{"id":16568,"date":"2022-01-14T12:30:28","date_gmt":"2022-01-14T11:30:28","guid":{"rendered":"https:\/\/www.idisantiago.es\/?post_type=project&#038;p=16568"},"modified":"2025-06-11T13:19:01","modified_gmt":"2025-06-11T11:19:01","slug":"e054-epitranscriptomica-y-envejecimiento","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/gl\/grupo-de-investigacion\/e054-epitranscriptomica-y-envejecimiento\/","title":{"rendered":"E054 &#8211; Epitranscript\u00f3mica e envellecemento"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u00c1REA: \u00a0<a href=\"https:\/\/www.idisantiago.es\/gl\/areas-de-investigacion\/a002-genetica-y-biologia-de-sistemas\/\">XEN\u00c9TICA E BIOLOX\u00cdA DE SISTEMAS<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/E054-Orig.jpg&#8221; title_text=&#8221;E054 Orig&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Obxectivos e li\u00f1as de investigaci\u00f3n&#8221; admin_label=&#8221;Obxectivos e li\u00f1as de investigaci\u00f3n&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Obxectivos<\/h3>\n<p>O noso grupo de investigaci\u00f3n est\u00e1 centrado en identificar novos mecanismos moleculares involucrados en definir a identidade celular, tanto en modelos fisiol\u00f3xicos como patol\u00f3xicos. En particular, estamos interesados en estudar o papel das modificaci\u00f3ns de ARN (Epitranscript\u00f3micas) e a s\u00faa interrelaci\u00f3n coas modificaci\u00f3ns na cromatina (Epigen\u00e9ticas) na biolox\u00eda de c\u00e9lulas pluripotentes, durante o envellecemento e o rexuvenecemento celular.<\/p>\n<h3>Li\u00f1as de investigaci\u00f3n<\/h3>\n<ul>\n<li>Mecanismos epixen\u00e9ticos e epitranscript\u00f3micos involucrados no envellecemento e enfermidades asociadas.<\/li>\n<li>Impacto da modificaci\u00f3n hm5C en el ARN no envellecemento celular en contexto de obesidade.<\/li>\n<li>Funci\u00f3n de TET2 en ARN en envellecemento e rexuvenecemento celular.<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Equipo investigador&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<table style=\"width: 100%; border-collapse: collapse; border-style: hidden;\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\">\n<p><strong>L\u00edder<\/strong><br \/>Guallar Artal, Diana<\/p>\n<\/td>\n<td style=\"width: 50%;\">\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Membros<\/strong><br \/>Cort\u00e9s Coego, Alba<br \/>de la Parte Rodr\u00edguez, Cristina<br \/>Martins Moreira, Tiago Manuel<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Proxectos&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publicaci\u00f3ns&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Covelo-Molares H, Souto Y, Fidalgo M, Guallar D. <strong>A Simple, Rapid, and Cost-Effective Method for Loss-of-Function Assays in Pluripotent Cells.<\/strong> Methods Mol Biol. 2021 Oct 6. <strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1007\/7651_2021_434\">doi: 10.1007\/7651_2021_434.<\/a><\/span><\/strong><\/li>\n<li>Wang J, Yu H, Ma Q, Zeng P, Wu D, Hou Y, Liu X, Jia L, Sun J, Chen Y, Guallar D, Fidalgo M, Chen J, Yu Y, Jiang S, Li F, Zhao C, Huang X, Wang J, Li C, Sun Y, Zeng X, Zhang W, Miao Y, Ding J. <strong>Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions.<\/strong> <em>Cell Stem Cell.<\/em> 2021 Oct 7;28(10):1868-1883.e11. <strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.stem.2021.04.023\">doi: 10.1016\/j.stem.2021.04.023<\/a>.<\/span> <\/strong>Epub 2021 May 25.<\/li>\n<li>Garcia-Outeiral V, De La Parte C, Fidalgo M, Guallar D. <strong>The Complexity of TET2 Functions in Pluripotency and Development.<\/strong> <em>Frontiers in Cell and Developmental Biology<\/em>. 2021 Jan 18. <strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.3389\/fcell.2020.630754\">doi:10.3389\/fcell.2020.630754<\/a>.<\/span><\/strong><\/li>\n<li>Lan J, Rajan N, Bizet M, Penning A, Singh NK, Guallar D, Calonne E, Li Greci A, Bonvin E, Deplus R, Hsu PJ, Nachtergaele S, Ma C, Song R, Fuentes-Iglesias A, Hassabi B, Putmans P, Mies F, Menschaert G, Wong JJL, Wang J, Fidalgo M, Yuan B, Fuks F. F<strong>unctional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation<\/strong>. <em>Nature Communications<\/em> 2020 Oct 2;11(1):4956.<strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1038\/s41467-020-18729-6\"> doi: 10.1038\/s41467-020-18729-6<\/a><\/span><\/strong>.<\/li>\n<li>Fuentes-Iglesias A, Garcia-Outeiral V, Pardavila JA, Wang J*, Fidalgo M*, Guallar D*.<strong> An Optimized Immunoprecipitation Protocol for Assessing Protein-RNA Interactions In Vitro<\/strong>. <em>STAR Protocols<\/em> 2020 Sep 18;1(2):100093. <strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.xpro.2020.100093\">doi: 10.1016\/j.xpro.2020.100093<\/a><\/span><\/strong>. (*Co-corresponding authors)<\/li>\n<li>Guallar D*,#, Fuentes-Iglesias A#, Souto Y, Ameneiro C, Freire-Agulleiro O, Pardavila JA, Escudero A, Garcia-Outeiral V, Moreira T, Saenz C, Xiong H, Liu D, Xiao S, Hou Y, Wu K, Torrecilla D, Hartner JC, Blanco MG, Lee LJ, L\u00f3pez M, Walkley CR, Wang J*, Fidalgo M*. <strong>ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress.<\/strong>\u00a0<em>Cell Stem Cell.<\/em> 2020 Aug 6;27(2):300-314.e11.<span style=\"color: #808000;\"> <strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.stem.2020.04.016\">doi: 10.1016\/j.stem.2020.04.016<\/a><\/strong><\/span>. (#Co-first, *Co-corresponding author).<\/li>\n<li>Ameneiro C, Moreira T, Fuentes-Iglesias A, Coego A, Garcia-Outeiral V, Escudero A, Torrecilla D, Mulero-Navarro S, Carvajal-Gonzalez JM, Guallar D*, Fidalgo M*. <strong>BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells<\/strong>. <em>Life Science Alliance<\/em>. 2020 Apr 13;3(5):e201900534. <strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.26508\/lsa.201900534\">doi: 10.26508\/lsa.201900534<\/a><\/span><\/strong>.*Co-corresponding authors.<\/li>\n<li>Folgueira C, Beiroa D, Porteiro B, Duquenne M, Puighermanal E, Fondevila MF, Barja-Fern\u00e1ndez S, Gallego R, Hern\u00e1ndez-Bautista R, Castelao C, Senra A, Seoane P, G\u00f3mez N, Aguiar P, Guallar D, Fidalgo M, Romero-Pico A, Adan R, Blouet C, Labandeira-Garc\u00eda JL, Jeanrenaud F, Kallo I, Liposits Z, Salvador J, Prevot V, Dieguez C, Lopez M, Valjent E, Fr\u00fchbeck G, Seoane LM, Nogueiras R. <strong>Hypothalamic dopamine signaling regulates brown fat thermogenesis.<\/strong> <em>Nature Metabolism.<\/em> 2019 Aug;1(8):811-829. <span style=\"color: #808000;\"><strong>doi: 10.1038\/s42255-019-0099-7<\/strong><\/span>.<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Web do grupo&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>https:\/\/www.usc.es\/cimus\/es\/investigacion\/grupos-de-investigacion\/epitranscriptomics-ageing<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Palabras clave&#8221; admin_label=&#8221;Palabras clave&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Modificaciones ARN, epitranscript\u00f3mica, c\u00e9lulas madre, envejecimiento, epigen\u00e9tica, retrovirus end\u00f3genos<\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Investigadora l\u00edder<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;on&#8221; 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.sptp-arrow, .sptp-mosaic .sptp-col-lg-2.sptp-member:nth-child(4n) .sptp-arrow, .sptp-mosaic .sptp-col-lg-2.sptp-member:nth-child(4n-1) .sptp-arrow, .sptp-mosaic .sptp-col-lg-3.sptp-member:nth-child(6n) .sptp-arrow, .sptp-mosaic .sptp-col-lg-3.sptp-member:nth-child(6n-1) .sptp-arrow, .sptp-mosaic .sptp-col-lg-3.sptp-member:nth-child(6n-2) .sptp-arrow, .sptp-mosaic .sptp-col-lg-4.sptp-member:nth-child(8n) .sptp-arrow, .sptp-mosaic .sptp-col-lg-4.sptp-member:nth-child(8n-1) .sptp-arrow, .sptp-mosaic .sptp-col-lg-4.sptp-member:nth-child(8n-2) .sptp-arrow, .sptp-mosaic .sptp-col-lg-4.sptp-member:nth-child(8n-3) .sptp-arrow { left: auto; right: -20px; border-left-width: 20px; border-right-width: 0; } }div, h2, h4,.sptp-member-name-title { font-family: 'Roboto'; } #sptp-7994 .sptp-member-name .sptp-member-name-title{ color:#8A7A0F; } #sptp-7994 .sptp-member-profession .sptp-jop-title{ color:#9EA1B3; font-weight: 200; }<\/style><div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" > <div id=\"sptp-10610\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" > <div class=\"sp-team-pro-page-loading-image\"><\/div> <div class=\"sptp-grid\"> <div class=\"sptp-row \"> <div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\" data-member=\"18934\"> <div class=\"sptp-member border-bg-around-member sptp-bottom-content sptp-square\"> <a class=\"sptp-member-avatar \" href=https:\/\/www.idisantiago.es\/gl\/team\/diana-guallar-artal\/ target=_blank > <div class=\"sptp-member-avatar-img-area\" data-id=\"18934\"> <div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image \"> <div class=\"sptp-overflow-h\"> <div class=\"sptp-icon text-center\"> <i class=\"fa fa-plus\"><\/i> <\/div> <img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img \" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Diana-Guallar-300x320.jpg\" alt=\"Diana Guallar Artal\" width=\"300\" height=\"320\"> <\/div> <\/div> <\/div> <\/a> <div class=\"sptp-member-name \"> <h2 class=\"sptp-name\">Diana Guallar Artal<\/h2><\/div> <div class=\"sptp-member-email\"> <i class=\"fa fa-envelope\"><\/i> <a href=\"#0\" class=\"\"> <span>diana.guallar@usc.es<\/span> <\/a> <\/div> <div class=\"sptp-member-phone\"> <i class=\"fa fa-phone\"><\/i> <a href=\"#0\" class=\"\" > <span>(+34) 881 815 385<\/span> <\/a> <\/div> <div class=\"sptp-member-website\"> <i class=\"fa fa-globe\"><\/i> <a href=\"https:\/\/orcid.org\/0000-0001-5834-7507\" class=\"\" target=\"_blank\"> <span>https:\/\/orcid.org\/0000-0001-5834-7507<\/span> <\/a> <\/div> <div class=\"sptp-read-more-button\"> <a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/gl\/team\/diana-guallar-artal\/\" target=\"_blank\" > + INFO <\/a> <\/div> <\/div> <\/div> <\/div> <\/div> <\/div> <\/div> \n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: \u00a0XEN\u00c9TICA E BIOLOX\u00cdA DE SISTEMASObxectivos O noso grupo de investigaci\u00f3n est\u00e1 centrado en identificar novos mecanismos moleculares involucrados en definir a identidade celular, tanto en modelos fisiol\u00f3xicos como patol\u00f3xicos. [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":16386,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[507],"project_tag":[],"class_list":["post-16568","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-genetica-y-biologia-de-sistemas-gl"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/16568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/comments?post=16568"}],"version-history":[{"count":0,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/16568\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media\/16386"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media?parent=16568"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_category?post=16568"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_tag?post=16568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}