{"id":19057,"date":"2022-01-13T15:38:18","date_gmt":"2022-01-13T14:38:18","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/c017-metodologia-de-la-investigacion\/"},"modified":"2026-01-12T13:34:21","modified_gmt":"2026-01-12T12:34:21","slug":"c017-metodologia-de-la-investigacion","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/c017-metodologia-de-la-investigacion\/","title":{"rendered":"C017 &#8211; Research methodology"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u00c1REA: <a href=\"https:\/\/www.idisantiago.es\/en\/research-areas-2\/a005-plataformas-y-metodologia\/\">PLATFORMS AND METHODOLOGY<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/resmet_logo_1.png&#8221; title_text=&#8221;resmet_logo_1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Objectives and lines of research&#8221; admin_label=&#8221;Objetivos y l\u00edneas de investigaci\u00f3n&#8221; _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Objectives<\/h3>\n<p>Interdisciplinary research group of the Institute that addresses the challenges caused by the increase in chronic diseases by applying new techniques to reduce the risk of disease.<\/p>\n<p>The main objective of the group is to generate valid knowledge for the whole of the National Health System. The group&#8217;s mission is to stimulate and support the development and application of knowledge to improve the health of citizens by integrating three areas of research: diagnostic tests, clinical studies and research methods.<\/p>\n<h3>Lines of research<\/h3>\n<p>1. Carrying out observational and experimental studies that address chronic-prevalent diseases both from a population context and from patient care, and whose anchor point is Primary Health Care.<br \/>2. Development and implementation of new diagnostic tools related to inflammation and glycation parameters in chronic-prevalent diseases (alcoholism, obesity, diabetes, liver disease, cardiovascular disease, allergy, cancer, among others).<br \/>3. Development of innovative procedures and methodologies that promote the management, analysis and presentation of research results in accordance with the new times.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Research team&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<table style=\"width: 100%; border-collapse: collapse; border-style: hidden;\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\">\n<p><strong>Leader<\/strong><br \/>Gude Sampedro, Francisco\u00a0<\/p>\n<p><strong>Colead\u00a0<\/strong><br \/>Alonso Sampedro, Manuela<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Members<\/strong><br \/>Barrera L\u00f3pez, Luc\u00eda<br \/>Ben\u00edtez Est\u00e9vez, Alfonso Javier<br \/>Calvo Malvar, Mar\u00eda del Mar<br \/>Carballo Fern\u00e1ndez, Iago<br \/>Estany Gestal, Ana<br \/>Fern\u00e1ndez Merino, Mar\u00eda del Carmen<br \/>Garc\u00eda-Ciudad Young, Vanesa<br \/>Gonz\u00e1lez Quintela, Arturo<br \/>L\u00f3pez Gonz\u00e1lez, Sof\u00eda<br \/>Marco Rodr\u00edguez, Alejandra<br \/>Mart\u00edn Ventoso, Carlota<br \/>Molares Vila, Alberto<br \/>Otero Ant\u00f3n, Esteban<br \/>Pazos Couselo, Marcos<br \/>P\u00e9rez Su\u00e1rez, Luis Fernando<br \/>Pose Arufe, Alberto<br \/>S\u00e1nchez Castro, Juan Jos\u00e9<br \/>Tom\u00e9 Mart\u00ednez de Rituerto, Santiago<br \/>V\u00e1zquez Agra, N\u00e9stor<br \/>Vidal Pan, Carmen<br \/>Zamarr\u00f3n Sanz, Carlos<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/td>\n<td style=\"width: 50%;\">\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Projects&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publications&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>\u00a0Gude-Sampedro F, Fern\u00e1ndez-Merino C, Ferreiro L, Lado-Baleato \u00d3, Espasand\u00edn-Dom\u00ednguez J, Hervada X, Cadarso CM, Vald\u00e9s L. <strong>Development and validation of a prognostic model based on comorbidities to predict Covid-19 severity. A population-based study<\/strong>. <em>Int J Epidemiol<\/em>. 2021 Mar 3;50(1):64-74. \u00a0<span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1093\/ije\/dyaa209\">doi: 10.1093\/ije\/dyaa209<\/a><\/strong><\/span>.<\/li>\n<li>Alende-Castro V, Alonso-Sampedro M, Fern\u00e1ndez-Merino C, S\u00e1nchez-Castro J, Sope\u00f1a B, Gude F, Gonzalez-Quintela A. <strong>C-Reactive Protein versus Erythrocyte Sedimentation Rate: Implications Among Patients with No Known Inflammatory Conditions<\/strong>.\u00a0 <em>J Am Board Fam Med<\/em>. 2021 Sep-Oct;34(5):974-983. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.3122\/jabfm.2021.05.210072\">doi: 10.3122\/jabfm.2021.05.210072<\/a><\/strong><\/span>.<\/li>\n<li>Matabuena M, Petersen A, Vidal JC, Gude F. <strong>Glucodensities: A new representation of glucose profiles using distributional data analysis<\/strong>.\u00a0<em> Stat Methods<\/em> <em>Med Res.<\/em> 2021 Jun;30(6):1445-1464. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1177\/0962280221998064\">doi: 10.1177\/0962280221998064<\/a><\/strong><\/span>.<\/li>\n<li>Calvo-Malvar M, Ben\u00edtez-Est\u00e9vez AJ, S\u00e1nchez-Castro J, Leis R, Gude F. <strong>Effects of a Community-Based Behavioral Intervention with a Traditional Atlantic Diet on Cardiometabolic Risk Markers: A Cluster Randomized Controlled Trial (&#8220;The GALIAT Study&#8221;).<\/strong> <em>Nutrients<\/em>. 2021 Apr 7;13(4):1211. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.3390\/nu13041211\">doi: 10.3390\/nu13041211.<\/a><\/strong><\/span><\/li>\n<li>Dieguez-Alvarez M, Carballo I, Alonso-Sampedro M, Sope\u00f1a B, Gude F, Gonzalez-Quintela A.<strong> Serum immunoglobulin-A (IgA) concentrations in a general adult population: association with demographics and prevalence of selective IgA deficiency. <\/strong><em>Clin Chem Lab Med<\/em>. 2020 Mar 26;58(4):e109-e112.<span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1515\/cclm-2019-0957\"> doi: 10.1515\/cclm-2019-0957<\/a><\/strong><\/span><\/li>\n<li>Skaaby T, Kilpel\u00e4inen TO, Taylor AE, Mahendran Y, Wong A, Ahluwalia TS, Paternoster L, Trompet S, Stott DJ, Flexeder C, Zhou A, Brusselle G, Sajjad A, Lahousse L, Tiemeier H, Have CT, Thuesen BH, K\u00e5rhus LL, M\u00f8llehave LT, Leth-M\u00f8ller KB, Shabanzadeh DM, Gonzalez-Quintela A, Power C, Hypp\u00f6nen E, Kuh D, Hardy R, Meitinger T, Jukema JW, V\u00f6lker U, Nauck M, V\u00f6lzke H, Friedrich N, Bonten TN, Noordam R, Mook-Kanamori DO, Tolstrup JS, Taube C, Peters A, Grallert H, Strauch K, Schulz H, Grarup N, Hansen T, Pedersen O, Burgess S, Munaf\u00f2 MR, Linneberg A. <strong>Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis.<\/strong>\u00a0 <em>Addiction<\/em>. 2019 Feb;114(2):216-225. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1111\/add.14438\">doi: 10.1111\/add.14438<\/a><\/strong><\/span>.<\/li>\n<li>Vidal C, Rodr\u00edguez Del R\u00edo P, Gude F, Casale T, Cox L, Just J, Pfaar O, Demoly P, Calder\u00f3n MA. <strong>Comparison of international systemic adverse reactions due to allergen immunotherapy<\/strong>.<em> J Allergy Clin Immunol Pract.<\/em> 2019 Apr;7(4):1298-1305.e3. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.jaip.2018.12.006\">doi: 10.1016\/j.jaip.2018.12.006.<\/a><\/strong><\/span><\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Group website&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"6QtorkxjRV\"><p><a href=\"https:\/\/resmet.org\/\">Idis<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"\u00abIdis\u00bb \u2014 Resmet\" src=\"https:\/\/resmet.org\/embed\/#?secret=7nc6nSGLoK#?secret=6QtorkxjRV\" data-secret=\"6QtorkxjRV\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Lead researcher<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-10269\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"16727\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/en\/team\/francisco-gude-sampedro\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"16727\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2026\/01\/USC-Santiago-Francisco-Gude-2-320x320.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2026\/01\/USC-Santiago-Francisco-Gude-2-320x320.jpg\" alt=\"Francisco Gude Sampedro\" width=\"320\" height=\"320\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tFrancisco Gude Sampedro\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>francisco.gude.sampedro@sergas.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-phone\">\n<i class=\"fa fa-phone\"><\/i>\t<a href=\"#0\"  class=\"\" >\n\t\t<span>(+34) 981 950 033<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-website\">\n<i class=\"fa fa-globe\"><\/i>\t<a href=\"http:\/\/orcid.org\/0000-0002-9681-1662\"  class=\"\" target=\"_blank\">\n\t\t<span>http:\/\/orcid.org\/0000-0002-9681-1662<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/en\/team\/francisco-gude-sampedro\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h2>Colead researcher<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-44108\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"44107\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/team\/manuela-alonso-sampedro\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"44107\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2026\/01\/ManuelaAlonsoSampedro-scaled-e1768551374287-320x320.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2026\/01\/ManuelaAlonsoSampedro-scaled-e1768551374287-320x320.jpg\" alt=\"Manuela Alonso Sampedro\" width=\"320\" height=\"320\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tManuela Alonso Sampedro\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>Manuela.Alonso.Sampedro@sergas.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-phone\">\n<i class=\"fa fa-phone\"><\/i>\t<a href=\"#0\"  class=\"\" >\n\t\t<span>981 951 774<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-website\">\n<i class=\"fa fa-globe\"><\/i>\t<a href=\"http:\/\/orcid.org\/0000-0002-0916-4672\"  class=\"\" target=\"_blank\">\n\t\t<span>http:\/\/orcid.org\/0000-0002-0916-4672<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/team\/manuela-alonso-sampedro\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: PLATFORMS AND METHODOLOGYObjectives Interdisciplinary research group of the Institute that addresses the challenges caused by the increase in chronic diseases by applying new techniques to reduce the risk of 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