{"id":19220,"date":"2022-01-18T15:15:57","date_gmt":"2022-01-18T14:15:57","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/c028-reumatologia-experimental-y-observacional\/"},"modified":"2026-02-25T08:30:48","modified_gmt":"2026-02-25T07:30:48","slug":"c028-reumatologia-experimental-y-observacional","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/gl\/grupo-de-investigacion\/c028-reumatologia-experimental-y-observacional\/","title":{"rendered":"C028 &#8211; Reumatolox\u00eda Experimental e Observacional"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.17.6&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]\u00c1REA: <a href=\"https:\/\/www.idisantiago.es\/gl\/areas-de-investigacion\/a007-infectoloxia-inflamacion-e-vacinas\/\">INFECTOLOX\u00cdA, INFLAMACI\u00d3N E VACINAS<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Reumatologia-Experimental-y-Observacional-scaled.jpg&#8221; title_text=&#8221;cof&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Obxectivos e li\u00f1as de investigaci\u00f3n&#8221; admin_label=&#8221;Obxectivos e li\u00f1as de investigaci\u00f3n&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Obxectivos<\/h3>\n<p>O obxectivo do noso grupo \u00e9 mellorar o manexo cl\u00ednico dos pacientes con artrite reumatoide utilizando estudos observacionais e experimentais con ferramentas xen\u00e9ticas, de biolox\u00eda celular e molecular.<br \/>En concreto, pret\u00e9ndese por un lado encontrar biomarcadores de mal pron\u00f3stico nos pacientes con artrite de recente comezo e de detecci\u00f3n de manifestaci\u00f3ns graves. Por outro lado, pret\u00e9ndese identificar novas dianas terap\u00e9uticas para o desenvolvemento de terapias que consigan controlar a enfermidade nos pacientes que non responden \u00f3s tratamentos actuais.<\/p>\n<h3>Li\u00f1as de investigaci\u00f3n<\/h3>\n<p>Na actualidade o grupo est\u00e1 traballando en tres li\u00f1as de investigaci\u00f3n na artrite reumatoide:<\/p>\n<p>1) Busca de biomarcadores de clasificaci\u00f3n e pron\u00f3stico na primeira visita dos pacientes con artrite inflamatoria.<br \/>2) Busca de biomarcadores de predicci\u00f3n dunha manifestaci\u00f3n pouco frecuente e grave da artrite reumatoide, a enfermidade pulmonar intersticial.<br \/>3) Busca de novas dianas terap\u00e9uticas na artrite reumatoide mediante o estudo da v\u00eda de sinalizaci\u00f3n de WNT5A e das pseudoquinasas TRIB.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Equipo investigador&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<table style=\"width: 100%; border-collapse: collapse; border-style: hidden;\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\"><strong>L\u00edder<\/strong><br \/>Gonz\u00e1lez Mart\u00ednez-Pedrayo, Antonio<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Membros<\/strong><br \/>Campos Franco, Joaqu\u00edn<br \/>Conde Muro, Carmen<br \/>D\u00edaz Garel, Juan Jos\u00e9<br \/>Kaczmarczyk, Bartosz<br \/>Peinado Mu\u00f1oz, Marina<\/p>\n<\/td>\n<td style=\"width: 50%;\">\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Proxectos&#8221; admin_label=&#8221;Proxectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publicaci\u00f3ns&#8221; admin_label=&#8221;Publicaci\u00f3ns&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Regueiro C, Casares-Marfil D, Lundberg K, Knevel R, Acosta-Herrera M, Rodriguez-Rodriguez L, Lopez-Mejias R, Perez-Pampin E, Triguero-Martinez A, Nu\u00f1o L, Ferraz-Amaro I, Rodriguez-Carrio J, Lopez-Pedrera R, Robustillo-Villarino M, Casta\u00f1eda S, Remuzgo-Martinez S, Alperi M, Alegre-Sancho JJ, Balsa A, Gonzalez-Alvaro I, Mera A, Fernandez-Gutierrez B, Gonzalez-Gay MA, Trouw L, Gr\u00f6nwall C, Padyukov L, Martin J, Gonzalez A. <strong>HLA-B*08 identified as the most associated MHC locus for anti-carbamylated protein antibody-positive\/anti-CCP-negative rheumatoid arthritis<\/strong>. <em>Arthritis Rheumatol<\/em>. 2021; 73(6): 963-969. Dec 31. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1002\/art.41630\">doi: 10.1002\/art.41630<\/a><\/strong><\/span>. PMID: 33381897<\/li>\n<li>Regueiro C, Nu\u00f1o L, Triguero-Martinez A, Ortiz AM, Villalba A, B\u00f3veda MD, Mart\u00ednez-Feito A, Conde C, Balsa A, Gonz\u00e1lez-Alvaro I, Gonzalez A.<strong> Increased disease activity in early arthritis patients with anti-carbamylated protein antibodies<\/strong>.<em>\u00a0Sci Rep<\/em>. 2021 May 11;11(1):9945. <strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1038\/s41598-021-89502-y\">doi: 10.1038\/s41598-021-89502-y<\/a><\/span><\/strong>. PMID: 33976334<\/li>\n<li>Rodriguez-Trillo A, Mosquera N, Pena C, Rivas-Tobio F, Mera-Varela A, Gonzalez A, Conde C. <strong>Non-canonical WNT5A signaling through RYK contributes to aggressive phenotype of the rheumatoid fibroblast-like synoviocytes<\/strong>. <em>Front Immunol<\/em> 2020. 11:555245. <strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.3389\/fimmu.2020.555245\">doi: 10.3389\/fimmu.2020.555245 \u00a0<\/a><\/span><\/strong><\/li>\n<li><span style=\"color: #000000;\">Regueiro C, Rodriguez-Rodriguez L, Lopez-Mejias R, Nu\u00f1o L, Triguero-Martinez A, Perez-Pampin E, Corrales A, Villalba A, Lopez-Golan Y, Abasolo L, Remuzgo-Mart\u00ednez S, Ortiz AM, Herranz E, Mart\u00ednez-Feito A, Conde C, Mera-Varela A, Balsa A, Gonzalez-Alvaro I, \u00c1ngel Gonz\u00e1lez-Gay M, Fernandez-Gutierrez B, Gonzalez A <\/span><strong>A predominant involvement of the triple seropositive patients and others with rheumatoid factor in the association of smoking with rheumatoid arthritis<\/strong>. <em>Sci Rep.<\/em> 2020;10:3355. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1038\/s41598-020-60305-x\">doi:10.1038\/s41598-020-60305-x<\/a><\/strong><\/span>. PMID: 32098994.<\/li>\n<li>Mosquera N, Rodriguez-Trillo A, Blanco FJ, Mera-Varela A, Gonzalez A, Conde C. <strong>All-Trans Retinoic Acid Inhibits Migration and Invasiveness of Rheumatoid Fibroblast-Like Synoviocytes<\/strong>.<em> J Pharmacol Exp Ther<\/em>. 2020 Feb;372(2):185-192. <strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1124\/jpet.119.261370\">doi: 10.1124\/jpet.119.261370<\/a><\/span><\/strong>. Epub 2019 Dec 4. PMID: 31801802<\/li>\n<li>Rodriguez-Mart\u00ednez L, Bang H, Regueiro C, Nu\u00f1o L, Triguero-Martinez A, Peiteado D, Ortiz AM, Villalba A, Martinez-Feito A, Balsa A, Gonzalez-Alvaro I, Gonzalez A. <strong>Improved classification of rheumatoid arthritis with a score including anti-acetylated ornithine antibodies<\/strong>. <em>Sci Rep.<\/em> 2020 Nov 6;10(1):19263. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1038\/s41598-020-73919-y\">doi: 10.1038\/s41598-020-73919-y<\/a><\/strong><\/span>. PMID: 33159095<\/li>\n<li>Regueiro C, Rodriguez-Rodriguez L, Triguero-Martinez A, Nu\u00f1o L, Casta\u00f1o-Nu\u00f1ez AL, Villalva A, Perez-Pampin E, Lopez-Golan Y, Abasolo L, Ortiz AM, Herranz E, Pascual-Salcedo D, Mart\u00ednez-Feito A, Boveda MD, Gomez-Reino JJ, Mart\u00edn J, Gonzalez-Escribano MF, Fernandez-Gutierrez B, Balsa A, Gonzalez-Alvaro I, Gonzalez A. <strong>Specific Association of HLA-DRB1*03 With Anti-Carbamylated Protein Antibodies in Patients With Rheumatoid Arthritis<\/strong>. <em>Arthritis Rheumatol.<\/em> 2019 Mar;71(3):331-339. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1002\/art.40738\">doi: 10.1002\/art.40738<\/a><\/strong><\/span>.<\/li>\n<li>Regueiro C, Rodr\u00edguez-Mart\u00ednez L, Nu\u00f1o L, Ortiz AM, illalba A, Pascual-Salcedo D, Mart\u00ednez-Feito A, Gonz\u00e1lez-Alvaro I, Balsa A, Gonzalez A.<strong> Improved RA classification among early arthritis patients with the concordant pesence of three RA autoantibodies: analysis in two early arthritis clinics<\/strong>.<em> Arthritis Res Ther.<\/em> 2019 Dec 11;21(1):280. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1186\/s13075-019-2079-4\">doi: 10.1186\/s13075-019-2079-4<\/a><\/strong><\/span>.PMID: 31829260<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Web do grupo&#8221; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Web do grupo&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>https:\/\/<\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Investigador l\u00edder<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-11033\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"18885\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/gl\/team\/antonio-gonzalez-martinez-pedrayo\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"18885\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Antonio-Gonzalez.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Antonio-Gonzalez.jpg\" alt=\"Antonio Gonz\u00e1lez Mart\u00ednez-Pedrayo\" width=\"299\" height=\"168\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tAntonio Gonz\u00e1lez Mart\u00ednez-Pedrayo\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>Antonio.Gonzalez.Martinez.Pedrayo@sergas.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-phone\">\n<i class=\"fa fa-phone\"><\/i>\t<a href=\"#0\"  class=\"\" >\n\t\t<span>(+34) 981 950 903<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-website\">\n<i class=\"fa fa-globe\"><\/i>\t<a href=\"http:\/\/orcid.org\/0000-0002-2624-0606\"  class=\"\" target=\"_blank\">\n\t\t<span>http:\/\/orcid.org\/0000-0002-2624-0606<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/gl\/team\/antonio-gonzalez-martinez-pedrayo\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n<br \/>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: INFECTOLOX\u00cdA, INFLAMACI\u00d3N E VACINASObxectivos O obxectivo do noso grupo \u00e9 mellorar o manexo cl\u00ednico dos pacientes con artrite reumatoide utilizando estudos observacionais e experimentais con ferramentas xen\u00e9ticas, de biolox\u00eda [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":12059,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[845],"project_tag":[],"class_list":["post-19220","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-infectologia-gl"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19220","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/comments?post=19220"}],"version-history":[{"count":23,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19220\/revisions"}],"predecessor-version":[{"id":45123,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19220\/revisions\/45123"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media\/12059"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media?parent=19220"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_category?post=19220"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_tag?post=19220"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}