{"id":19058,"date":"2022-01-13T15:36:35","date_gmt":"2022-01-13T14:36:35","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/c026-biofarma\/"},"modified":"2026-03-06T13:10:57","modified_gmt":"2026-03-06T12:10:57","slug":"c026-biofarma","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/c026-biofarma\/","title":{"rendered":"C026 &#8211; BIOFARMA"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;on&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u00c1REA: <a href=\"https:\/\/www.idisantiago.es\/en\/research-areas-2\/a002-genetica-y-biologia-de-sistemas\/\">GEN\u00c9TICA Y BIOLOG\u00cdA DE SISTEMAS<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Grupo-C026-scaled.jpg&#8221; title_text=&#8221;Grupo C026&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Objectives and lines of research&#8221; admin_label=&#8221;Objetivos y l\u00edneas de investigaci\u00f3n&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Objectives<\/h3>\n<p>The BioFarma research group has a proven track record in applied research for early drug discovery in collaboration with the biotechnology and pharmaceutical industry. BioFarma is involved in the open innovation models that have been implemented in the pharmaceutical sector in recent years and have allowed a significant increase in public-private collaboration.<br \/>BioFarma is one of the High Capacity Screening Centers of the European Research Infrastructure Consortium ERIC EU-OPENSCREEN (European Infrastructure of Open Screening Platforms for Chemical Biology). It has a human group of more than 30 professionals that includes doctors in pharmacy, medicine, biology and chemistry, as well as pharmacists, chemists and biologists, laboratory technicians, etc. This human group has extensive experience in different aspects of assay development, assay miniaturization, design and execution of screening cascades, in vitro safety panels, ADME, etc. It is an international multidisciplinary team with experts in constant adaptation to new technologies, which allows great robustness in the results obtained.<\/p>\n<h3>Lines of research<\/h3>\n<ul>\n<li>G-Protein coupled receptors<\/li>\n<li>Pharmacology in translational research.<\/li>\n<li>Fine-tuning and miniaturization of techniques for High Throughtput Screening (HTS)<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Research team&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><span style=\"font-size: 14px;\"><strong>Leader<\/strong><br \/>Loza Garc\u00eda, Mar\u00eda Isabel<\/span><\/p>\n<p>&nbsp;<\/p>\n<div><strong><span style=\"font-size: 14px;\">Members<\/span><\/strong><\/div>\n<div>Abeig\u00f3n Moure, Juan<br \/>Acu\u00f1a Fari\u00f1a, Juan<br \/>Ardao Palacios, In\u00e9s<br \/>Arrabal Ayala, Mar\u00eda<br \/>Asensio L\u00f3pez, Mar\u00eda Magdalena<br \/>Baleir\u00f3n Rodr\u00edguez, Mart\u00edn<br \/>Blanco Babarro, Borja<br \/>Cadavid Torres, Mar\u00eda Isabel<br \/>Casariego Pedreira, Yaiza<br \/>Castro P\u00e9rez, Mar\u00eda de los \u00c1ngeles<br \/>Daudey, Geert<br \/>G\u00f3mez Carballo, Laura<br \/>Guerra Hiniestro, Rodrigo<br \/>Iglesias Fern\u00e1ndez, Mar\u00eda Isabel<br \/>Lest\u00f3n Novoa, \u00d3scar<br \/>L\u00f3pez Fern\u00e1ndez, Daniel<br \/>Mart\u00ednez Rodr\u00edguez, Ant\u00f3n Leandro<br \/>Moreira \u00c1lvarez, David<br \/>Pi\u00f1a M\u00e1rquez, Roc\u00edo<br \/>Ramos Caama\u00f1o, Jos\u00e9 Manuel<br \/>Rob\u00e9s Ysart, Diego<br \/>Santamar\u00eda Cadavid, Eduardo<br \/>Santamar\u00eda P\u00e9rez, Jos\u00e9 Manuel<br \/>Silva Vieira, Luc\u00eda<br \/>Solla Villaverde, Marta<br \/>Val Garc\u00eda, Cristina<br \/>Valarezo Riascos, Lesley Paola<br \/>Varela Liste, Mar\u00eda Jos\u00e9<br \/>Villar Rendo, Mar\u00eda<\/div>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Projects&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publications&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Mart\u00ednez AL, Brea J, Monroy X, Merlos M, Burgue\u00f1o J, Loza MI. <strong>A New Model of Sensorial Neuron-Like Cells for HTS of Novel Analgesics for Neuropatic Pain.<\/strong> <em>SLAS Discovery<\/em> 2019 Feb;24(2):158-168. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1177\/2472555218810323\">doi: 10.1177\/2472555218810323<\/a><\/strong>.<\/span><\/li>\n<li>Perez Mato M, Iglesias Rey R, Vieites Prado A, Dopico Lopez A, Argibay B, Fern\u00e7andez Susavila H, da Silva Candal A, Perez Diaz A, Correa Paz C, G\u00fcnther A, Avila G\u00f3mez P, Isabel Loza M, Baumann A, Castillo J, Sobrino T, Campos F. <strong>Blood glutamate EAAT2-cell grabbing therapy in cerebral ischemia.<\/strong> <em>EBioMedicine<\/em>, 2019 Jan; 39:118-131.<span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.ebiom.2018.11.024\"> doi: 10.1016\/j.ebiom.2018.11.024<\/a><\/strong><\/span><\/li>\n<li>Triana-Mart\u00ednez F, Picallos-Rabina P, Da Silva-\u00c1lvarez S, Pietrocola F, Llanos S, Rodilla V, Soprano E, Pedrosa P, Ferreir\u00f3s A, Barradas M, Hern\u00e1ndez-Gonz\u00e1lez F, Lalinde M, Prats N, Bernad\u00f3 C, Gonz\u00e1lez P, G\u00f3mez M, Ikonomopoulou MP, Fern\u00e1ndez-Marcos PJ, Garc\u00eda-Caballero T, Del Pino P, Arribas J, Vidal A, Gonz\u00e1lez-Barcia M, Serrano M, Loza MI, Dom\u00ednguez E, Collado M. <strong>Identification and characterization of Cardiac Glycosides as senolytic compounds.<\/strong> <em>Nat. Commun<\/em>. 2019 Oct 21;10(1): 4731.<\/li>\n<li>Mallo-Abreu A, Prieto-Diaz R, Jespers W, Azuaje J, Majellaro M, Velando C, Garc\u00eda-Mera X, Caama\u00f1o O, Brea JM, Loza MI, Guti\u00e9rrez-de-Ter\u00e1n H, Sotelo E. <strong>Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists.<\/strong><em> J Med Chem<\/em>. 2020 Jul 23;63(14):7721-7739.<a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.0c00564\"><span style=\"color: #808000;\"><strong> doi: 10.1021\/acs.jmedchem.0c00564<\/strong><\/span><\/a>. Epub 2020 Jul 7<\/li>\n<li>Kampen, Stefanie; Duy Vo, Duc; Zhang, Xiaoqun; Panel, Nicolas; Yang, Yunting; Jaiteh, Mariama; Matricon, Pierre; Svenningsson, Per; Brea, Jose; Loza, Maria Isabel; Kihlberg, Jan; Carlsson, Jens. <strong>Structure-Guided Design of G-Protein-Coupled Receptor Polypharmacology<\/strong>. <em>Angewandte Chemie-International Edition<\/em>, Jul 2021. <a href=\"https:\/\/doi.org\/10.1002\/anie.202101478\"><span style=\"color: #808000;\"><strong>doi: 10.1002\/anie.202101478.<\/strong><\/span><\/a><\/li>\n<li>Mart\u00ednez AL, Brea J, Rico S, de Los Frailes MT, Loza MI. <strong>Cognitive Deficit in Schizophrenia: From Etiology to Novel Treatments.<\/strong><em> Int J Mol Sci.<\/em> 2021 Sep 14;22(18):9905. <a href=\"https:\/\/doi.org\/10.3390\/ijms22189905\"><span style=\"color: #808000;\"><strong>doi: 10.3390\/ijms22189905<\/strong><\/span><\/a>.<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Group website&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><a href=\"https:\/\/www.usc.gal\/biofarma\/\">https:\/\/www.usc.gal\/biofarma\/<\/a><\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Lead researcher<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-10268\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"18239\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/en\/team\/mabel-loza-garcia\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"18239\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/MABEL-LOZA--320x320.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/MABEL-LOZA--320x320.jpg\" alt=\"Mabel Loza Garc\u00eda\" width=\"320\" height=\"320\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tMabel Loza Garc\u00eda\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>biofarma.group@usc.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-phone\">\n<i class=\"fa fa-phone\"><\/i>\t<a href=\"#0\"  class=\"\" >\n\t\t<span>(+34) 881 815 459<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-website\">\n<i class=\"fa fa-globe\"><\/i>\t<a href=\"http:\/\/orcid.org\/0000-0003-4730-0863\"  class=\"\" target=\"_blank\">\n\t\t<span>http:\/\/orcid.org\/0000-0003-4730-0863<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/en\/team\/mabel-loza-garcia\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: GEN\u00c9TICA Y BIOLOG\u00cdA DE SISTEMASObjectives The BioFarma research group has a proven track record in applied research for early drug discovery in collaboration with the biotechnology and pharmaceutical industry. [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":12112,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[506],"project_tag":[],"class_list":["post-19058","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-genetica-y-biologia-de-sistemas-en"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/19058","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/comments?post=19058"}],"version-history":[{"count":23,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/19058\/revisions"}],"predecessor-version":[{"id":45587,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/19058\/revisions\/45587"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/media\/12112"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/media?parent=19058"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project_category?post=19058"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project_tag?post=19058"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}