{"id":13836,"date":"2022-02-22T15:35:35","date_gmt":"2022-02-22T14:35:35","guid":{"rendered":"https:\/\/www.idisantiago.es\/areas-de-investigacion\/a006-inflamacion\/"},"modified":"2023-04-13T10:58:59","modified_gmt":"2023-04-13T08:58:59","slug":"a006-inflamacion","status":"publish","type":"page","link":"https:\/\/www.idisantiago.es\/gl\/areas-de-investigacion\/a006-inflamacion\/","title":{"rendered":"A006 &#8211; Cardiovascular"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;T\u00edtulo&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;24px||0px||false|false&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; locked=&#8221;on&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>[et_pb_post_title meta=&#8221;off&#8221; featured_image=&#8221;off&#8221; _builder_version=&#8221;4.14.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_post_title]<\/p>\n<p>[\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; da_disable_devices=&#8221;off|off|off&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2020\/02\/inflamacion.jpg&#8221; title_text=&#8221;inflamacion&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;|300|||||||&#8221; header_font=&#8221;Roboto||||||||&#8221; text_orientation=&#8221;center&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: left;\">Obxectivos de investigaci\u00f3n<\/h2>\n<p style=\"text-align: left;\">O obxectivo xeral da \u00c1rea de Inflamaci\u00f3n consiste na busca de novas dianas terap\u00e9uticas e a mellora do manexo cl\u00ednico-terap\u00e9utico.<\/p>\n<ul>\n<li style=\"text-align: left;\">Estudo dos efectos das adipokinas e hormonas metab\u00f3licas na regulaci\u00f3n da viabilidade, o metabolismo e os procesos autof\u00e1xicos en cardiomiocitos humanos e murinos in vivo e in vitro.<\/li>\n<li style=\"text-align: left;\">Estudo da relaci\u00f3n entre niveis card\u00edacos e plasm\u00e1ticos de adipokinas e hormonas metab\u00f3licas, composici\u00f3n corporal e marcadores de risco e de pron\u00f3stico en patolox\u00edas cardiovasculares en pacientes con risco cardiovascular (s\u00edndrome metab\u00f3lico) e en pacientes con enfermidade cardiovascular establecida (insuficiencia cardiaca), co fin de contribuir a establecer a validez das adipokinas e hormonas metab\u00f3licas como novos biomarcadores tanto no s\u00edndrome metab\u00f3lico como na enfermidade cardiovascular establecida.<\/li>\n<li style=\"text-align: left;\">Estudo das adipokinas como novos potenciais biomarcadores de enfermidade e resposta a trataminto en pacientes con artrite reumatoide.<\/li>\n<li style=\"text-align: left;\">Utilidade de an\u00e1lise do l\u00edquido pleural na diagnose dos derrames pleurais. Estudar os efectos das adipokinas sobre factores de transcripci\u00f3n espec\u00edficos e os mecanismos de regulaci\u00f3n da autofaxia.<\/li>\n<li style=\"text-align: left;\">Identificaci\u00f3n e caracterizaci\u00f3n de novas adipokinas en c\u00e9lulas do sistema m\u00fasculo esquel\u00e9tico (cart\u00edlago, sinovia, m\u00fasculo, \u00f3so, texido adiposo periarticular).<\/li>\n<li style=\"text-align: left;\">Aplicaci\u00f3n da ecograf\u00eda tor\u00e1cica para identificar un pulm\u00f3n atrapado antes da drenaxe tor\u00e1cica.<\/li>\n<li style=\"text-align: left;\">Estudo do efecto de f\u00e1rmacos utilizados en Medicina Cardiovascular e Nutrac\u00e9utica a nivel cardiomiocitario.<\/li>\n<li style=\"text-align: left;\">Estudo dos efectos farmacol\u00f3xicos dos micronutrientes da fracci\u00f3n polifen\u00f3lica do aceite de oliva virxe extra.<\/li>\n<li style=\"text-align: left;\">Busca de par\u00e1metros (cl\u00ednicos e\/ou biol\u00f3xicos) que identifiquen tipos de resposta por parte da pleura.<\/li>\n<li style=\"text-align: left;\">Estudo dos mecanismos fisiopatox\u00e9nicos de enfermidades reum\u00e1ticas (Artritis Reumatoide, Lupus Eritematoso Sist\u00e9mico e Osteoporosis). Identificaci\u00f3n e validaci\u00f3n de novas dianas terap\u00e9uticas na Artrite Reumatoide.<\/li>\n<li style=\"text-align: left;\">Identificaci\u00f3n e validaci\u00f3n de biomarcadores de resposta \u00f3 tratamento nos pacientes con artrite reumatoide.<\/li>\n<li style=\"text-align: left;\">Identificaci\u00f3n e caracterizaci\u00f3n de factores xen\u00e9ticos de susceptibilidade \u00e1 artrose.<\/li>\n<li style=\"text-align: left;\">Caracterizaci\u00f3n de factores xen\u00e9ticos de susceptibilidade a lupus eritematoso sist\u00e9mico e a s\u00faa relaci\u00f3n coa cl\u00ednica, as\u00ed como a s\u00faa variabilidade na poboaci\u00f3n europea.<\/li>\n<li style=\"text-align: left;\">Interacci\u00f3n entre sistema inmune e sistema m\u00fasculo esquel\u00e9tico: Papel das adipokinas na modulaci\u00f3n das c\u00e9lulas T reguladoras (Treg) e outras subpoboaci\u00f3ns linfocitarias.<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; 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font-weight: 200; }<\/style><div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" > <div id=\"sptp-10200\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" > <div class=\"sp-team-pro-page-loading-image\"><\/div> <div class=\"sptp-grid\"> <div class=\"sptp-row \"> <div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\" data-member=\"16855\"> <div class=\"sptp-member border-bg-around-member sptp-bottom-content sptp-square\"> <a class=\"sptp-member-avatar \" href=https:\/\/www.idisantiago.es\/gl\/team\/jose-ramon-gonzalez-juanatey\/ target=_blank > <div class=\"sptp-member-avatar-img-area\" data-id=\"16855\"> <div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image \"> <div class=\"sptp-overflow-h\"> <div class=\"sptp-icon text-center\"> <i class=\"fa fa-plus\"><\/i> <\/div> <img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img \" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Gonzalez-Juanatey.jpg\" alt=\"Jos\u00e9 Ram\u00f3n Gonz\u00e1lez Juanatey\" width=\"320\" height=\"483\"> <\/div> <\/div> <\/div> <\/a> <div class=\"sptp-member-name \"> <h2 class=\"sptp-name\">Jos\u00e9 Ram\u00f3n Gonz\u00e1lez Juanatey<\/h2><\/div> <div class=\"sptp-member-desc\"> <p>O...<\/p> <\/div> <div class=\"sptp-member-email\"> <i class=\"fa fa-envelope\"><\/i> <a href=\"#0\" class=\"\"> <span>jose.ramon.gonzalez.juanatey@sergas.es<\/span> <\/a> <\/div> <div class=\"sptp-member-phone\"> <i class=\"fa fa-phone\"><\/i> <a href=\"#0\" class=\"\" > <span>(+34) 981 950 793<\/span> <\/a> <\/div> <div class=\"sptp-member-website\"> <i class=\"fa fa-globe\"><\/i> <a href=\"http:\/\/orcid.org\/0000-0001-9681-3388\" class=\"\" target=\"_blank\"> <span>http:\/\/orcid.org\/0000-0001-9681-3388<\/span> <\/a> <\/div> <div class=\"sptp-read-more-button\"> <a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/gl\/team\/jose-ramon-gonzalez-juanatey\/\" target=\"_blank\" > + INFO <\/a> <\/div> <\/div> <\/div> <\/div> <\/div> <\/div> <\/div> \n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Co-l\u00edder de \u00e1rea&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h2>Co-l\u00edder de \u00e1rea<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team&#8221; _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; 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h2, h4,.sptp-member-name-title { font-family: 'Roboto'; } #sptp-7994 .sptp-member-name .sptp-member-name-title{ color:#8A7A0F; } #sptp-7994 .sptp-member-profession .sptp-jop-title{ color:#9EA1B3; font-weight: 200; }<\/style><div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" > <div id=\"sptp-24332\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" > <div class=\"sp-team-pro-page-loading-image\"><\/div> <div class=\"sptp-grid\"> <div class=\"sptp-row \"> <div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\" data-member=\"24297\"> <div class=\"sptp-member border-bg-around-member sptp-bottom-content sptp-square\"> <a class=\"sptp-member-avatar \" href=https:\/\/www.idisantiago.es\/gl\/team\/moises-rodriguez-manero\/ target=_blank > <div class=\"sptp-member-avatar-img-area\" data-id=\"24297\"> <div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image \"> <div class=\"sptp-overflow-h\"> <div class=\"sptp-icon text-center\"> <i class=\"fa fa-plus\"><\/i> <\/div> <img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img \" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2025\/09\/MoisesRodriguez-scaled.jpg\" alt=\"Mois\u00e9s Rodr\u00edguez Ma\u00f1ero\" width=\"1920\" height=\"2560\"> <\/div> <\/div> <\/div> <\/a> <div class=\"sptp-member-name \"> <h2 class=\"sptp-name\">Mois\u00e9s Rodr\u00edguez Ma\u00f1ero<\/h2><\/div> <div class=\"sptp-member-desc\"> <\/div> <div class=\"sptp-read-more-button\"> <a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/gl\/team\/moises-rodriguez-manero\/\" target=\"_blank\" > + INFO <\/a> <\/div> <\/div> <\/div> <\/div> <\/div> <\/div> <\/div> \n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Logos_internas&#8221; _builder_version=&#8221;4.14.7&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(255,255,255,0)&#8221; 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