are common characteristics of most of them. Although great advances have been made in recent years in the knowledge of the pathophysiology of some types of tumors, more and better preclinical models are needed capable of recapitulating certain characteristics of the tumor, such as the invasive capacity, cellular heterogeneity or neoangiogenesis. In conclusion, the main objective of our group is, using these tools, to identify new targets that allow the development of new diagnostic and therapeutic approaches, which will contribute to the improvement of the management of these pathologies.<\/p>\n

Lines of research<\/h3>\n

The Molecular Oncology group combines the study of molecular events involved in human pathologies, the generation of experimental models and new tools that allow the development and validation of new diagnostic and therapeutic approaches.<\/p>\n

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Leader<\/strong>
Costoya Puente, Jos\u00e9 Antonio<\/p>\n

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Members<\/strong>
Arce V\u00e1zquez, Victor
Ben Batalla, Isabel
Gonz\u00e1lez L\u00f3pez del Castillo, Catarina
Gonz\u00e1lez Rendo, Lara
Porres Vent\u00edn, Laura
Zumalave Rivas, Jos\u00e9 Antonio<\/p>\n<\/td>\n

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