{"id":19269,"date":"2022-01-14T11:25:13","date_gmt":"2022-01-14T10:25:13","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e033-virus-y-cancer\/"},"modified":"2026-03-05T09:03:43","modified_gmt":"2026-03-05T08:03:43","slug":"e033-virus-y-cancer","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/gl\/grupo-de-investigacion\/e033-virus-y-cancer\/","title":{"rendered":"E033 &#8211; Virus e cancro"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u00c1REA: <a href=\"https:\/\/www.idisantiago.es\/gl\/areas-de-investigacion\/a001-oncoloxia\/\">ONCOLOX\u00cdA<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Grupo-E033-scaled.jpg&#8221; title_text=&#8221;Grupo E033&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Obxectivos e li\u00f1as de investigaci\u00f3n&#8221; admin_label=&#8221;Obxectivos e li\u00f1as de investigaci\u00f3n&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Obxectivos<\/h3>\n<p>Temos d\u00faas li\u00f1as de investigaci\u00f3n fundamentais: (i) a explotaci\u00f3n da maquinaria celular por parte dos virus co fin de mellorar a s\u00faa replicaci\u00f3n; (ii) as v\u00edas moleculares celulares implicadas no control da realizaci\u00f3n viral. Estamos especialmente interesados no papel que as prote\u00ednas tipo ubiquitina xogan en ambos procesos.<\/p>\n<h3>Li\u00f1as de investigaci\u00f3n<\/h3>\n<ul>\n<li>Identificaci\u00f3n dos mecanismos de patoxenicidade viral inclu\u00edndo aqueles que conducen \u00e1 transformaci\u00f3n oncox\u00e9nica.<\/li>\n<li>Estudo das v\u00edas moleculares celulares implicadas no control do ciclo celular, a proliferaci\u00f3n celular, a transformaci\u00f3n oncox\u00e9nica e o control antiviral.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Equipo investigador&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<table style=\"width: 100%; border-collapse: collapse; border-style: hidden;\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\"><strong>L\u00edder<\/strong><br \/>Rivas V\u00e1zquez, Mar\u00eda del Carmen<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Membros<\/strong><br \/>Blanquer G\u00e1rate, Mar\u00eda<br \/>Herrera Gavil\u00e1n, Jos\u00e9 Antonio<br \/>P\u00e9rez P\u00e9rez, Montse<br \/>Rodr\u00edguez Lemus, Beatriz<\/p>\n<\/td>\n<td style=\"width: 50%;\">\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Proxectos&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publicaci\u00f3ns&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>AE Motiam, CF de la Cruz-Herrera, S Vidal, et al, C Rivas (12\/12) (AC).<strong> SUMOylation modulates the stability and function of PI3K- p110 beta<\/strong>. <em>Cellular and Molecular Life Sciences<\/em> 2021, 78(8):4053-4065. <strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1007\/s00018-021-03826-6\">doi: 10.1007\/s00018-021-03826-6<\/a><\/span><\/strong><\/li>\n<li>S Vidal, M S\u00e1nchez-Aparicio, R Seoane, et al, C Rivas (12\/12) (AC). <strong>Cellular expression of Ebola virus VP24 protein compromises the integrity of the nuclear envelope and induces a laminopathy-like cellular phenotype<\/strong>. <em>Mbio<\/em> 2021, 12(4): e0097221 <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1128\/mBio.00972-21\">doi: 10.1128\/mBio.00972-21<\/a><\/strong><\/span><\/li>\n<li>S Vidal, YH Bouzaher, AE Motiam, R Seoane, C Rivas. (5\/5) (AC). <strong>Overview of the regulation of the class IA PI3K\/AKT pathway by SUMO<\/strong>. <em>Seminars in Cell &amp; Developmental Biology.<\/em> 2021, S1084-9521(21)00275-5<\/li>\n<li>C Rivas. (1\/1) (AC) Editorial: <strong>SUMO proteins in host defense<\/strong>. <em>Frontiers in Cell and Developmental Biology<\/em>. 2021 <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.3389\/fcell.2021.789877\">https:\/\/doi.org\/10.3389\/fcell.2021.789877<\/a><\/strong><\/span><\/li>\n<li>R Seoane, S Vidal, YH Bouzaher, A E Motiam and C Rivas. (5\/5) (AC). <strong>The Interaction of Viruses with the Cellular Senescence Response.<\/strong> <em>Biology<\/em> 2020, 9(12):455. <a href=\"https:\/\/doi.org\/10.3390\/biology9120455\"><span style=\"color: #808000;\"><strong>doi: 10.3390\/biology9120455<\/strong><\/span><\/a><\/li>\n<li>AE Motiam, S Vidal, R Seoane, YH Bouzaher, J Gonz\u00e1lez-Santamar\u00eda, and C Rivas. (6\/6) (AC) <strong>SUMO and cytoplasmic RNA viruses: from enemies to best friends.<\/strong> In: R Barrio, J Sutherland, M Rodr\u00edguez (eds) Proteostasis and Disease. <em>Advances in Experimental Medicine and Biology<\/em>. 2020, vol 1233. Springer, Cham. <strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1007\/978-3-030-38266-7_11\">https:\/\/doi.org\/10.1007\/978-3-030-38266-7_11<\/a><\/span><\/strong>, Online ISBN: 978-3-030-38266-7<\/li>\n<li>S Vidal, AE Motiam, R Seoane, et al, C Rivas (15\/15) (AC). <strong>Regulation of the Ebola Virus VP24 protein by SUMO<\/strong>. <em>Journal of Virology<\/em>. 2019, 94(1):e01687-19 <a href=\"https:\/\/doi.org\/10.1128\/JVI.01687-19\"><span style=\"color: #808000;\"><strong>doi:10.1128\/JVI.01687-19<\/strong><\/span><\/a><\/li>\n<li>AE Motiam, S Vidal, CF de la Cruz-Herrera, et al, C Rivas (14\/14) (AC).<strong> Interplay between SUMOylation and NEDDylation regulates RPL11 localization and function<\/strong> <em>The Faseb Journal,<\/em> 2018, 33: 643-651. <a href=\"https:\/\/doi.org\/10.1096\/fj.201800341rr\"><span style=\"color: #808000;\"><strong>doi: 10.1096\/fj.201800341RR<\/strong><\/span><\/a><\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Web do grupo&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><a href=\"https:\/\/www.usc.es\/cimus\/es\/investigacion\/grupos-de-investigacion\/virus-and-cancer\">https:\/\/www.usc.es\/cimus\/es\/investigacion\/grupos-de-investigacion\/virus-and-cancer<\/a><\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Investigadora l\u00edder<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-10494\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"18945\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/gl\/team\/maria-del-carmen-rivas-vazquez\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"18945\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Carmen-Rivas-320x320.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Carmen-Rivas-320x320.jpg\" alt=\"Mar\u00eda del Carmen Rivas V\u00e1zquez\" width=\"320\" height=\"320\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tMar\u00eda del Carmen Rivas V\u00e1zquez\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>mcarmen.rivas@usc.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-phone\">\n<i class=\"fa fa-phone\"><\/i>\t<a href=\"#0\"  class=\"\" >\n\t\t<span>(+34) 881 815 485<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-website\">\n<i class=\"fa fa-globe\"><\/i>\t<a href=\"https:\/\/orcid.org\/0000-0002-0518-7199\"  class=\"\" target=\"_blank\">\n\t\t<span>https:\/\/orcid.org\/0000-0002-0518-7199<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/gl\/team\/maria-del-carmen-rivas-vazquez\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: ONCOLOX\u00cdAObxectivos Temos d\u00faas li\u00f1as de investigaci\u00f3n fundamentais: (i) a explotaci\u00f3n da maquinaria celular por parte dos virus co fin de mellorar a s\u00faa replicaci\u00f3n; (ii) as v\u00edas moleculares celulares [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":12095,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[513],"project_tag":[],"class_list":["post-19269","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-oncologia-gl"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19269","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/comments?post=19269"}],"version-history":[{"count":13,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19269\/revisions"}],"predecessor-version":[{"id":45472,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19269\/revisions\/45472"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media\/12095"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media?parent=19269"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_category?post=19269"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_tag?post=19269"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}