{"id":22803,"date":"2022-04-18T09:04:05","date_gmt":"2022-04-18T07:04:05","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e037-reparacion-del-adn-e-integridad-del-genoma-2\/"},"modified":"2026-03-02T08:22:16","modified_gmt":"2026-03-02T07:22:16","slug":"e037-reparacion-del-adn-e-integridad-del-genoma-2","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/e037-reparacion-del-adn-e-integridad-del-genoma-2\/","title":{"rendered":"E037 &#8211; Reparaci\u00f3n del ADN e Integridad del Genoma"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;on&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u00c1REA: <a href=\"https:\/\/www.idisantiago.es\/en\/research-areas-2\/a001-oncologia\/\">ONCOLOG\u00cdA<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Grupo-E037-scaled.jpg&#8221; title_text=&#8221;Grupo E037&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Objectives and lines of research&#8221; admin_label=&#8221;Objetivos y l\u00edneas de investigaci\u00f3n&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Objetivos<\/h3>\n<p>Comprender los mecanismos de regulaci\u00f3n de enzimas de reparaci\u00f3n del ADN en eucariotas y su coordinaci\u00f3n con la progresi\u00f3n del ciclo celular.<\/p>\n<h3>L\u00edneas de investigaci\u00f3n<\/h3>\n<p>&#8211; Estudio del impacto de la activaci\u00f3n prematura de resolvasas de uniones de Holliday en la estabilidad gen\u00f3mica de eucariotas<br \/>&#8211; Estudio de los mecanismos de regulaci\u00f3n de nucleasas y helicasas de reparaci\u00f3n y su importancia en el procesado de estructuras secundarias del ADN.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Research team&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<table style=\"width: 100%; border-collapse: collapse; border-style: hidden;\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\"><strong>Leader<\/strong><br \/>Gonz\u00e1lez Blanco, Miguel<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Members<\/strong><br \/>Crugeiras R\u00edos, Mar\u00eda<br \/>Debasa Corral, Luc\u00eda<br \/>Miranda Abeij\u00f3n, Clara<\/p>\n<\/td>\n<td style=\"width: 50%;\">\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Projects&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<strong>Estudio bioqu\u00edmico del procesado de los intermediarios de la replicaci\u00f3n y la recombinaci\u00f3n del ADN<\/strong><br \/>C\u00f3digo del proyecto: BFU2016-78121-P<br \/>Entidad financiadora: Agencia Estatal de Investigaci\u00f3n<br \/>Duraci\u00f3n: 2017-2021<br \/>Investigador\/a principal: <a href=\"\"><\/a> <br \/><\/p>\n<p><strong>Regulaci\u00f3n de resolvasas en el procesado de estructuras secundarias del ADN<\/strong><br \/>C\u00f3digo del proyecto: PID2020-115472GB-I00<br \/>Entidad financiadora: Agencia Estatal de Investigaci\u00f3n<br \/>Duraci\u00f3n: 2021-2024<br \/>Investigador\/a principal: <a href=\"\"><\/a> <br \/><\/p>\n<p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publications&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Carreira R, Aguado FJ, Hurtado-Nieves V, Blanco MG. <strong>Canonical and novel non-canonical activities of the Holliday junction resolvase Yen1.<\/strong> <em>Nucleic Acids Res<\/em>. 2022 Jan 11;50(1):259-280. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34928393\/\"><span style=\"color: #808000;\"><strong>doi: 10.1093\/nar\/gkab1225<\/strong><\/span><\/a>.<\/li>\n<li>\u00c1lvarez EG, Demeulemeester J, Otero P, Jolly C, Garc\u00eda-Souto D, Peque\u00f1o-Valtierra A, Zamora J, Tojo M, Temes J, Baez-Ortega A, Rodriguez-Martin B, Oitaben A, Bruzos AL, Mart\u00ednez-Fern\u00e1ndez M, Haase K, Zumalave S, Abal R, Rodr\u00edguez-Castro J, RodriguezCasanova A, Diaz-Lagares A, Li Y, Raine KM, Butler AP, Otero I, Ono A, Aikata H, Chayama K, Ueno M, Hayami S, Yamaue H, Maejima K, Blanco MG, Forns X, Rivas C, Ruiz-Ba\u00f1obre J, P\u00e9rez-Del-Pulgar S, Torres-Ruiz R, Rodriguez-Perales S, Garaigorta U, Campbell PJ, Nakagawa H, Van Loo P, Tubio JMC. <strong>Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture<\/strong>. <em>Nat Commun<\/em>. 2021 Nov 25;12(1):6910. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34824211\/\"><span style=\"color: #808000;\"><strong>doi: 10.1038\/s41467-021-26805-8<\/strong><\/span><\/a>. PMID:34824211.<\/li>\n<li>Carreira R, Aguado FJ, Lama-Diaz T, Blanco MG. <strong>Holliday Junction Resolution<\/strong>. <em>Methods Mol Biol<\/em>. 2021;2153:169-185. <span style=\"color: #808000;\"><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32840779\/\">doi: 10.1007\/978-1-0716-0644-5_12<\/a>.<\/strong><\/span>. PMID: 32840779<\/li>\n<li>Guallar D, Fuentes-Iglesias A, Souto Y, Ameneiro C, FreireAgulleiro O, Pardavila JA, Escudero A, Garcia-Outeiral V, Moreira T,Saenz C, Xiong H, Liu D, Xiao S, Hou Y, Wu K, Torrecilla D, Hartner JC, Blanco MG, Lee LJ, L\u00f3pez M, Walkley CR, Wang J, Fidalgo M. <strong>ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress<\/strong>. <em>Cell Stem Cell<\/em>. 2020 Aug 6;27(2):300-314.e11. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32396862\/\"><span style=\"color: #808000;\"><strong>doi: 10.1016\/j.stem.2020.04.016<\/strong><\/span><\/a>. PMID: 32396862<\/li>\n<li>Morafraile EC, Bugallo A, Carreira R, Fern\u00e1ndez M, Mart\u00ednCastellanos C, Blanco MG, Segurado M. <strong>Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins<\/strong>. <em>Nucleic Acids Res<\/em>. 2020 Apr 6;48(6):3053-3070. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32020204\/\"><span style=\"color: #808000;\"><strong>doi: 10.1093\/nar\/gkaa054.<\/strong><\/span><\/a> PMID: 32020204<\/li>\n<li>Rodriguez-Martin B, Alvarez EG, Baez-Ortega A, Zamora J, Supek F, Demeulemeester J, Santamarina M, Ju YS, Temes J, Garcia-Souto D, Detering H, Li Y, Rodriguez-Castro J, Dueso-Barroso A, Bruzos AL,<br \/>Dentro SC, Blanco MG, Contino G, Ardeljan D, Tojo M, Roberts ND, Zumalave S, Edwards PAW, Weischenfeldt J, Puiggr\u00f2s M, Chong Z, Chen K, Lee EA, Wala JA, Raine K, Butler A, Waszak SM, Navarro<br \/>FCP, Schumacher SE, Monlong J, Maura F, Bolli N, Bourque G, Gerstein M, Park PJ, Wedge DC, Beroukhim R, Torrents D, Korbel JO, Martincorena I, Fitzgerald RC, Van Loo P, Kazazian HH, Burns KH,<br \/>Campbell PJ, Tubio JMC. <strong>Pan-cancer analysis of whole genomes identies driver rearrangements promoted by LINE-1 retrotransposition<\/strong>. <em>Nat Genet<\/em>. 2020 Mar;52(3):306-319. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32024998\/\"><span style=\"color: #808000;\"><strong>doi: 10.1038\/s41588-019-0562-0<\/strong><\/span>.<\/a> Epub 2020 Feb 5. PubMed PMID: 32024998<\/li>\n<li>Arter M, Hurtado-Nieves V, Oke A, Zhuge T, Wettstein R, Fung JC, Blanco MG, Matos J. <strong>Regulated Crossing-Over Requires Inactivation of Yen1\/GEN1 Resolvase during Meiotic Prophase I<\/strong>. <em>Dev Cell<\/em>. 2018 Jun 18;45(6):785-800.e6. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29920281\/\"><span style=\"color: #808000;\"><strong>doi: 10.1016\/j.devcel.2018.05.020<\/strong><\/span>.<\/a> PubMed PMID: 29920281<\/li>\n<li>\u00a0<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Group web&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><a href=\"https:\/\/www.usc.es\/cimus\/es\/investigacion\/grupos-de-investigacion\/dna-repair-and-genome-integrity\">https:\/\/www.usc.es\/cimus\/es\/investigacion\/grupos-de-investigacion\/dna-repair-and-genome-integrity<\/a><\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Investigador l\u00edder<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-10513\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"18858\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/en\/team\/miguel-gonzalez-blanco\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"18858\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Miguel-Gonzalez-Blanco-320x320.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Miguel-Gonzalez-Blanco-320x320.jpg\" alt=\"Miguel Gonz\u00e1lez Blanco\" width=\"320\" height=\"320\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tMiguel Gonz\u00e1lez Blanco\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>miguel.gonzalez.blanco@usc.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-phone\">\n<i class=\"fa fa-phone\"><\/i>\t<a href=\"#0\"  class=\"\" >\n\t\t<span>(+34) 881 815 405<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-website\">\n<i class=\"fa fa-globe\"><\/i>\t<a href=\"https:\/\/orcid.org\/0000-0002-2883-7326\"  class=\"\" target=\"_blank\">\n\t\t<span>https:\/\/orcid.org\/0000-0002-2883-7326<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/en\/team\/miguel-gonzalez-blanco\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: ONCOLOG\u00cdAObjetivos Comprender los mecanismos de regulaci\u00f3n de enzimas de reparaci\u00f3n del ADN en eucariotas y su coordinaci\u00f3n con la progresi\u00f3n del ciclo celular. L\u00edneas de investigaci\u00f3n &#8211; Estudio del [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":13373,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[512],"project_tag":[],"class_list":["post-22803","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-oncologia-en"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/22803","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/comments?post=22803"}],"version-history":[{"count":6,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/22803\/revisions"}],"predecessor-version":[{"id":45371,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project\/22803\/revisions\/45371"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/media\/13373"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/media?parent=22803"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project_category?post=22803"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/en\/wp-json\/wp\/v2\/project_tag?post=22803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}