C028 – Experimental and Observational Rheumatology

Objectives

The objective of our group is to improve the clinical management of patients with rheumatoid arthritis using observational and experimental studies with genetic, cell and molecular biology tools.
Specifically, on the one hand, the aim is to find biomarkers of poor prognosis in patients with arthritis of recent onset and to detect severe manifestations. On the other hand, it is intended to identify new therapeutic targets for the development of therapies that manage to control the disease in patients who do not respond to current treatments.

Lines of research

The group is currently working on three lines of research in rheumatoid arthritis:

1) Search for classification and prognostic biomarkers at the first visit of patients with inflammatory arthritis.
2) Search for predictive biomarkers of a rare and severe manifestation of rheumatoid arthritis, interstitial lung disease.
3) Search for new therapeutic targets in rheumatoid arthritis by studying the WNT5A signaling pathway and TRIB pseudokinases.

• Regueiro C, Casares-Marfil D, Lundberg K, Knevel R, Acosta-Herrera M, Rodriguez-Rodriguez L, Lopez-Mejias R, Perez-Pampin E, Triguero-Martinez A, Nuño L, Ferraz-Amaro I, Rodriguez-Carrio J, Lopez-Pedrera R, Robustillo-Villarino M, Castañeda S, Remuzgo-Martinez S, Alperi M, Alegre-Sancho JJ, Balsa A, Gonzalez-Alvaro I, Mera A, Fernandez-Gutierrez B, Gonzalez-Gay MA, Trouw L, Grönwall C, Padyukov L, Martin J, Gonzalez A. HLA-B*08 identified as the most associated MHC locus for anti-carbamylated protein antibody-positive/anti-CCP-negative rheumatoid arthritis. Arthritis Rheumatol. 2021; 73(6): 963-969. Dec 31. doi: 10.1002/art.41630. PMID: 33381897
• Regueiro C, Nuño L, Triguero-Martinez A, Ortiz AM, Villalba A, Bóveda MD, Martínez-Feito A, Conde C, Balsa A, González-Alvaro I, Gonzalez A. Increased disease activity in early arthritis patients with anti-carbamylated protein antibodies. Sci Rep. 2021 May 11;11(1):9945. doi: 10.1038/s41598-021-89502-y. PMID: 33976334
• Rodriguez-Trillo A, Mosquera N, Pena C, Rivas-Tobio F, Mera-Varela A, Gonzalez A, Conde C. Non-canonical WNT5A signaling through RYK contributes to aggressive phenotype of the rheumatoid fibroblast-like synoviocytes. Front Immunol 2020. 11:555245. doi: 10.3389/fimmu.2020.555245  
• Regueiro C, Rodriguez-Rodriguez L, Lopez-Mejias R, Nuño L, Triguero-Martinez A, Perez-Pampin E, Corrales A, Villalba A, Lopez-Golan Y, Abasolo L, Remuzgo-Martínez S, Ortiz AM, Herranz E, Martínez-Feito A, Conde C, Mera-Varela A, Balsa A, Gonzalez-Alvaro I, Ángel González-Gay M, Fernandez-Gutierrez B, Gonzalez A A predominant involvement of the triple seropositive patients and others with rheumatoid factor in the association of smoking with rheumatoid arthritis. Sci Rep. 2020;10:3355. doi:10.1038/s41598-020-60305-x. PMID: 32098994.
• Mosquera N, Rodriguez-Trillo A, Blanco FJ, Mera-Varela A, Gonzalez A, Conde C. All-Trans Retinoic Acid Inhibits Migration and Invasiveness of Rheumatoid Fibroblast-Like Synoviocytes. J Pharmacol Exp Ther. 2020 Feb;372(2):185-192. doi: 10.1124/jpet.119.261370. Epub 2019 Dec 4. PMID: 31801802
• Rodriguez-Martínez L, Bang H, Regueiro C, Nuño L, Triguero-Martinez A, Peiteado D, Ortiz AM, Villalba A, Martinez-Feito A, Balsa A, Gonzalez-Alvaro I, Gonzalez A. Improved classification of rheumatoid arthritis with a score including anti-acetylated ornithine antibodies. Sci Rep. 2020 Nov 6;10(1):19263. doi: 10.1038/s41598-020-73919-y. PMID: 33159095
• Regueiro C, Rodriguez-Rodriguez L, Triguero-Martinez A, Nuño L, Castaño-Nuñez AL, Villalva A, Perez-Pampin E, Lopez-Golan Y, Abasolo L, Ortiz AM, Herranz E, Pascual-Salcedo D, Martínez-Feito A, Boveda MD, Gomez-Reino JJ, Martín J, Gonzalez-Escribano MF, Fernandez-Gutierrez B, Balsa A, Gonzalez-Alvaro I, Gonzalez A. Specific Association of HLA-DRB1*03 With Anti-Carbamylated Protein Antibodies in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2019 Mar;71(3):331-339. doi: 10.1002/art.40738.
• Regueiro C, Rodríguez-Martínez L, Nuño L, Ortiz AM, illalba A, Pascual-Salcedo D, Martínez-Feito A, González-Alvaro I, Balsa A, Gonzalez A. Improved RA classification among early arthritis patients with the concordant pesence of three RA autoantibodies: analysis in two early arthritis clinics. Arthritis Res Ther. 2019 Dec 11;21(1):280. doi: 10.1186/s13075-019-2079-4.PMID: 31829260