{"id":27498,"date":"2023-03-23T12:45:33","date_gmt":"2023-03-23T11:45:33","guid":{"rendered":"https:\/\/www.idisantiago.es\/?post_type=project&p=27498"},"modified":"2025-11-06T09:29:20","modified_gmt":"2025-11-06T08:29:20","slug":"e055-cancer-predisposition-and-biomarkers","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/e055-cancer-predisposition-and-biomarkers\/","title":{"rendered":"E055 – Cancer predisposition and biomarkers"},"content":{"rendered":"

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\u00c1REA: \u00a0GEN\u00c9TICA Y BIOLOG\u00cdA DE SISTEMAS<\/a><\/p>\n

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Objectives<\/h3>\n

The main objective of the Cancer Predisposition and Biomarkers group is the characterization of the genetic factors of cancer. This information is of particular relevance when it comes to elucidating the biological mechanisms responsible for the appearance of tumors, which is essential for the development of new therapies. In addition, they allow us to devise risk stratification strategies that could be used to complement current population screening programs.<\/p>\n

Lines of research<\/h3>\n

The work of the Cancer Predisposition and Biomarkers group is focused on the analysis of how genomics together with other omic data can be used to identify those individuals most susceptible to developing cancer, mainly in the field of colorectal cancer. To do this, we use tools such as GWAS, TWAS and MWAS, which allow us to identify the genes responsible for the development of this disease.
Other lines of work in which we are currently involved include the intersection between single cell transcriptomics and liquid biopsy approaches in various types of tumors, transcriptomic and genomic measures of response to immunotherapy, the study of the mechanisms responsible for the appearance of resistance to treatment in cancer stem cells or the genetic predisposition to the appearance of adverse reactions to chemotherapeutic drugs.<\/p>\n

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Leader<\/strong>
Fern\u00e1ndez Rozadilla, Ceres<\/p>\n

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Members<\/strong>
Bamidele, Olalekan
Bernabeu Aracil, Mario
Carl\u00e9s Gonz\u00e1lez, Silvia
Mac\u00edas Real, Carmen
Santos Simoes, Ana Rita
V\u00e1zquez Fafi\u00e1n, Lara
Y\u00fccet\u00fcrk, Bet\u00fcl<\/p>\n<\/td>\n

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