{"id":19284,"date":"2021-09-22T14:55:06","date_gmt":"2021-09-22T12:55:06","guid":{"rendered":"https:\/\/www.idisantiago.es\/grupo-de-investigacion\/e044-unidad-de-nano-oncologia-y-terapeutica-traslacional\/"},"modified":"2026-09-08T11:22:58","modified_gmt":"2026-09-08T09:22:58","slug":"e044-unidad-de-nano-oncologia-y-terapeutica-traslacional","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/gl\/grupo-de-investigacion\/e044-unidad-de-nano-oncologia-y-terapeutica-traslacional\/","title":{"rendered":"E044 – Unidade de nano-oncolox\u00eda e terap\u00e9utica traslacional"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||||false|false” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.16″ _module_preset=”default” width=”100%” custom_padding=”0px||||false|false” locked=”off” collapsed=”on” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]\u00c1REA: ONCOLOX\u00cdA<\/a>
\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ _module_preset=”default” width=”100%” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.idisantiago.es\/wp-content\/uploads\/2020\/03\/E044-unidade-nano-oncoloxia-terapeutica-traslacional.jpg” title_text=”E044-unidade-nano-oncoloxia-terapeutica-traslacional” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_toggle title=”Obxectivos e li\u00f1as de investigaci\u00f3n” admin_label=”Obxectivos e li\u00f1as de investigaci\u00f3n” _builder_version=”4.16″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”]<\/p>\n

Obxectivos<\/h3>\n

O obxectivo principal desta unidade \u00e9 explorar estratexias innovadoras, baseadas na aplicaci\u00f3n da nanotecnolox\u00eda, para desenvolver terapias m\u00e1is eficientes e seguras, e novas ferramentas para diagn\u00f3stico avanzado da enfermidade.<\/p>\n

A nanotecnolox\u00eda ofrece numerosas vantaxes para desenvolver terapias m\u00e1is eficientes e seguras. Na nosa unidade, desenvolvemos nanopart\u00edculas capaces de actuar como transportadores de f\u00e1rmacos, para lograr unha acumulaci\u00f3n selectiva en tumor e met\u00e1stase, aumentando a s\u00faa eficacia e diminu\u00edndo os efectos adversos relacionados cunha distribuci\u00f3n indiscriminada polo organismo.<\/p>\n

Gran parte da nosa actividade c\u00e9ntrase no desenvolvemento de terapias dirixidas baseadas en biomol\u00e9culas como son prote\u00ednas, \u00e1cidos nucleicos, p\u00e9ptidos, ou apt\u00e1meros. As nosas nanopart\u00edculas son sistemas seguros, biocompatibles e biodegradables, capaces de protexer a este tipo de biomol\u00e9culas fronte a procesos de degradaci\u00f3n, favorecer o seu paso a trav\u00e9s de barreiras biol\u00f3xicas, e o seu acceso \u00f3 lugar de acci\u00f3n, en definitiva favorecendo a s\u00faa traslaci\u00f3n \u00e1 cl\u00ednica.<\/p>\n

Exploramos adem\u00e1is a oportunidade de aplicalas no desenvolvemento de novas ferramentas de diagn\u00f3stico empregndo t\u00e9cnicas de imaxe molecular.<\/p>\n

Li\u00f1as de investigaci\u00f3n<\/h3>\n

O obxectivo principal da Unidade de Nano-Oncolox\u00eda \u00e9 explorar estratexias innovadoras, baseadas na aplicaci\u00f3n da nanotecnolox\u00eda, para desenvolver terapias m\u00e1is eficientes e seguras, e novas ferramentas para diagn\u00f3stico avanzado da enfermidade.O enfermo est\u00e1 no centro da nosa investigaci\u00f3n, e temos en conta, desde fases moi temper\u00e1s o desenvolvemento, cales son os puntos cr\u00edticos para que a nosa tecnolox\u00eda poida chegar \u00e1 cl\u00ednica.<\/p>\n

A nosa actividade p\u00f3dese resumir nos seguintes puntos:<\/p>\n

    \n
  • Dese\u00f1o e avaliaci\u00f3n de novas nanoterapias e nanoinmunoterapias para lograr tratamentos m\u00e1is efectivos e seguros, e interferir coa formaci\u00f3n de met\u00e1stase e progresi\u00f3n da enfermidade.<\/li>\n
  • Desenvolvemento de novas ferramentas de diagn\u00f3stico para imaxe molecular baseadas en nanotecnolox\u00eda. O obxectivo \u00e9 conseguir diagnosticar a presenza de pequenas agrupaci\u00f3ns de c\u00e9lulas tumorais que dar\u00e1n orixe \u00e1 formaci\u00f3n de met\u00e1stase.<\/li>\n
  • Aplicaci\u00f3n da nosa tecnolox\u00eda noutras \u00e1reas de co\u00f1ecemento. Como a nanomedicina \u00e9 unha ciencia transversal, a nosa tecnolox\u00eda \u00e9 adem\u00e1is de potencial aplicaci\u00f3n para outras enfermidades, e por iso tamb\u00e9n estamos abertos a contribu\u00edr a outros \u00e1mbitos da medicina, como por exemplo a busca de novos tratamentos para enfermidades raras, a medicina rexenerativa, ou a microbiolox\u00eda.<\/li>\n<\/ul>\n

    [\/et_pb_toggle][et_pb_toggle title=”Equipo investigador” admin_label=”Equipo investigador” _builder_version=”4.21.0″ _module_preset=”default” body_font=”|300|||||||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

    L\u00edder<\/strong>
    Fuente Freire, Mar\u00eda de la<\/p>\n

    Col\u00edder<\/strong>
    Garc\u00eda Fern\u00e1ndez, J\u00e9nifer<\/p>\n

    Membros<\/strong>
    Cascallar Castro, Mar\u00eda
    Diego Gonz\u00e1lez, Lara
    Escobar Garc\u00eda-Caro, M\u00f3nica
    Font\u00e1n Luis, Iria
    Groba de Antas, Soraya
    Iglesias Baleato, Mar\u00eda
    L\u00f3pez L\u00f3pez, Alice Montserrat
    Ramos Docampo, Mar\u00eda Emma
    Rivadulla Costa, Laura
    V\u00e1zquez R\u00edos, Abi Judith<\/p>\n

    Persoal Colaborador Externo<\/strong>
    Dom\u00ednguez, B\u00e1rbara
    Fazal, Sajid
    Fern\u00e1ndez G\u00f3mez, Elsa
    Garrastazu Pereira, Gabriela
    Touza Otero, Lara<\/p>\n

    [\/et_pb_toggle][et_pb_toggle title=”Proxectos” admin_label=”Proyectos” _builder_version=”4.16″ _module_preset=”default” body_font=”|300|||||||” locked=”on” global_colors_info=”{}”]
    \n[\/et_pb_toggle][et_pb_toggle title=”Publicaci\u00f3ns” admin_label=”Publicaciones” _builder_version=”4.16″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”] <\/p>\n

      \n
    • Alonso-Nocelo M, Abellan-Pose R, Vidal A, Abal M, Csaba N, Alonso MJ, Lopez-Lopez R, de la Fuente M*. Selective interaction of PEGylated Polyglutamic Acid nanocapsules with cancer cells in a 3D model of a metastatic lymph node. Journal of Nanobiotechnology, 14:51-, 2016. DOI: 10.1186\/s12951-016-0207-8.<\/li>\n
    • Reimondez-Troiti\u00f1o S, Alcalde I, Csaba N, I\u00f1igo-Portugu\u00e9s A, de la Fuente M, Bech F, Riestra AC, Merayo-Lloves, Alonso MJ. Polymeric nanocapsules: a potential new therapy for corneal wound healing. Drug Delivery and Translational Research, 6 (6): 708-721, 2016. doi:10.1007\/s13346-016-0312-0.<\/li>\n
    • Nieto D, McGlynn P, de la Fuente M, Lopez-Lopez R, O\u2019connor GM. Laser microfabrication of a microheater chip for cell culture outside a cell incubator. Colloids and Surfaces B: Biointerfaces Biointerfaces, 154: 263-269 (2017). DOI:\u00a010.1016\/j.colsurfb.2017.03.043<\/li>\n
    • Gutierrez-Lovera C, V\u00e1zquez-R\u00edos AJ, Guerra-Varela J, S\u00e1nchez L, de la Fuente M. The Potential of Zebrafish as a Model Organism for Improving the Translation of Genetic Anticancer Nanomedicines. Genes (Basel), 8 (12): E349 (2017). DOI:\u00a010.3390\/genes8120349<\/li>\n
    • Alonso-Nocelo M, Raimondo T, Vining K; Lopez Lopez R, de la Fuente Freire M*, Mooney D*. Matrix Stiffness and Tumor-Associated Macrophages Modulate Epithelial to Mesenchymal Transition of Human Adenocarcinoma Cells. Biofabrication, 10(3):035004 (2018). DOI:10.1088\/1758-5090\/aaafbc.<\/li>\n
    • Cordeiro, AS, Crecente-Campo J, L\u00f3pez-Bouzo B, Gonz\u00e1lez SF, de la Fuente M, Alonso MJ. Engineering polymeric nanocapsules for an efficient drainage and biodistribution in the lymphatic system. Journal of Drug Targeting, 2018.<\/li>\n
    • Vazquez-Rios AJ, Alonso-Nocelo M, Bouzo BL, Ru\u00edz J, de la Fuente M. Nanotheranostics for the management of metastatic cancer. In: Handbook of Nanomaterials for Cancer Theranostics. Ed: Joao Conde. Elsevier, USA. ISBN: 9780128133392. 2018.<\/li>\n
    • Teijeiro-Vali\u00f1o C, Novoa-Carballal R, Borrajo E, Vidal A, Alonso-Nocelo M, de la Fuente M, Lopez-Casas P, Hidalgo M, Csaba N, Alonso MJ. A multifunctional drug nanocarrier for efficient anticancer therapy. Journal of Controlled Release, 294: 154-164.<\/li>\n<\/ul>\n

      [\/et_pb_toggle][et_pb_toggle title=”Web do grupo” admin_label=”Web del grupo” _builder_version=”4.16″ _module_preset=”default” body_font=”|300|||||||” global_colors_info=”{}”]http:\/\/www.oncomet.es\/unidad-de-nano-oncologia\/
      \n[\/et_pb_toggle][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Investigador\/a l\u00edder” _builder_version=”4.16″ _module_preset=”default” text_text_color=”#FFFFFF” header_text_color=”#FFFFFF” header_2_text_align=”left” header_2_text_color=”#FFFFFF” background_color=”#10294c” custom_margin=”0px||||false|false” custom_padding=”6px||0px|6px|false|false” locked=”off” global_colors_info=”{}”]<\/p>\n

      Investigadora l\u00edder<\/h2>\n

      [\/et_pb_text][et_pb_text admin_label=”WP Team” _builder_version=”4.16″ _module_preset=”default” locked=”off” global_colors_info=”{}”]
      \n[\/et_pb_text][et_pb_text admin_label=”Investigador\/a l\u00edder” _builder_version=”4.21.0″ _module_preset=”default” text_text_color=”#FFFFFF” header_text_color=”#FFFFFF” header_2_text_align=”left” header_2_text_color=”#FFFFFF” background_color=”#10294c” custom_margin=”0px||||false|false” custom_padding=”6px||0px|6px|false|false” locked=”off” global_colors_info=”{}”]<\/p>\n

      Investigadora col\u00edder<\/h2>\n

      [\/et_pb_text][et_pb_text admin_label=”WP Team” _builder_version=”4.21.0″ _module_preset=”default” locked=”off” global_colors_info=”{}”]<\/p>\n\n

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      \u00c1REA: ONCOLOX\u00cdA Obxectivos O obxectivo principal desta unidade \u00e9 explorar estratexias innovadoras, baseadas na aplicaci\u00f3n da nanotecnolox\u00eda, para desenvolver terapias m\u00e1is eficientes e seguras, e novas ferramentas para diagn\u00f3stico avanzado […]<\/p>\n","protected":false},"author":11,"featured_media":3956,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[513],"project_tag":[],"class_list":["post-19284","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-oncologia-gl"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19284","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/comments?post=19284"}],"version-history":[{"count":0,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/19284\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media\/3956"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media?parent=19284"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_category?post=19284"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_tag?post=19284"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}