{"id":19229,"date":"2022-01-17T11:23:46","date_gmt":"2022-01-17T10:23:46","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/c021-analisis-clinicos\/"},"modified":"2026-11-04T12:57:39","modified_gmt":"2026-11-04T11:57:39","slug":"c021-analisis-clinicos","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/gl\/grupo-de-investigacion\/c021-analisis-clinicos\/","title":{"rendered":"C021 &#8211; An\u00e1lises Cl\u00ednicos"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;on&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u00c1REA: <a href=\"https:\/\/www.idisantiago.es\/gl\/areas-de-investigacion\/a005-plataformas-y-metodologia\/\">PLATAFORMAS Y METODOLOG\u00cdA<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2021\/11\/grupo_investigacion.jpg&#8221; title_text=&#8221;Corporate portrait of office workers and employees&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Obxectivos e li\u00f1as de investigaci\u00f3n&#8221; admin_label=&#8221;Objetivos y l\u00edneas de investigaci\u00f3n&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Objetivos y l\u00edneas de investigaci\u00f3n<\/h3>\n<ul>\n<li><strong>Diabetes<\/strong>. Procesos de glicaci\u00f3n y complicaciones cr\u00f3nicas. Se estudian distintos mecanismos de glicaci\u00f3n tanto de productos de glicaci\u00f3n avanzada (pentosidina), c\u00f3mo marcadores de glicaci\u00f3n precoz (HbA1c, fructosamina) y su asociaci\u00f3n con las complicaciones micro y macroangiop\u00e1ticas.<br \/>Autoinmunidad. Se identifican p\u00e9ptidos procesados y presentados de forma natural por linfocitos CD8 derivados de la preproinsulina y se estudia la caracterizaci\u00f3n de autoant\u00edgenos en la diabetes de tipo 1. Desarrollo de vacunas. Detecci\u00f3n de nuevos marcadores de riesgo.<br \/>Estudio de marcadores moleculares. Se estudian y dise\u00f1an nuevos marcadores para el diagn\u00f3stico de enfermedades gen\u00e9ticas. Farmacogen\u00f3mica. Se estudian marcadores gen\u00e9ticos y biomoleculares que justifiquen la elevada variabilidad biol\u00f3gica de la HbA1c y la posible detecci\u00f3n de pacientes como altos, medio y bajo glicadores.<\/li>\n<li><strong>Marcadores de riesgo cardiovascular<\/strong>. Se ha desarrollado un estudio de cohorte con 43000 pacientes para el estudio de la Lipoprote\u00edna(a) como factor principal de screening de riesgo cardiovascular, independiente de otros marcadores tradicionales de riesgo.<\/li>\n<li><strong>Lipoprote\u00edna(a) y Angiog\u00e9nesis.<\/strong> Estudio del mecanismo molecular mediante el cual la elevada prevalencia de Lp(a) justificar\u00eda la menor circulaci\u00f3n colateral de la poblaci\u00f3n con niveles elevados de Lp(a) que representa un 25% de la poblaci\u00f3n general. Para ello se esta dise\u00f1ando un array de marcadores de angiog\u00e9nesis y antiangiog\u00e9nesis para estudiar en pacientes con diferentes niveles de Lp(a) y su correlaci\u00f3n angiogr\u00e1fica con el desarrollo de circulaci\u00f3n colateral.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Equipo investigador&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><strong>L\u00edder<\/strong><br \/>Rodr\u00edguez Garc\u00eda, Javier<\/p>\n<p><strong>Membros<\/strong><br \/>Cami\u00f1a Darriba, Manuel F\u00e9lix<br \/>Garc\u00eda Aschauer, Juan Manuel<br \/>Valle Rodr\u00edguez, Andrea<\/p>\n<p><strong>Persoal Colaborador Externo<\/strong><br \/>Rodr\u00edguez-Segade Villamar\u00edn, Santiago<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Proxectos&#8221; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; disabled=&#8221;on&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publicaci\u00f3ns&#8221; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Publicaci\u00f3n 1<\/li>\n<li>Publicaci\u00f3n 2<\/li>\n<li>Etc.<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Web do grupo&#8221; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>https:\/\/<\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Investigador l\u00edder<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; 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border-right-width: 0; } }div, h2, h4,.sptp-member-name-title { font-family: 'Roboto'; } #sptp-7994 .sptp-member-name .sptp-member-name-title{ color:#8A7A0F; } #sptp-7994 .sptp-member-profession .sptp-jop-title{ color:#9EA1B3; font-weight: 200; }<\/style><div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" > <div id=\"sptp-10935\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" > <div class=\"sp-team-pro-page-loading-image\"><\/div> <div class=\"sptp-grid\"> <div class=\"sptp-row \"> <div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\" data-member=\"18895\"> <div class=\"sptp-member border-bg-around-member sptp-bottom-content sptp-square\"> <a class=\"sptp-member-avatar \" href=https:\/\/www.idisantiago.es\/gl\/team\/santiago-rodriguez-segade-villamarin\/ target=_blank > <div class=\"sptp-member-avatar-img-area\" data-id=\"18895\"> <div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image \"> <div class=\"sptp-overflow-h\"> <div class=\"sptp-icon text-center\"> <i class=\"fa fa-plus\"><\/i> <\/div> <img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img \" src=\"https:\/\/www.idisantiago.es\/wp-content\/plugins\/wp-team-pro\/src\/Frontend\/img\/Placeholder-Image.png\" alt=\"Santiago Rodr\u00edguez-Segade Villamar\u00edn\" width=\"600\" height=\"450\"> <\/div> <\/div> <\/div> <\/a> <div class=\"sptp-member-name \"> <h2 class=\"sptp-name\">Santiago Rodr\u00edguez-Segade Villamar\u00edn<\/h2><\/div> <div class=\"sptp-read-more-button\"> <a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/gl\/team\/santiago-rodriguez-segade-villamarin\/\" target=\"_blank\" > + INFO <\/a> <\/div> <\/div> <\/div> <\/div> <\/div> <\/div> <\/div> \n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: PLATAFORMAS Y METODOLOG\u00cdAObjetivos y l\u00edneas de investigaci\u00f3n Diabetes. Procesos de glicaci\u00f3n y complicaciones cr\u00f3nicas. Se estudian distintos mecanismos de glicaci\u00f3n tanto de productos de glicaci\u00f3n avanzada (pentosidina), c\u00f3mo marcadores [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":10312,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[515],"project_tag":[],"class_list":["post-19229","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-investigacion-multidisciplinar-gl"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19229","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/comments?post=19229"}],"version-history":[{"count":2,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19229\/revisions"}],"predecessor-version":[{"id":50999,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19229\/revisions\/50999"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media\/10312"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media?parent=19229"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_category?post=19229"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_tag?post=19229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}