{"id":19259,"date":"2022-01-14T12:21:36","date_gmt":"2022-01-14T11:21:36","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e036-celulas-madre-y-enfermedades-humanas\/"},"modified":"2025-06-17T09:04:23","modified_gmt":"2025-06-17T07:04:23","slug":"e036-celulas-madre-y-enfermedades-humanas","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/gl\/grupo-de-investigacion\/e036-celulas-madre-y-enfermedades-humanas\/","title":{"rendered":"E036 &#8211; C\u00e9lulas Nai e Enfermidades Humanas"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u00c1REA: \u00a0<a href=\"https:\/\/www.idisantiago.es\/gl\/areas-de-investigacion\/a002-genetica-y-biologia-de-sistemas\/\">XEN\u00c9TICA E BIOLOX\u00cdA DE SISTEMAS<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/01\/Grupo-E036.jpg&#8221; title_text=&#8221;Grupo E036&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Obxectivos e li\u00f1as de investigaci\u00f3n&#8221; admin_label=&#8221;Obxectivos e li\u00f1as de investigaci\u00f3n&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Obxectivos<\/h3>\n<p>O grupo de C\u00e9lulas Nai e Enfermidades Humanas ten o obxectivo principal de contribu\u00edr a unha mellor comprensi\u00f3n do impacto da regulaci\u00f3n epixen\u00e9tica no control transcricional do xenoma de mam\u00edferos que goberna as decisi\u00f3ns sobre o destino das c\u00e9lulas durante o desenvolvemento embrionario e as enfermidades humanas. A nosa meta m\u00e1is ambiciosa \u00e9 desenvolver novidosas estratexias terap\u00e9uticas para os trastornos relacionados coa idade, obesidade e as enfermidades raras. Para iso, utilizamos unha ampla variedade de m\u00e9todos en biolox\u00eda molecular, enfoques xen\u00f3micos e prote\u00f3micos, edici\u00f3n do xenoma e an\u00e1lises bioinform\u00e1ticas.<\/p>\n<h3>Li\u00f1as de investigaci\u00f3n<\/h3>\n<p>As principais li\u00f1as de investigaci\u00f3n en marcha do grupo son:<br \/>1) Modelizaci\u00f3n de enfermidades mediante tecnolox\u00eda iPSC<br \/>2) Descubrimento de programas moleculares envoltos en reprogramaci\u00f3n celular e pluripotencia<br \/>3) Impacto do envellecemento e obesidade en mecanismos epixen\u00e9ticos<br \/>4) Novas estratexias de rexuvenecemento celular<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Equipo investigador&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<table style=\"width: 100%; border-collapse: collapse; border-style: hidden; height: 124px;\" border=\"0\">\n<tbody>\n<tr style=\"height: 124px;\">\n<td style=\"width: 50%; height: 124px;\">\n<p><strong>L\u00edder<\/strong><br \/>Fidalgo P\u00e9rez, Miguel \u00c1ngel<\/p>\n<p><strong>Membros<\/strong><br \/>Ameneiro Qui\u00f1oy, Cristina<br \/>Escudero P\u00e9rez, Adriana<br \/>Fuentes Iglesias, Alejandro<br \/>Garc\u00eda Outeiral, Vera<br \/>Pardavila Paz, Jos\u00e9 \u00c1ngel<\/p>\n<\/td>\n<td style=\"width: 50%; height: 124px;\">\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Proxectos&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publicaci\u00f3ns&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Fuentes-Iglesias A, Ameneiro C, Guallar D, Fidalgo M. <strong>Detecting and Modulating ER Stress to Improve Generation of Induced Pluripotent Stem Cells<\/strong>. <em>Methods Mol Biol.<\/em> 2021 Mar 11;.<span style=\"color: #808000;\"><strong> <a style=\"color: #808000;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33689163\/\">doi: 10.1007\/7651_2021_354<\/a><\/strong><\/span><\/li>\n<li>Guallar D, Fuentes-Iglesias A, Souto Y, Ameneiro C, Freire-Agulleiro O, Pardavila JA, Escudero A, Garcia-Outeiral V, Moreira T, Saenz C, Xiong H, Liu D, Xiao S, Hou Y, Wu K, Torrecilla D, Hartner JC, Blanco MG, Lee LJ, L\u00f3pez M, Walkley CR, Wang J, Fidalgo M. <strong>ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress<\/strong>. <em>Cell Stem Cell.<\/em> 2020 Aug 6;27(2):300-314.e11. <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.stem.2020.04.016\">doi: 10.1016\/j.stem.2020.04.016<\/a><\/strong><\/span><\/li>\n<li>Ameneiro C, Moreira T, Fuentes-Iglesias A, Coego A, Garcia-Outeiral V, Escudero A, Torrecilla D, Mulero-Navarro S, Carvajal-Gonzalez JM, Guallar D, Fidalgo M.<strong> BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells<\/strong>. <em>Life Sci Alliance<\/em>. 2020 May;3(5). <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"http:\/\/doi.org\/10.26508\/lsa.201900534\">doi: 10.26508\/lsa.201900534<\/a><\/strong><\/span><\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Web do grupo&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>https:\/\/www.fidalgostemlab.com\/<\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Investigador l\u00edder<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-10591\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"18936\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/gl\/team\/miguel-angel-fidalgo-perez\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"18936\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/01\/Miguel-Fidalgo-320x320.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/01\/Miguel-Fidalgo-320x320.jpg\" alt=\"Miguel \u00c1ngel Fidalgo P\u00e9rez\" width=\"320\" height=\"320\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tMiguel \u00c1ngel Fidalgo P\u00e9rez\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>miguel.fidalgo@usc.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-phone\">\n<i class=\"fa fa-phone\"><\/i>\t<a href=\"#0\"  class=\"\" >\n\t\t<span>(+34) 881 815 385<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-website\">\n<i class=\"fa fa-globe\"><\/i>\t<a href=\"http:\/\/orcid.org\/0000-0003-1134-2674\"  class=\"\" target=\"_blank\">\n\t\t<span>http:\/\/orcid.org\/0000-0003-1134-2674<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/gl\/team\/miguel-angel-fidalgo-perez\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: \u00a0XEN\u00c9TICA E BIOLOX\u00cdA DE SISTEMASObxectivos O grupo de C\u00e9lulas Nai e Enfermidades Humanas ten o obxectivo principal de contribu\u00edr a unha mellor comprensi\u00f3n do impacto da regulaci\u00f3n epixen\u00e9tica no [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":11434,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[507],"project_tag":[],"class_list":["post-19259","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-genetica-y-biologia-de-sistemas-gl"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/comments?post=19259"}],"version-history":[{"count":11,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19259\/revisions"}],"predecessor-version":[{"id":40707,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19259\/revisions\/40707"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media\/11434"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media?parent=19259"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_category?post=19259"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_tag?post=19259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}