{"id":19221,"date":"2022-01-18T15:12:35","date_gmt":"2022-01-18T14:12:35","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/c027-interacciones-neuroendocrinas-en-enfermedades-reumaticas-e-inflamatorias-neirid\/"},"modified":"2025-07-09T14:33:20","modified_gmt":"2025-07-09T12:33:20","slug":"c027-interacciones-neuroendocrinas-en-enfermedades-reumaticas-e-inflamatorias-neirid","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/gl\/grupo-de-investigacion\/c027-interacciones-neuroendocrinas-en-enfermedades-reumaticas-e-inflamatorias-neirid\/","title":{"rendered":"C027 – Interacci\u00f3ns Neuroendocrinas en Enfermidades Reum\u00e1ticas e Inflamatorias (Neirid)"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.16″ _module_preset=”default” width=”100%” custom_padding=”0px||||false|false” locked=”off” collapsed=”on” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]\u00c1REA: INFLAMACI\u00d3N<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ _module_preset=”default” width=”100%” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/C027-Inv.png” title_text=”C027 Inv” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_toggle title=”Obxectivos e li\u00f1as de investigaci\u00f3n” admin_label=”Obxectivos e li\u00f1as de investigaci\u00f3n” _builder_version=”4.16″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”]<\/p>\n

Obxectivos<\/h3>\n

Dr. Gualillo\u2019s primary research focussed on the immunometabolic molecular signals triggered by adipokines and on the pathways through which these molecules are involved in rheumatic diseases and in the inflammatory response of chondrocytes, synovial cell, and immune cells in particular in osteoarthritis, rheumatoid arthritis and intravertebral disc cells degeneration. Over the past years, his group has contributed to multiple aspects of research on the roles of adipokines in inflammation in rheumatic disorders and to define the molecular basis of immunometabolic responses in chondrocytes, cartilage and intravertebral disc. Dr. Gualillo\u2019s group is also involved in pre-clinical research applications of herbs and natural products in medicine, including studies of herb-drug interactions and other aspects of the safety and pharmacological properties of herbal medicines.
Very recently, the group has focused on the critical importance of biomaterials in the creation of new devices and systems for drug delivery and cell-based regenerative medicine.<\/p>\n

Li\u00f1as de investigaci\u00f3n<\/h3>\n

1- Identification of extracellular and intracellular signaling of novel adipokines in cartilage and other joint tissues
2- Interactions between innate and adaptive immune system and adipose tissue: role of adipokines in the modulation of T regulatory cells and other immune cells subsets
3- Adipokines and intravertebral disc pathophysiology. Effects of adipokines on cartilage relevant trandscription factors
4- Effect of micronutrients of herbal and algae extract on cartilage and disc cells pathophysiology
5- Kinase inhibitors tom target inflammatory response in cartilage<\/p>\n

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[\/et_pb_toggle][et_pb_toggle title=”Equipo investigador” admin_label=”Equipo investigador” _builder_version=”4.21.0″ _module_preset=”default” body_font=”|300|||||||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

L\u00edder<\/strong>
Gualillo, Oreste<\/p>\n

 <\/p>\n\n\n\n
Membros<\/strong>
Abdelhafez, Mariam Ramadan Farrag
Campos Cabaleiro, V\u00edctor
Casado Fern\u00e1ndez, Paula
Dom\u00ednguez Gra\u00f1a, Ant\u00eda
Farrag Zakaria, Yousof
Fern\u00e1ndez Bustillo, Jos\u00e9 Manuel
Fern\u00e1ndez Rodr\u00edguez, Tania
Gallego Goyanes, Adri\u00e1n
Gon\u00e7alvez Fern\u00e1ndez, Carolina
Gonz\u00e1lez Blanco, Laura
Hermida S\u00e1nchez, Miguel
Ortiz Perojo, Paula
Pino M\u00ednguez, Jes\u00fas
Pombo Exp\u00f3sito, Sergio<\/td>\n		Sant\u00edn Amo, Jos\u00e9 Mar\u00eda
Sant\u00edn Mon, Daniel
Serramito Garc\u00eda, Ram\u00f3n
Sineiro Torres, Jorge
Varela Garc\u00eda, Mar\u00eda
V\u00e1zquez Agra, Nerea
Villar Liste, Rosa<\/p>\n

 <\/p>\n

Persoal Colaborador Externo<\/strong>
Cordero Barreal, Alfonso
Lebor\u00e1ns Eiras, Susana
Ruiz Fern\u00e1ndez, Clara<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/et_pb_toggle][et_pb_toggle title=”Proxectos” admin_label=”Proxectos (cambiar s\u00f3 codigo IDIS)” _builder_version=”4.16″ _module_preset=”default” body_font=”|300|||||||” locked=”off” global_colors_info=”{}”]<\/p>\n\n

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