{"id":30193,"date":"2023-11-24T15:26:19","date_gmt":"2023-11-24T14:26:19","guid":{"rendered":"https:\/\/www.idisantiago.es\/?post_type=project&p=30193"},"modified":"2026-05-04T14:40:18","modified_gmt":"2026-05-04T12:40:18","slug":"e061-pharmacogenomics-and-drug-discovery-gendem","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/en\/project\/e061-pharmacogenomics-and-drug-discovery-gendem\/","title":{"rendered":"E061 \u2013 Pharmacogenomics and drug discovery (GenDeM)"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.16″ _module_preset=”default” width=”100%” custom_padding=”0px||||false|false” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

\u00c1REA: GENETICS AND SYSTEMS BIOLOGY<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ _module_preset=”default” width=”100%” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.idisantiago.es\/wp-content\/uploads\/2021\/11\/grupo_investigacion.jpg” title_text=”Corporate portrait of office workers and employees” disabled_on=”on|on|on” _builder_version=”4.16″ _module_preset=”default” disabled=”on” global_colors_info=”{}”][\/et_pb_image][et_pb_toggle title=”Objectives and lines of research” disabled_on=”off|off|off” admin_label=”Objetivos y l\u00edneas de investigaci\u00f3n” _builder_version=”4.21.0″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”]<\/p>\n

Objectives<\/h3>\n

\u200bThe main objective is the analysis of the genetic variability that influences the individual response to drug treatments. The purpose of the group is to advance knowledge in order to discover biomarkers linked both to the prevention of adverse reactions and to the optimization of the therapeutic effectiveness of existing drugs by identifying new therapeutic targets and pharmacological approaches. In this sense, the group particularly prioritizes drugs used in the treatment of prevalent diseases that are difficult to manage therapeutically and\/or high cost for the National Health System, ranging from psychiatric agents (including the use of opioids in the context of addiction) to cardiovascular and oncological agents. The main lines of research of the group have a highly translational approach and are oriented towards the direct application of the results to clinical practice, with the aim of enriching and perfecting, through Personalized Medicine, the current procedures, betting on analytical quality.<\/p>\n

Lines of research<\/h3>\n

-Search for biomarkers in Pharmacogenomics<\/p>\n

-Association of study variables with clinical characteristics of the patients<\/p>\n

-Prevention, prediction and quality in Pharmacogenetics<\/p>\n

-Identification and validation of new therapeutic targets and pharmacological approaches<\/p>\n

-Improvement of molecular analysis methods and strategies in diagnosis in Pharmacogenetics<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”Research team” admin_label=”Equipo investigador” _builder_version=”4.21.0″ _module_preset=”default” body_font=”|300|||||||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n\n\n\n
L\u00edder<\/strong>
Maro\u00f1as Amigo, Olalla<\/p>\n

 <\/p>\n

Members<\/strong>
Barral Ra\u00f1a, Alba Mar\u00eda
Dom\u00ednguez Medina, Eduardo
Esteban Carde\u00f1osa, Eva Mar\u00eda
Gil Rodr\u00edguez, Almudena
G\u00f3mez-Trigo Baldominos, Jes\u00fas
Mazaira Castro, Jos\u00e9 Alfredo
Quint\u00e1ns Castro, Beatriz
Recarey Rama, Sheila
S\u00e1nchez Fari\u00f1a, Patricia
Varela Liste, Mar\u00eda Jos\u00e9<\/p>\n

 <\/p>\n<\/td>\n

\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/et_pb_toggle][et_pb_toggle title=”Projects” disabled_on=”off|off|off” admin_label=”Proyectos (cambiar s\u00f3 codigo IDIS)” _builder_version=”4.21.0″ _module_preset=”default” body_font=”|300|||||||” locked=”off” global_colors_info=”{}”]<\/p>\nMejora de la calidad cl\u00ednica asistencial y la investigaci\u00f3n traslacional en Farmacogen\u00e9tica<\/strong>
C\u00f3digo del proyecto: PI25\/01349
Entidad financiadora: Instituto de Salud Carlos III
Duraci\u00f3n: 3 a\u00f1os
Cuant\u00eda: 254.605\u20ac
Investigador\/a principal: <\/a>
<\/p>\n

Intervenciones Cl\u00ednico-Farmacogeneticas en poblaci\u00f3n infanto-juvenil [Ingenia]<\/strong>
C\u00f3digo del proyecto: PMP21\/00065
Entidad financiadora: Instituto de Salud Carlos III
Duraci\u00f3n: 3 a\u00f1os
Cuant\u00eda: 380.000 \u20ac
Investigador\/a principal: <\/a>
<\/p>\n

Elaboraci\u00f3n de un protocolo de medicina personalizada para la administraci\u00f3n de metadona basada en perfiles farmacogen\u00e9ticos<\/strong>
C\u00f3digo del proyecto: PI22\/01166
Entidad financiadora: Instituto de Salud Carlos III
Duraci\u00f3n: 3 a\u00f1os
Cuant\u00eda: 66.550\u20ac
Investigador\/a principal: <\/a>
<\/p>\n

Evaluaci\u00f3n de una propuesta de Implementaci\u00f3n de la Farmacogen\u00e9tica en el Sistema Nacional de Salud para Salud Mental y Cardiovascular<\/strong>
Investigador\/a principal: <\/a>
<\/p>\n

Evaluaci\u00f3n de una propuesta de Implementaci\u00f3n de la Farmacogen\u00e9tica en el Sistema Nacional de Salud para Salud Mental y Cardiovascular [BioFRAM22]<\/strong>
C\u00f3digo del proyecto: PMP22\/00056
Entidad financiadora: Instituto de Salud Carlos III
Duraci\u00f3n: 3 a\u00f1os
Cuant\u00eda: 380.000\u20ac
Investigador\/a principal: <\/a>
<\/p>\n

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