C042 – Translational Stroke

Objectives

Study and development of new therapeutic strategies in neuronal pathologies, mainly related to cerebral ischemia. Our perspective is to try that all the knowledge developed in the field of research has a translational application and that it has an impact on the benefit of the patient.

Lines of research

1. Neuroprotection against excitotoxic damage in cerebral ischemia and ALS.
2. Study of molecular mechanisms related to hypothermia in cerebral ischemia.
3. Development of nanostructures for the encapsulation and controlled release of drugs in ischemic brain pathology.
4. Use of cell technology based on the generation of induced pluripotent stem cells (iPSCs) in monogenic diseases that cause stroke.
5. Analysis of biomarkers associated with diagnosis in cerebral stroke.

• Migliavacca M, Correa Paz C, Pérez-Mato M, Bielawski PB, Zhang I, Marie P, Hervella P, Rubio M, Maysinger D, Vivien D, Del Pino P, Pelaz B, Polo E, Campos F. Thrombolytic therapy based on lyophilized platelet-derived nanocarriers for ischemic stroke. J Nanobiotechnology 2024 DOI: 10.1186/s12951-023-02206-5
• Surpi A, Murgia M, López-Amoedo S, González-Gómez MA, Piñeiro Y, Rivas J, Perugini V, Santin M, Sobrino T, Greco P, Campos F and Dediu VA. Magnetic separation and concentration of Aβ 1-42 molecules dispersed at the threshold concentration for Alzheimer’s disease diagnosis in clinically-relevant volumes of sample. J Nanobiotechnology. 2023 Sep 15;21(1):329. DOI: 10.1186/s12951-023-02095-8.
• Alonso-Alonso ML, Sampedro-Viana A, Rodríguez-Yáñez M, López-Dequidt I, Pumar JM, Mosqueira AJ, Fernández-Rodicio S, Bazarra-Barreiros M, Sobrino T, Campos F, Castillo J, Hervella P, Iglesias-Rey R. Influence of temperature chronobiology on stroke outcome. Int J Mol Sci. 2023 Feb 13;24(4):3746. DOI: 10.3390/ijms24043746
• Alonso-Alonso ML, Sampedro-Viana A, Fernández-Rodicio S, Bazarra-Barreiros M, Ouro A, Sobrino T, Campos F, Castillo J, Hervella P, Iglesias-Rey R. Need for a paradigm shift in the treatment of cerebrovascular disease: the blood-brain barrier. Int J Mol Sci. 2022 Aug 22;23(16):9486. DOI: 10.3390/ijms23169486
• Alonso-Alonso ML, Perez Mato M, Sampedro-Viana A, Correa-Paz C, Avila-Gomez P, Sobrino T, Campos F, Castillo J, Iglesias-Rey R, Hervella P. Fibrin-Targeted Nanoparticles for Finding, Visualizing and Characterizing Blood Clots in Acute Ischemic Stroke. Pharmaceutics. 2022 Oct14; (10):2156. DOI: 10.3390/pharmaceutics14102156
• Mishra A, et al. Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 2022 Sep 30;1-15. DOI: 10.1038/s41586-022-05165-3
• Cárcel-Márquez J, et al. A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype. Front Cardiovasc Med. 2022 Jul 8; 9:940696. DOI: 10.3389/fcvm.2022.940696
• Alonso-Alonso ML, Sampedro-Viana A, Rodríguez-Yáñez M, López-Dequidt I, Pumar JM, J. Mosqueira A, Ouro A, Ávila-Gómez P, Sobrino T, Campos F, Castillo J, Hervella P, Iglesias-Rey R. Antihyperthermic Treatment in the Management of Malignant Infarction of the Middle Cerebral Artery. Clin. Med. 2022 May 19;11(10):2874. DOI: 10.3390/jcm11102874

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