{"id":27515,"date":"2023-03-23T13:09:53","date_gmt":"2023-03-23T12:09:53","guid":{"rendered":"https:\/\/www.idisantiago.es\/?post_type=project&#038;p=27515"},"modified":"2026-02-27T10:25:28","modified_gmt":"2026-02-27T09:25:28","slug":"e056-homeostase-metabolica-e-calcificacion-vascular","status":"publish","type":"project","link":"https:\/\/www.idisantiago.es\/gl\/grupo-de-investigacion\/e056-homeostase-metabolica-e-calcificacion-vascular\/","title":{"rendered":"E056 &#8211; Homeostase metab\u00f3lica e calcificaci\u00f3n vascular"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||||false|false&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]\u00c1REA: <a href=\"https:\/\/www.idisantiago.es\/gl\/areas-de-investigacion\/a006-inflamacion\/\">CARDIOVASCULAR<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.idisantiago.es\/wp-content\/uploads\/2023\/04\/IMG_3953-scaled.jpg&#8221; title_text=&#8221;IMG_3953&#8243; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_toggle title=&#8221;Obxectivos e li\u00f1as de investigaci\u00f3n&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Objetivos y l\u00edneas de investigaci\u00f3n&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Obxectivos<\/h3>\n<p>A calcificaci\u00f3n vascular, a calcificaci\u00f3n patol\u00f3xica das estruturas cardiovasculares, \u00e9 un dos factores m\u00e1is importantes que determinan a mortalidade dos pacientes en todo o mundo. A\u00ednda que se propuxeron diferentes mecanismos sobre a patox\u00e9nese da calcificaci\u00f3n vascular, a nosa comprensi\u00f3n da patox\u00e9nese da calcificaci\u00f3n est\u00e1 lonxe de ser completa. Non obstante, nos \u00faltimos anos, est\u00e1n a xurdir alg\u00fans factores de risco, inclu\u00edndo o f\u00f3sforo s\u00e9rico elevado e a s\u00edntese defectuosa de pirofosfato. No noso laboratorio, estamos interesados \u200b\u200bno papel da homeostase do fosfato e do pirofosfato na calcificaci\u00f3n vascular. O noso laboratorio ten como obxectivo investigar os mecanismos moleculares que controlan a calcificaci\u00f3n vascular na parede arterial no envellecemento, a enfermidade renal cr\u00f3nica, a diabetes e o envellecemento acelerado (s\u00edndrome de Hutchinson-Gilford Progeria). Tam\u00e9n nos interesar\u00e1 avaliar novos marcadores e factores de risco de calcificaci\u00f3n vascular, que deber\u00edan axudar no dese\u00f1o de novos m\u00e9todos diagn\u00f3sticos e novas estratexias terap\u00e9uticas contra esta devastadora enfermidade. Dado que a calcificaci\u00f3n vascular \u00e9 un problema cun impacto sanitario e socioecon\u00f3mico notablemente alto na sociedade, a nosa investigaci\u00f3n mellorar\u00e1 a sa\u00fade.<\/p>\n<h3>Li\u00f1as de investigaci\u00f3n<\/h3>\n<ul>\n<li>\n<p>&#8220;Proxeria e calcificaci\u00f3n vascular: dieta e tratamentos&#8221;. PROGERIA RESEARCH FOUNDATION (EEUU).<\/p>\n<\/li>\n<li>\n<p>Homeostase metab\u00f3lica e calcificaci\u00f3n vascular CONSOLIDACI\u00d3N 2022 &#8211; PROXECTOS DE EXCELENCIA. XUNTA DE GALICIA<\/p>\n<\/li>\n<li>\n<p>\u201cEnfermidade renal cr\u00f3nica e calcificaci\u00f3n vascular\u201d. Fundaci\u00f3n SENEFRO y Sociedad Espa\u00f1ola de Nefrolog\u00eda (S.E.N.)<\/p>\n<\/li>\n<li>\n<p>&#8220;Calcificaci\u00f3n vascular asociada a enfermidades do envellecemento&#8221;. Ministerio de Ciencia e Innovaci\u00f3n.<\/p>\n<\/li>\n<li>\n<p>Envellecemento e calcificaci\u00f3n vascular: diagn\u00f3stico, marcadores e tratamento. Ministerio de Ciencia e Innovaci\u00f3n.<\/p>\n<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Equipo investigador&#8221; admin_label=&#8221;Equipo investigador&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><strong>L\u00edder<\/strong><br \/>Villa Bellosta, Ricardo<\/p>\n<p><strong>Predoutorais<\/strong><br \/>Flores Rico, Alicia<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Proxectos&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Proyectos (cambiar s\u00f3 codigo IDIS)&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Publicaci\u00f3ns&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Publicaciones&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Villa-Bellosta R.\u00a0<strong>ATP-based therapy prevents vascular calcification and extends longevity in a mouse model of Hutchinson-Gilford progeria syndrome.<\/strong>\u00a0<em>Proc Natl Acad Sci U S A<\/em>. 2019 Nov 19;116(47):23698-23704.<span style=\"color: #808000;\">\u00a0<strong><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1073\/pnas.1910972116\">doi: 10.1073\/pnas.1910972116.<\/a><\/strong><\/span><\/li>\n<li>Villa-Bellosta R, Hern\u00e1ndez-Mart\u00ednez E, M\u00e9rida-Herrero E, Gonz\u00e1lez-Parra E.\u00a0<strong>Impact of acetate- or citrate-acidified bicarbonate dialysate on ex vivo aorta wall calcification.<\/strong><em>\u00a0Sci Rep.<\/em>\u00a02019 Aug 6;9(1):11374.\u00a0<span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1038\/s41598-019-47934-7\"><strong>doi: 10.1038\/s41598-019-47934-7.<\/strong><\/a><\/span><\/li>\n<li>Villa-Bellosta R, Mahillo-Fern\u00e1ndez I, Ort\u00edz A, Gonz\u00e1lez-Parra E.\u00a0<strong>Questioning the Safety of Calcidiol in Hemodialysis Patients.<\/strong>\u00a0<em>Nutrients<\/em>. 2019 Apr 26;11(5):959.\u00a0<span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.3390\/nu11050959\"><strong>doi: 10.3390\/nu11050959.<\/strong><\/a><\/span><\/li>\n<li>Villa-Bellosta R.\u00a0<strong>Dietary magnesium supplementation improves lifespan in a mouse model of progeria<\/strong>\u00a0<em>EMBO Mol Med<\/em>. 2020 Oct 7;12(10):e12423.\u00a0<span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.15252\/emmm.202012423\"><strong>doi: 10.15252\/emmm.202012423.<\/strong><\/a><\/span><\/li>\n<li>Villa-Bellosta R.\u00a0<strong>New insights into endogenous mechanisms of protection against arterial calcification<\/strong>\u00a0<em>Atherosclerosis<\/em>. 2020 Aug;306:68-74.\u00a0<span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2020.03.007\"><strong>doi: 10.1016\/j.atherosclerosis.2020.03.007.<\/strong><\/a><\/span><\/li>\n<li>Villa-Bellosta R.\u00a0<strong>Vascular Calcification: Key Roles of Phosphate and Pyrophosphate<\/strong>.\u00a0<em>Int J Mol Sci<\/em>. 2021 Dec 17;22(24):13536.\u00a0<span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.3390\/ijms222413536\"><strong>doi:\u00a010.3390\/ijms222413536.<\/strong><\/a><\/span><\/li>\n<li>Villa-Bellosta R.\u00a0<strong>Role of the extracellular ATP\/pyrophosphate metabolism cycle in vascular calcification.<\/strong>\u00a0<em>Purinergic Signal<\/em>. 2022 May 5.\u00a0<span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.1007\/s11302-022-09867-1\"><strong>doi: 10.1007\/s11302-022-09867-1.<\/strong><\/a><\/span><\/li>\n<li>Hamczyk MR, Villa-Bellosta R, Quesada V, Gonzalo P, Vidak S, Nevado RM, Andr\u00e9s-Manzano MJ, Misteli T, L\u00f3pez-Ot\u00edn C, Andr\u00e9s V.\u00a0<strong>Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells<\/strong>.\u00a0<em>EMBO Mol Med<\/em>. 2019 Apr;11(4):e9736.\u00a0<span style=\"color: #808000;\"><a style=\"color: #808000;\" href=\"https:\/\/doi.org\/10.15252\/emmm.201809736\"><strong>doi: 10.15252\/emmm.201809736.<\/strong><\/a><\/span><\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle title=&#8221;Web do grupo&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Web del grupo&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|300|||||||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><a href=\"https:\/\/www.usc.es\/cimus\/es\/investigacion\/grupos-de-investigacion\/metabolic-homeostasis-and-vascular-calcification\">https:\/\/www.usc.es\/cimus\/es\/investigacion\/grupos-de-investigacion\/metabolic-homeostasis-and-vascular-calcification<\/a><\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Investigador\/a l\u00edder&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#10294c&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;6px||0px|6px|false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Investigador l\u00edder<\/h2>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;WP Team (cambiar s\u00f3 a ID pola do l\u00edder de equipo)&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"sp-wp-team-pro-wrapper wp-team-pro-preloader\" >\n\n<div id=\"sptp-27470\" class=\"sp-team-pro sptp-section sptp-new_page pagination_normal sptp-even\" >\n\n\t<div class=\"sp-team-pro-page-loading-image\"><\/div>\n\t<div class=\"sptp-grid\">\n\t\t<div class=\"sptp-row  \">\n\t\t\t\t\t<div class=\"sp-team-pro-item sptp-col-lg-1 sptp-col-md-1 sptp-col-sm-1 sptp-col-xs-1\"\n\t\t\t data-member=\"27466\">\n\t\t\t\t<div class=\"sptp-member  border-bg-around-member sptp-square\">\n\t<a class=\"sptp-member-avatar \"  href=https:\/\/www.idisantiago.es\/gl\/team\/ricardo-villa-bellosta\/ target=_blank >\n\t<div class=\"sptp-member-avatar-img-area\" data-id=\"27466\">\n\t\t<div class=\"sptp-member-avatar-img sptp-square sptp-icon-on-image none \">\n\t\t\t<div class=\"sptp-overflow-h\">\n\t\t\t\t\t\t\t\t\t<div class=\"sptp-icon text-center\">\n\t\t\t\t\t<i class=\"fa fa-plus\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"sptp_default_img\" srcset=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2023\/03\/admin-ajax-320x320.jpg\" src=\"https:\/\/www.idisantiago.es\/wp-content\/uploads\/2023\/03\/admin-ajax-320x320.jpg\" alt=\"Ricardo Villa Bellosta\" width=\"320\" height=\"320\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/a>\n\t<div class=\"sptp-member-name \">\n\t\t<h2>\n\t\t\t\t\tRicardo Villa Bellosta\t\t\t\t<\/h2>\n\t<\/div>\n<div class=\"sptp-member-email\">\n\n<i class=\"fa fa-envelope\"><\/i>\t<a href=\"#0\"  class=\"\">\n\t\t<span>ricardo.villa@usc.es<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-phone\">\n<i class=\"fa fa-phone\"><\/i>\t<a href=\"#0\"  class=\"\" >\n\t\t<span>(+34) 881 815 370<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-member-website\">\n<i class=\"fa fa-globe\"><\/i>\t<a href=\"https:\/\/orcid.org\/0000-0002-1680-552X\"  class=\"\" target=\"_blank\">\n\t\t<span>https:\/\/orcid.org\/0000-0002-1680-552X<\/span>\n\t<\/a>\n\t<\/div>\n<div class=\"sptp-read-more-button\">\n\t<a class=\"sptp-member-read-more-button\" href=\"https:\/\/www.idisantiago.es\/gl\/team\/ricardo-villa-bellosta\/\"> + INFO <\/a>\n<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div> <!-- end row -->\n\t<\/div> <!-- end grid -->\n\t\t\t<\/div>\n<\/div>\n\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c1REA: CARDIOVASCULARObxectivos A calcificaci\u00f3n vascular, a calcificaci\u00f3n patol\u00f3xica das estruturas cardiovasculares, \u00e9 un dos factores m\u00e1is importantes que determinan a mortalidade dos pacientes en todo o mundo. A\u00ednda que se [&hellip;]<\/p>\n","protected":false},"author":14,"featured_media":40803,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[508],"project_tag":[],"class_list":["post-27515","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-cardiovascular-gl"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/27515","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/comments?post=27515"}],"version-history":[{"count":13,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/27515\/revisions"}],"predecessor-version":[{"id":45301,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project\/27515\/revisions\/45301"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media\/40803"}],"wp:attachment":[{"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/media?parent=27515"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_category?post=27515"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.idisantiago.es\/gl\/wp-json\/wp\/v2\/project_tag?post=27515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}