{"id":18720,"date":"2022-03-21T14:39:53","date_gmt":"2022-03-21T13:39:53","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/c009-investigacion-traslacional-en-enfermidades-do-aparato-dixestivo\/"},"modified":"2026-01-12T13:24:28","modified_gmt":"2026-01-12T12:24:28","slug":"c009-investigacion-traslacional-en-enfermidades-do-aparato-dixestivo","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/gl\/grupo-de-investigacion\/c009-investigacion-traslacional-en-enfermidades-do-aparato-dixestivo\/","title":{"rendered":"C009 \u2013 Investigaci\u00f3n Traslacional en Enfermidades do Aparato Dixestivo"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u00c1REA:\u00a0<a href=\"https:\/\/www.idisantiago.es\/gl\/areas-de-investigacion\/a002-genetica-y-biologia-de-sistemas\/\">XEN\u00c9TICA E BIOLOX\u00cdA DE SISTEMAS<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2021\/11\/grupo_investigacion.jpg&#8221; title_text=&#8221;Corporate portrait of office workers and employees&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Obxectivos e li\u00f1as de investigaci\u00f3n&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Objetivos y l\u00edneas de investigaci\u00f3n&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Obxectivos<\/h3>\n<p>O noso grupo de investigaci\u00f3n desenvolve l\u00edi\u00f1as de investigaci\u00f3n cl\u00ednica e investigaci\u00f3n traslacional en enfermidades do aparato dixestivo, en concreto nas \u00e1reas que a continuaci\u00f3n se enumeran.<\/p>\n<ul>\n<li><strong>Bases etiopatoxen\u00e9ticas e fisiopatol\u00f3xicas das enfermidades do p\u00e1ncreas exocrino e as s\u00faas implicaci\u00f3ns diagn\u00f3sticas e terap\u00e9uticas.<\/strong> Efecto de h\u00e1bitos t\u00f3xicos (consumo de alcol e tabaco) sobre o risco de pancreatite cr\u00f3nica, a idade e o modo de presentaci\u00f3n cl\u00ednica da enfermidade, a s\u00faa evoluci\u00f3n cl\u00ednica e pron\u00f3stico, e o risco de desenvolvemento do cancro de p\u00e1ncreas. Factores xen\u00e9ticos de predisposici\u00f3n \u00f3 desenvolvemento de pancreatite cr\u00f3nica e cancro de p\u00e1ncreas (mutaci\u00f3ns dos xenes do tripsin\u00f3xeno cati\u00f3nico, SPINK1 e CFTR). Estudo do proceso de fibrox\u00e9nese pancre\u00e1tica en pancreatite cr\u00f3nica e a s\u00faa cuantificaci\u00f3n mediante t\u00e9cnicas serol\u00f3xicas e elastogr\u00e1ficas. Estudo molecular e biol\u00f3xico do cancro de p\u00e1ncreas e as s\u00faas implicaci\u00f3ns cl\u00ednicas sobre as caracter\u00edsticas do tumor (grao de diferenciaci\u00f3n celular e extensi\u00f3n locorrexional), a supervivencia do enfermo, e o seu potencial aplicaci\u00f3n como dianas terap\u00e9uticas. Efecto potencial de bacterias citot\u00f3xicas ailladas de tumores pancre\u00e1ticos sobre o proceso de carcinox\u00e9nese en cancro de p\u00e1ncreas.<\/li>\n<li><strong>Bases epidemiol\u00f3xicas, etiopatox\u00e9nicas e terap\u00e9uticas da enfermidade inflamatoria intestinal (enfermidade de Crohn e colite ulcerosa).<\/strong> Epidemiolox\u00eda da enfermidade inflamatoria intestinal e a s\u00faa relaci\u00f3n con h\u00e1bitos diet\u00e9ticos, t\u00f3xicos e h\u00e1bitos de vida. Papel da infecci\u00f3n por bacterias psicotr\u00f3ficas na etiopatoxenia da enfermidade de Crohn. Eficacia de novos f\u00e1rmacos inmunomoduladores no tratamento de pacientes con enfermidade inflamatoria intestinal corticodependente e corticorresistente.<\/li>\n<li><strong>Impacto de carcinoma hepatocelular e o seu tratamento percut\u00e1neo local na supervivencia dos pacientes en listas de espera para transplante hep\u00e1tico.<\/strong> Eficacia antitumoral e perfil de seguridade da inxecci\u00f3n percut\u00e1nea de etanol como tratamento neoadxuvante do carcinoma hepatocelular en lista de espera de transplante hep\u00e1tico. Eficacia antitumoral da radiofrecuencia percut\u00e1nea como tratamento neoadxuvante do carcinoma hepatocelular e das met\u00e1stases hep\u00e1ticas de tumores de outras localizaci\u00f3ns.<\/li>\n<\/ul>\n<p>&nbsp;[\/et_pb_toggle][et_pb_toggle title=&#8221;Equipo investigador&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><strong>L\u00edder<\/strong><br \/>Dom\u00ednguez Mu\u00f1oz, Juan Enrique<\/p>\n<p><strong>Col\u00edder\u00a0<\/strong><br \/>Pazos Randulfe, Yolanda<\/p>\n<table style=\"width: 100%; border-collapse: collapse; border-style: hidden;\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\"><strong>Membros<\/strong><br \/>\u00c1lvarez Castro, Ana Mar\u00eda<br \/>Barreiro de Acosta, Manuel<br \/>Bast\u00f3n Rey, Iria<br \/>Calvi\u00f1o Su\u00e1rez, Cristina<br \/>D\u00edaz Arg\u00fceso, Laura<br \/>Dom\u00ednguez Novoa, Y\u00e9ssica<br \/>Fern\u00e1ndez de Castroagud\u00edn, Javier<br \/>Fern\u00e1ndez P\u00e9rez, Jos\u00e9 Aquilino<br \/>Ferreiro Iglesias, Roc\u00edo<br \/>Galego Fern\u00e1ndez, Marco<br \/>Iglesias Garc\u00eda, Julio<br \/>Jim\u00e9nez S\u00e1nchez, Javier<br \/>Lari\u00f1o Noia, Jos\u00e9<br \/>Leal L\u00f3pez, Sa\u00fal<br \/>L\u00f3pez D\u00edaz, Javier<br \/>Loureiro Veira, Marti\u00f1o<\/td>\n<td style=\"width: 50%;\">Mac\u00edas Garc\u00eda, Fernando<br \/>Mart\u00edn Carreras-Presas, Francisco Luis<br \/>Mart\u00ednez-Seara V\u00e1zquez, Xurxo Francisco<br \/>Meijide Fern\u00e1ndez, Ignacio<br \/>Mejuto Fern\u00e1ndez, Rafael<br \/>M\u00edguez S\u00e1nchez, Patricia<br \/>Molina P\u00e9rez, Esther<br \/>Monteserin Ron, Luzdivina<br \/>Montoto Meijide, Rodrigo<br \/>Nieto Garc\u00eda, Laura<br \/>Otero Fraga, Mar\u00eda Jos\u00e9<br \/>Otero Iglesias, M\u00f3nica<br \/>Otero Iglesias, Paula<br \/>Porto Silva, Mar\u00eda del Sol<br \/>Quiroga Casti\u00f1eira, Adriano<br \/>Rama Fern\u00e1ndez, Alberto<br \/>Vallejo Senra, Nicolau<br \/>Varo P\u00e9rez, Evaristo<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Proxectos&#8221; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; disabled=&#8221;on&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publicaci\u00f3ns&#8221; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Publicaci\u00f3n 1<\/li>\n<li>Publicaci\u00f3n 2<\/li>\n<li>Etc.<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Web do grupo&#8221; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>https:\/\/<\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Investigador l\u00edder<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-10549\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"17463\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/gl\/team\/juan-enrique-dominguez-munoz\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"17463\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/JEnriqueDominguez_CR-320x320.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/JEnriqueDominguez_CR-320x320.jpg\" alt=\"Juan Enrique Dom\u00ednguez Mu\u00f1oz\" width=\"320\" height=\"320\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tJuan Enrique Dom\u00ednguez Mu\u00f1oz\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/gl\/team\/juan-enrique-dominguez-munoz\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Investigadora col\u00edder<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-44064\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"44065\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/gl\/team\/yolanda-pazos-randulfe\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"44065\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/plugins\/wp-team-pro\/src\/Frontend\/img\/Placeholder-Image.png\" src=\"https:\/\/www.idisantiago.es\/wp-content\/plugins\/wp-team-pro\/src\/Frontend\/img\/Placeholder-Image.png\" alt=\"Yolanda Pazos Randulfe\" width=\"600\" height=\"450\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tYolanda Pazos Randulfe\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>yolanda.pazos.randulfe@sergas.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/gl\/team\/yolanda-pazos-randulfe\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA:\u00a0XEN\u00c9TICA E BIOLOX\u00cdA DE SISTEMASObxectivos O noso grupo de investigaci\u00f3n desenvolve l\u00edi\u00f1as de investigaci\u00f3n cl\u00ednica e investigaci\u00f3n traslacional en enfermidades do aparato dixestivo, en concreto nas \u00e1reas que a continuaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":13039,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[507],"project_tag":[],"class_list":["post-18720","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-genetica-y-biologia-de-sistemas-gl"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/18720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/comments?post=18720"}],"version-history":[{"count":24,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/18720\/revisions"}],"predecessor-version":[{"id":44120,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/18720\/revisions\/44120"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media\/13039"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media?parent=18720"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_category?post=18720"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_tag?post=18720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}