E031 – Oncologic endocrinology

Objectives

Breast cancer

Lines of research

• Role of the transcription factor POU1F1 in breast cancer
• Role of vitamin D analogues in breast cancer
• Mesenchymal stem cells as a treatment in various pathologies

• A Martinez-Ordoñez, S Seoane, P Cabezas, N Eiro, J Sendon-Lago, M Macia, T Garcia-Caballero, LO Gonzalez, L Sanchez, F Vizoso, R Perez-Fernandez.  Breast cancer metastasis to liver and lung is facilitated by Pit-1-CXCL12-CXCR4 axis. Oncogene 2018, 37:1430-1444. doi: 10.1038/s41388-017-0036-8
• S Seoane, A Martinez-Ordoñez, N Eiro, P Cabezas-Sainz, LO. Gonzalez, L Sanchez, F Vizoso, R Perez-Fernandez. POU1F1 transcription factor promotes breast cancer metastasis via recruitment and polarization of macrophages. Journal of Pathology 2019, 249: 381-394. doi: 10.1002/path.5324
• P Gogoi, S Seoane, R Sigüeiro, T Guiberteau, MA. Maestro, R Perez-Fernandez, N Rochel, A Mouriño. Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists. Journal of Medicinal Chemistry, 2018, 61:4928-4937.  doi: 10.1021/acs.jmedchem.8b00337
• J Sendon-Lago, L G. del Rio, N Eiro, P Diaz-Rodriguez, L Avila, LO Gonzalez, F Vizoso, R Perez-Fernandez, M Landin. Tailored hydrogels as delivery platforms of conditioned medium from mesenchymal stem cells in a model of acute colitis in mice. Pharmaceutics 2021,13:1127. doi : 10.3390/pharmaceutics13081127
• A Martínez-Ordoñez, S Seoane, L Avila, N Eiro, M Macía, E Arias, F Pereira, T García-Caballero, N Gómez-Lado, P Aguiar, F Vizoso, R Perez-Fernandez.  POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation. Oncogene 2021, 40:2725-2740. doi: 10.1038/s41388-021-01740-6