{"id":19251,"date":"2022-01-14T13:27:12","date_gmt":"2022-01-14T12:27:12","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e023-obesidomica\/"},"modified":"2024-10-08T13:26:20","modified_gmt":"2024-10-08T11:26:20","slug":"e023-obesidomica","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/gl\/grupo-de-investigacion\/e023-obesidomica\/","title":{"rendered":"E023 &#8211; Obesid\u00f3mica"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u00c1REA: <a href=\"https:\/\/www.idisantiago.es\/gl\/areas-de-investigacion\/a003-endocrinologia\/\">ENDOCRINOLOX\u00cdA<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/03\/thumbnail_IMG-3224.GrupoMariaPardo.jpg&#8221; title_text=&#8221;thumbnail_IMG-3224.GrupoMariaPardo&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Obxectivos e li\u00f1as de investigaci\u00f3n&#8221; admin_label=&#8221;Objetivos y l\u00edneas de investigaci\u00f3n&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Obxectivos e li\u00f1as de investigaci\u00f3n<\/h3>\n<p>Identification of new communicating signals shed by adipose tissue according to its anatomical localization, and its alteration on the development of obesity pretending as last purpose, to find new biomarkers and therapeutic targets to treat obesity:<\/p>\n<p>&#8211; Proteomics analysis of visceral and subcutaneous adipose tissue secretome and its implication on obesity development<br \/>&#8211; Role of extracellular vesicles released by human adipose tissue in obesity<br \/>&#8211; Functional role and clinical application of exosomal biomarkers released by adipose tissue to the study and monitoring obesity<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Equipo investigador&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<table style=\"width: 100%; border-collapse: collapse; border-style: hidden; height: 250px;\" border=\"0\">\n<tbody>\n<tr style=\"height: 250px;\">\n<td style=\"width: 50%; height: 250px;\"><strong>L\u00edder<\/strong><br \/>Pardo P\u00e9rez, Mar\u00eda<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Membros<\/strong><br \/>Baltar Boileve, Francisco Javier<br \/>Couto Gonz\u00e1lez, Iv\u00e1n<br \/>Est\u00e9vez L\u00f3pez, Adriana<br \/>Lago Baameiro, Nerea<br \/>Santos Benito, Francisco Fernando<br \/>V\u00e1zquez Dur\u00e1n, Jos\u00e9 Adri\u00e1n<\/p>\n<p>&nbsp;<\/p>\n<\/td>\n<td style=\"width: 50%; height: 250px;\">\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Proxectos&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<strong>Functional role and clinical application of exosomal biomarkers released by adipose tissue to the study and monitoring obesity<\/strong><br \/>C\u00f3digo do proxecto: PI19\/00305<br \/>Entidade financiadora: Instituto de Salud Carlos III<br \/>Duraci\u00f3n: 2020-2022<br \/>Cont\u00eda: 99 200 EUR<br \/>Investigador\/a principal: <a href=\"https:\/\/www.idisantiago.es\/gl\/team\/maria-pardo-perez\/\">Mar\u00eda Pardo P\u00e9rez<\/a> <br \/><\/p>\n<p><strong>Papel de las ves\u00edculas extracelulares liberadas por el tejido adiposo humano en la obesidad<\/strong><br \/>C\u00f3digo do proxecto: PI16\/01212<br \/>Entidade financiadora: Instituto de Salud Carlos III<br \/>Duraci\u00f3n: 2017-2019<br \/>Cont\u00eda: 92 565 EUR<br \/>Investigador\/a principal: <a href=\"https:\/\/www.idisantiago.es\/gl\/team\/maria-pardo-perez\/\">Mar\u00eda Pardo P\u00e9rez<\/a> <br \/><\/p>\n<p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publicaci\u00f3ns&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Camino T, Lago-Baameiro N, Bravo SB, Molares-Vila A, Sueiro A, Couto I, Baltar J, Casanueva EF, Pardo M.\u00a0<strong>Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities.<\/strong> <em>Transl Res<\/em>. 2022; 239:85-102.\u00a0 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33465489\/\"><span style=\"color: #808000;\"><strong>doi<span class=\"identifier doi\"><span class=\"id-label\">: <\/span>10.1016\/j.trsl.2021.01.006<\/span><\/strong><\/span><\/a><\/li>\n<li>Camino T, Lago-Baameiro N, Bravo SB, Sueiro A, Couto I, Santos F, Baltar J, Casanueva FF, Pardo M. <strong>Vesicles Shed by Pathological Murine Adipocytes Spread Pathology: Characterization and Functional Role of Insulin Resistant\/Hypertrophied Adiposomes.<\/strong> <em>Int J Mol Sci<\/em>. 2020;21(6):2252.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32214011\/\"><span style=\"color: #808000;\"><strong> doi<span class=\"identifier doi\"><span class=\"id-label\">: 10.3390\/ijms21062252<\/span><\/span><\/strong><\/span><\/a><\/li>\n<li>Camino T, Lago-Baameiro N, Martis-Sueiro A, Couto I, Santos F, Baltar J, Pardo M. <strong>Deciphering Adipose Tissue Extracellular Vesicles Protein Cargo and Its Role in Obesity.<\/strong> <em>Int J Mol Sci<\/em>. 2020;21(24):9366.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33316953\/\"><span style=\"color: #808000;\"><strong> doi<span class=\"identifier doi\"><span class=\"id-label\">: 10.3390\/ijms21249366<\/span><\/span><\/strong><\/span><\/a><\/li>\n<li>P\u00e9rez-Sotelo D, Roca-Rivada A, Baamonde I, Baltar J, Castro AI, Dom\u00ednguez E, Collado M, Casanueva FF, Pardo M.. <strong>Lack of Adipocyte-Fndc5\/Irisin Expression and Secretion Reduces Thermogenesis and Enhances Adipogenesis.<\/strong> <em>Sci Rep<\/em>. 2017 Nov 24;7(1):16289.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29176631\/\"><span style=\"color: #808000;\"><strong> doi<span class=\"identifier doi\"><span class=\"id-label\">: 10.1038\/s41598-017-16602-z<\/span><\/span><\/strong><\/span><\/a><\/li>\n<li>S\u00e1nchez-Herrero E, Campos-Silva C, C\u00e1ceres-Martell Y, Robado de Lope L, Sanz-Moreno S, Serna-Blasco S, Rodr\u00edguez-Festa A, Ares Trotta D, Mart\u00edn-Acosta P, Pati\u00f1o C, Coronado MJ, Beneitez A, Jara R, Lago-Baameiro N, Camino T, Cruz-Berm\u00fadez A, PARDO M, Gonz\u00e1lez-Rumayor V, Val\u00e9s-G\u00f3mez M, Provencio M, Romero A. Towards EV-based non-invasive testing. S\u00e1nchez-Herrero et al. <strong>ALK fusion transcripts can be detected in extracellular vesicles (EVs) from non-small cell lung cancer cell lines and patient plasma.<\/strong> <em>Clin Chemistry<\/em>.2022 Jan 12.<\/li>\n<li>de Frutos S, Griera M, Hatem-Vaquero M, Campillo S, Guti\u00e9rrez-Calabres E, Garc\u00eda-Ayuso D, Pardo M, Calleros L, Rodr\u00edguez-Puyol M, Rodr\u00edguez-Puyol D. <strong>The integrin beta1 modulator Tirofiban prevents adipogenesis and obesity by the overexpression of integrin-linked kinase: a pre-clinical approach in vitro and in vivo.<\/strong> <em>Cell Biosci<\/em>. 2022;12(1):10.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35090553\/\"><span style=\"color: #808000;\"><strong> doi<span class=\"identifier doi\"><span class=\"id-label\">: 10.1186\/s13578-022-00746-1<\/span><\/span><\/strong><\/span><\/a><\/li>\n<li>Barrachina MN, Hermida-Nogueira L, Moran LA, Casas V, Hicks SM, Sueiro AM, Di Y, Andrews RK, Watson SP, Gardiner EE, Abian J, Carrascal M, Pardo M, Garc\u00eda \u00c1. <strong>Phosphoproteomic Analysis of Platelets in Severe Obesity Uncovers Platelet Reactivity and Signaling Pathways Alterations.<\/strong> <em>Arterioscler Thromb Vasc Biol<\/em>. 2021 Jan;41(1):478-490.<span style=\"color: #808000;\"><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33147989\/\"> doi<\/a><span class=\"identifier doi\"><span class=\"id-label\">: 10.1161\/ATVBAHA.120.314485<br \/><\/span><\/span><\/strong><\/span><\/li>\n<li>Barrachina MN, Sueiro AM, Casas V, Izquierdo I, Hermida-Nogueira L, Guiti\u00e1n E, Casanueva FF, Abi\u00e1n J, Carrascal M, Pardo M, Garc\u00eda \u00c1. <strong>A combination of proteomic approaches defines a biomarker panel of extracellular vesicles of obese patients related to the risk of suffering cardiovascular disease.<\/strong> <em>Proteomics<\/em>. 2019; 19(1-2): e1800248.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30536591\/\"><span style=\"color: #808000;\"><strong> doi<span class=\"identifier doi\"><span class=\"id-label\">: 10.1002\/pmic.201800248<\/span><\/span><\/strong><\/span><\/a><\/li>\n<li>Barrachina MN, Sueiro AM, Izquierdo I, Hermida-Nogueira L, Guiti\u00e1n E, Casanueva FF, Farndale RW, Moroi M, Jung SM, Pardo M, Garc\u00eda \u00c1. <strong>GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: Elucidating potential anti-atherothrombotic targets in obesity.<\/strong> <em>Atherosclerosis<\/em>.2019 Feb; 281:62-70.<span style=\"color: #808000;\"><strong>\u00a0<span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30658193\/\">doi<span class=\"identifier doi\"><span class=\"id-label\">: 10.1016\/j.atherosclerosis.2018.12.023<\/span><\/span><\/a><\/span><\/strong><\/span><\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Web do grupo&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><a href=\"https:\/\/obesidomica.wixsite.com\/grupoobesidomica\/quienes-somos\">https:\/\/obesidomica.wixsite.com\/grupoobesidomica\/quienes-somos<\/a><\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Investigadora l\u00edder<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-10683\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"18925\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/gl\/team\/maria-pardo-perez\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"18925\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/03\/thumbnail_IMG_2670.MariaPardo-320x320.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/03\/thumbnail_IMG_2670.MariaPardo-320x320.jpg\" alt=\"Mar\u00eda Pardo P\u00e9rez\" width=\"320\" height=\"320\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tMar\u00eda Pardo P\u00e9rez\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>maria.pardo.perez@sergas.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-phone\">\n<i class=\"fa fa-phone\"><\/i>\t<a href=\"#0\"  class=\"\" >\n\t\t<span>(+34) 981 955 071<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-website\">\n<i class=\"fa fa-globe\"><\/i>\t<a href=\"https:\/\/orcid.org\/0000-0002-9967-1650\"  class=\"\" target=\"_blank\">\n\t\t<span>https:\/\/orcid.org\/0000-0002-9967-1650<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/gl\/team\/maria-pardo-perez\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: ENDOCRINOLOX\u00cdAObxectivos e li\u00f1as de investigaci\u00f3n Identification of new communicating signals shed by adipose tissue according to its anatomical localization, and its alteration on the development of obesity pretending as [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":19697,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[505],"project_tag":[652,653,654],"class_list":["post-19251","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-endocrinologia-gl","project_tag-obesidad-gl","project_tag-adiposo-gl","project_tag-endocrino-gl"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/comments?post=19251"}],"version-history":[{"count":14,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19251\/revisions"}],"predecessor-version":[{"id":36606,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19251\/revisions\/36606"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media\/19697"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media?parent=19251"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_category?post=19251"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_tag?post=19251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}