{"id":19273,"date":"2022-01-14T11:01:27","date_gmt":"2022-01-14T10:01:27","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e018-ciclo-celular-y-oncologia-ciclon\/"},"modified":"2025-07-02T11:08:21","modified_gmt":"2025-07-02T09:08:21","slug":"e018-ciclo-celular-y-oncologia-ciclon","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/gl\/grupo-de-investigacion\/e018-ciclo-celular-y-oncologia-ciclon\/","title":{"rendered":"E018 &#8211; Ciclo Celular e Oncolox\u00eda (CiClOn)"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u00c1REA: <a href=\"https:\/\/www.idisantiago.es\/gl\/areas-de-investigacion\/a001-oncoloxia\/\">ONCOLOX\u00cdA<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Grupo-E018-CYCLON.jpg&#8221; title_text=&#8221;Grupo E018 CYCLON&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Obxectivos e li\u00f1as de investigaci\u00f3n&#8221; admin_label=&#8221;Objetivos y l\u00edneas de investigaci\u00f3n&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Objetivos<\/h3>\n<p>A major goal of the group has been to study the roles of cell cycle inhibitors in cell cycle regulation and tumorigenesis. <br \/>In recent years, the group has focused in exploring new therapeutic strategies for cancer.<\/p>\n<h3>L\u00edneas de investigaci\u00f3n<\/h3>\n<ul>\n<li>Evaluation of nanomaterials as new therapeutic strategies in cancer.<\/li>\n<li>Development of refined animal models of advanced cancer.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Equipo investigador&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<table style=\"width: 100%; border-collapse: collapse; border-style: hidden;\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\"><strong>L\u00edder<\/strong><br \/>Vidal Figueroa, Anxo<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Membros<\/strong><br \/>Montenegro Garc\u00eda, Javier<br \/>Prieto Soler, Sandra Yaneth<br \/>Tob\u00edo Ageitos, Araceli<br \/>Turrero Braojos, \u00c1ngela<br \/>Sartages Garc\u00eda, Miriam<\/p>\n<\/td>\n<td style=\"width: 50%;\">\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Proxectos&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publicaci\u00f3ns&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Vilas JM, Carneiro C, Da Silva-Alvarez S, Ferreiros A, Gonzalez P, Gomez M, Ortega S, Serrano M, Garcia-Caballero T, Gonzalez-Barcia M, Vidal A*, Collado M*. A<strong>dult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging<\/strong>. <em>Aging Cell<\/em> 17(5): e12834 (2018). <a href=\"https:\/\/doi.org\/10.1111\/acel.12834\"><span style=\"color: #808000;\"><strong>doi: 10.1111\/acel.12834<\/strong><\/span><\/a><\/li>\n<li>Ferreiros A, Pedrosa P, Da Silva-Alvarez S Triana-Martinez F, Vilas JM, Gonzalez P, Gomez M, Li H, Garcia-Caballero T, Gonzalez-Barcia M, Vidal A*, Collado M*. <strong>Context-dependent impact of RAS oncogene expression on cellular reprogramming to pluripotency<\/strong>. <em>Stem Cell Reports<\/em>. 12(5):1099-1112 (2019). <span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.stemcr.2015.02.007\">doi: 10.1016\/j.stemcr.2019.04.006IF<\/a><\/strong><\/span><\/li>\n<li>Triana-Mart\u00ednez F, Picallos-Rabina P, Da Silva-\u00c1lvarez S, Pietrocola F, Llanos S, Rodilla V, Soprano E, Pedrosa P, Ferreir\u00f3s A, Barradas M, Hern\u00e1ndez-Gonz\u00e1lez F, Lalinde M, Prats N, Bernad\u00f3 C, Gonz\u00e1lez P, G\u00f3mez M, Ikonomopoulou MP, Fern\u00e1ndez-Marcos PJ, Garc\u00eda-Caballero T, Del Pino P, Arribas J, Vidal A, Gonz\u00e1lez-Barcia M, Serrano M, Loza MI, Dom\u00ednguez E, Collado M. <strong>Identification and characterization of Cardiac Glycosides as senolytic compounds.<\/strong> <em>Nat Commun<\/em>. 2019 Oct 21;10(1):4731. <strong><span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1038\/s41467-019-12888-x\">doi: 10.1038\/s41467-019-12888-x<\/a><\/span><\/strong><\/li>\n<li>Ledo, A.M., Senra, A., Rilo-Alvarez, H., Borrajo, E., Vidal, A., Alonso, M.J., Garcia-Fuentes, M. <strong>mRNA-activated matrices encoding transcription factors as primers of cell differentiation in tissue engineering.<\/strong> <em>Biomaterials<\/em>. 2020 Jul; 247:120016.<a href=\"https:\/\/doi.org\/10.1016\/j.biomaterials.2020.120016\"> <span style=\"color: #808000;\"><strong>doi: 10.1016\/j.biomaterials.2020.120016<\/strong><\/span><\/a><\/li>\n<li>El Motiam A; de la Cruz-Herrera CF; Vidal S; Seoane R; Baz-Mart\u00ednez M; Bouzaher YH; Lecona E; Esteban M; Rodr\u00edguez MS; Vidal A; Collado M; Rivas C. SUMOylation modulates the stability and function of PI3K-p110\u03b2. Cellular and Molecular Life Sciences, 2021, 78(8): 4053-4065.<span style=\"color: #808000;\"><strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1007\/s00018-021-03826-6\"> doi: 10.1007\/s00018-021-03826-6<\/a><\/strong><\/span><\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Web do grupo&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><a href=\"https:\/\/cimus.usc.gal\/group\/cell-cycle-and-oncology\">https:\/\/cimus.usc.gal\/group\/cell-cycle-and-oncology<\/a><\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Investigador l\u00edder<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-10467\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"18948\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/gl\/team\/anxo-vidal-figueroa\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"18948\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Anxo-Vidal_hall-320x320.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2022\/02\/Anxo-Vidal_hall-320x320.jpg\" alt=\"Anxo Vidal Figueroa\" width=\"320\" height=\"320\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tAnxo Vidal Figueroa\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>anxo.vidal@usc.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-phone\">\n<i class=\"fa fa-phone\"><\/i>\t<a href=\"#0\"  class=\"\" >\n\t\t<span>(+34) 881 815 417<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/gl\/team\/anxo-vidal-figueroa\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: ONCOLOX\u00cdAObjetivos A major goal of the group has been to study the roles of cell cycle inhibitors in cell cycle regulation and tumorigenesis. In recent years, the group has [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":12519,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[513],"project_tag":[647,658,659],"class_list":["post-19273","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-oncologia-gl","project_tag-celular-gl","project_tag-oncologia-gl","project_tag-ciclo-gl"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19273","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/comments?post=19273"}],"version-history":[{"count":8,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19273\/revisions"}],"predecessor-version":[{"id":41070,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19273\/revisions\/41070"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media\/12519"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media?parent=19273"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_category?post=19273"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_tag?post=19273"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}