{"id":19059,"date":"2022-01-13T15:32:59","date_gmt":"2022-01-13T14:32:59","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e026-fisiopatologia-endocrina\/"},"modified":"2026-02-05T12:26:28","modified_gmt":"2026-02-05T11:26:28","slug":"e026-fisiopatologia-endocrina","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/e026-fisiopatologia-endocrina\/","title":{"rendered":"E026 – Endocrine Physiopathology"},"content":{"rendered":"

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\u00c1REA: ENDOCRINOLOG\u00cdA, NUTRICI\u00d3N Y METABOLISMO<\/a><\/p>\n

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Objectives<\/h3>\n

The Endocrine Pathophysiology (E26) research group, directed by PI Luisa Mar\u00eda Seoane Camino, focuses its studies on basic aspects of energy balance regulation through the interaction of peripheral mechanisms with the central nervous system. The general objective of the group is the search for mechanisms in peripheral tissues to adapt metabolism to the energy requirements demanded in each period of life.
As specific objectives, the group is specialised in:
\u2022 The search for the mechanisms that are altered in pathological situations such as obesity and other associated pathologies such as diabetes and hepatic steatosis.
\u2022 The identification of new therapeutic targets in obesity and associated pathologies (diabetes and hepatic steatosis). Carrying out preclinical studies in experimental animals, in vitro and ex vivo systems.
\u2022 The search for biomarkers of obesity and associated pathologies, especially in children.<\/p>\n

Lines of research<\/h3>\n

LINE 1. Study of the role of the brain-gastrointestinal tract-adipose tissue axis in the control of obesity and associated pathologies:
1a. Study of the role of the gastrointestinal tract in regulating the mechanisms involved in maintaining energy balance.
1b. Role of the Uroguanylin-GUCY2C System in obesity.
LINE 2. Involvement of D2 dopaminergic receptors in the regulation of body weight.
Regulation of the hypothalamic dopaminergic system by different peripheral signals involved in the control of energy homeostasis
LINE 3. Breastfeeding as a protective factor against the development of obesity in adulthood.
3a. Development of an animal model of prolonged lactation, metabolic characterization
3b. Study of the molecular mechanisms involved in the protective effect of breastfeeding against obesity.
3c. Role of intestinal microflora in the protective effect of breastfeeding against obesity.
3d. Study in children monitored in the Pediatric service of the University Hospital Complex of Santiago of the signals identified in animal models involved in the beneficial effect of breastfeeding.<\/p>\n

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Leader<\/strong>
Seoane Camino, Luisa Mar\u00eda<\/p>\n

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Members<\/strong>
Bascoy Otero, Miguel
Folgueira Cobos, Cintia
Garc\u00eda Palacios, Mar\u00eda
Gonz\u00e1lez Cea, Ana Cristina
Mu\u00f1oz Moreno, Diego
Pad\u00edn Villar, Albert
Qui\u00f1ones T\u00e9llez, Mar
Romero Rodr\u00edguez, Sergio
Ruiz Pi\u00f1\u00f3n, Manuel<\/p>\n<\/td>\n

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