{"id":27514,"date":"2023-03-23T13:03:11","date_gmt":"2023-03-23T12:03:11","guid":{"rendered":"https:\/\/www.idisantiago.es\/?post_type=project&p=27514"},"modified":"2026-02-27T10:25:28","modified_gmt":"2026-02-27T09:25:28","slug":"e056-metabolic-homeostasis-and-vascular-calcification","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/grupo-de-investigacion\/e056-metabolic-homeostasis-and-vascular-calcification\/","title":{"rendered":"E056 – Metabolic homeostasis and vascular calcification"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.16″ _module_preset=”default” width=”100%” custom_padding=”0px||||false|false” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”]\u00c1REA: CARDIOVASCULAR<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ _module_preset=”default” width=”100%” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.idisantiago.es\/wp-content\/uploads\/2023\/04\/IMG_3953-scaled.jpg” title_text=”IMG_3953″ disabled_on=”off|off|off” _builder_version=”4.19.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_toggle title=”Objectives and lines of research” disabled_on=”off|off|off” admin_label=”Objetivos y l\u00edneas de investigaci\u00f3n” _builder_version=”4.19.4″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”]<\/p>\n

Objectives<\/h3>\n

Vascular calcification, the pathological calcification of cardiovascular structures, is one of the most important factors determining patients’ mortality around the world. Although different mechanisms on pathogenesis of vascular calcification have been proposed, our understanding of the calcification pathogenesis is far from complete. However, in recent years, some risk factors are emerging, including elevated serum phosphorus and defective synthesis of pyrophosphate. In our laboratory, we are interested in the role of phosphate and pyrophosphate homeostasis in vascular calcification. Our laboratory aims to investigate the molecular mechanisms that control vascular calcification in the arterial wall in aging, chronic kidney disease, diabetes and accelerated aging (Hutchinson-Gilford Progeria Syndrome). We will also interest in evaluating new markers and risk factors for vascular calcification, which should help in the design of new diagnostic methods and new therapeutic strategies against this devastating disease. Given that vascular calcification is a problem with a remarkably high health and socioeconomic impact on society, our research will improve the health<\/p>\n

Lines of research<\/h3>\n