E048 – Molecular and Cellular Gastroenterology

Objectives and lines of research


Our research group focuses on the study of new mechanisms involved in the development of chronic diseases that affect the digestive tract. In particular, we have great interest in the search for new therapeutic targets for inflammatory bowel disease.

Lines of research

  • Characterization and validation of biomarkers for the response to biologic treatments in patients with inflammatory bowel disease.
  • Study of inflammation resolution mechanisms.


Research team
Conde Aranda, Javier
Predoctoral staff
Arosa García, Laura
Camba Gómez, Miguel

  • Sara Martínez Ramos; Carlos Rafael Vidal; Beatriz Malvar Fernández; Ángela Rodríguez Trillo; Douglas Veale; Ursula Fearon; Carmen Conde; Javier Conde Aranda; Timothy RDJ Radstake; Jose María Pego-Reigosa; Kris A Reedquist; Samuel García. HOXA5 is a key regulator of class 3 semaphorins expression in the synovium of rheumatoid arthritis patients. Rheumatology, 2022 Nov 18:keac654. doi: 10.1093/rheumatology/keac654.
  • Morena Scotece, Javier Conde-Aranda. Inflammation in Health and Disease: New Insights and Therapeutic Avenues. Int J Mol Sci. 2022 Jul 29;23(15):8392. doi: 10.3390/ijms23158392.
  • Laura Arosa, Miguel Camba-Gómaz, Javier Conde-Aranda. Neutrophils in Intestinal Inflammation: What We Know and What We Could Expect for the Near Future. Gastrointestinal Disorders, 2022 4(4): 263-276. doi: 10.3390/gidisord4040025.
  •  Javier Conde, Isabel Fernández-Pisonero, Myriam Cuadrado, Antonio Abad, Javier Robles-Valero, Xosé R Bustelo. Distinct Roles of Vav Family Members in Adaptive and Innate Immune Models of Arthritis. Biomedicines. 2021 Jun 19;9(6):695. doi: 10.3390/biomedicines9060695.
  • Egle Katkeviciute, Larissa Hering, Ana Montalban-Arques, Philipp Busenhart, Marlene Schwarzfischer, Roberto Manzini, Javier Conde, Kirstin Atrott, Silvia Lang, Gerhard Rogler, Elisabeth Naschberger, Vera S Schellerer, Michael Stürzl, Andreas Rickenbacher, Matthias Turina, Achim Weber, Sebastian Leibl, Gabriel E Leventhal, Mitchell Levesque, Onur Boyman, Michael Scharl, Marianne R Spalinger. Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development. J Clin Invest. 2021 Jan 4;131(1):e140281. doi: 10.1172/JCI140281.
  • Javier Conde, Clara Ruiz-Fernandez, Vera Francisco, Morena Scotece, Rodolfo Gomez, Francisca Lago, Miguel Angel Gonzalez -Gay, Jesus Pino, Ali Mobasheri, Oreste Gualillo. Dickkopf-3 (DKK3) Signalling in IL-1a-Challenged Chondrocytes: Involvement of the NF-kB Pathway. Cartilage. 2020 Jun 12. doi: 10.1177/1947603520933328.
  • L. Francisco Lorenzo-Martín, Carmen Citterio, Mauricio Menacho-Márquez, Javier Conde, Romain M. Larive, Sonia Rodríguez-Fdez, Ramón García-Escudero, Javier Robles-Valero, Myriam Cuadrado, Isabel Fernández-Pisonero, Mercedes Dosil, María A. Sevilla, María J. Montero, Pedro M. Fernández-Salguero, Jesús M. Paramio, Xosé R. Bustelo. Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms. Oncogene. 2019 Jan;38(2):209-227. doi:10.1038/s41388-018-0433-7.
  • Javier Conde, Miguel Otero, Morena Scotece, Vanessa Abella, Rodolfo Gomez, Veronica Lopez, Jesus Pino, Antonio Mera, Mary B Goldring, Oreste Gualillo. E74-Like Factor (ELF3) and Leptin, a Novel Loop Between Obesity and Inflammation Perpetuating a Pro-Catabolic State in Cartilage. Cellular Physiology and Biochemistry. 2018 Mar 13,45(6):2401-2410. doi: 10.1159/000488227.