E023 – Obesidómica

Objetivos y Líneas de investigación

Identification of new communicating signals shed by adipose tissue according to its anatomical localization, and its alteration on the development of obesity pretending as last purpose, to find new biomarkers and therapeutic targets to treat obesity:

– Proteomics analysis of visceral and subcutaneous adipose tissue secretome and its implication on obesity development
– Role of extracellular vesicles released by human adipose tissue in obesity
– Functional role and clinical application of exosomal biomarkers released by adipose tissue to the study and monitoring obesity

Functional role and clinical application of exosomal biomarkers released by adipose tissue to the study and monitoring obesity
Código del proyecto: PI19/00305
Entidad financiadora: Instituto de Salud Carlos III
Duración: 2020-2022
Cuantía: 99 200 EUR
Investigador/a principal: María Pardo Pérez

Papel de las vesículas extracelulares liberadas por el tejido adiposo humano en la obesidad
Código del proyecto: PI16/01212
Entidad financiadora: Instituto de Salud Carlos III
Duración: 2017-2019
Cuantía: 92 565 EUR
Investigador/a principal: María Pardo Pérez

Red Traslacional para la Aplicación Clínica de Vesículas Extracelulares
Código del proyecto: RED2018-102411-T
Entidad financiadora: Ministerio de Ciencia e Innovación
Duración: 2020-2023
Cuantía: 40 000 EUR
Investigador/a principal: María Pardo Pérez M. Yañez-Mo (coord.)

• Camino T, Lago-Baameiro N, Bravo SB, Molares-Vila A, Sueiro A, Couto I, Baltar J, Casanueva EF, Pardo M. Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities. Transl Res. 2022; 239:85-102.  doi: 10.1016/j.trsl.2021.01.006
• Camino T, Lago-Baameiro N, Bravo SB, Sueiro A, Couto I, Santos F, Baltar J, Casanueva FF, Pardo M. Vesicles Shed by Pathological Murine Adipocytes Spread Pathology: Characterization and Functional Role of Insulin Resistant/Hypertrophied Adiposomes. Int J Mol Sci. 2020;21(6):2252. doi: 10.3390/ijms21062252
• Camino T, Lago-Baameiro N, Martis-Sueiro A, Couto I, Santos F, Baltar J, Pardo M. Deciphering Adipose Tissue Extracellular Vesicles Protein Cargo and Its Role in Obesity. Int J Mol Sci. 2020;21(24):9366. doi: 10.3390/ijms21249366
• Pérez-Sotelo D, Roca-Rivada A, Baamonde I, Baltar J, Castro AI, Domínguez E, Collado M, Casanueva FF, Pardo M.. Lack of Adipocyte-Fndc5/Irisin Expression and Secretion Reduces Thermogenesis and Enhances Adipogenesis. Sci Rep. 2017 Nov 24;7(1):16289. doi: 10.1038/s41598-017-16602-z
• Sánchez-Herrero E, Campos-Silva C, Cáceres-Martell Y, Robado de Lope L, Sanz-Moreno S, Serna-Blasco S, Rodríguez-Festa A, Ares Trotta D, Martín-Acosta P, Patiño C, Coronado MJ, Beneitez A, Jara R, Lago-Baameiro N, Camino T, Cruz-Bermúdez A, PARDO M, González-Rumayor V, Valés-Gómez M, Provencio M, Romero A. Towards EV-based non-invasive testing. Sánchez-Herrero et al. ALK fusion transcripts can be detected in extracellular vesicles (EVs) from non-small cell lung cancer cell lines and patient plasma. Clin Chemistry.2022 Jan 12.
• de Frutos S, Griera M, Hatem-Vaquero M, Campillo S, Gutiérrez-Calabres E, García-Ayuso D, Pardo M, Calleros L, Rodríguez-Puyol M, Rodríguez-Puyol D. The integrin beta1 modulator Tirofiban prevents adipogenesis and obesity by the overexpression of integrin-linked kinase: a pre-clinical approach in vitro and in vivo. Cell Biosci. 2022;12(1):10. doi: 10.1186/s13578-022-00746-1
• Barrachina MN, Hermida-Nogueira L, Moran LA, Casas V, Hicks SM, Sueiro AM, Di Y, Andrews RK, Watson SP, Gardiner EE, Abian J, Carrascal M, Pardo M, García Á. Phosphoproteomic Analysis of Platelets in Severe Obesity Uncovers Platelet Reactivity and Signaling Pathways Alterations. Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):478-490. doi: 10.1161/ATVBAHA.120.314485
  
• Barrachina MN, Sueiro AM, Casas V, Izquierdo I, Hermida-Nogueira L, Guitián E, Casanueva FF, Abián J, Carrascal M, Pardo M, García Á. A combination of proteomic approaches defines a biomarker panel of extracellular vesicles of obese patients related to the risk of suffering cardiovascular disease. Proteomics. 2019; 19(1-2): e1800248. doi: 10.1002/pmic.201800248
• Barrachina MN, Sueiro AM, Izquierdo I, Hermida-Nogueira L, Guitián E, Casanueva FF, Farndale RW, Moroi M, Jung SM, Pardo M, García Á. GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: Elucidating potential anti-atherothrombotic targets in obesity. Atherosclerosis.2019 Feb; 281:62-70. doi: 10.1016/j.atherosclerosis.2018.12.023

https://obesidomica.wixsite.com/grupoobesidomica/quienes-somos