C042 – Translational Stroke

Objectives

Study and development of new therapeutic strategies in neuronal pathologies, mainly related to cerebral ischemia. Our perspective is to try that all the knowledge developed in the field of research has a translational application and that it has an impact on the benefit of the patient.

Lines of research

1. Neuroprotection against excitotoxic damage in cerebral ischemia and ALS.
2. Study of molecular mechanisms related to hypothermia in cerebral ischemia.
3. Development of nanostructures for the encapsulation and controlled release of drugs in ischemic brain pathology.
4. Use of cell technology based on the generation of induced pluripotent stem cells (iPSCs) in monogenic diseases that cause stroke.
5. Analysis of biomarkers associated with diagnosis in cerebral stroke.

• Dopico-López A, Pérez-Mato M, da Silva-Candal A, Iglesias-Rey R, Rabinkov A, Bugallo-Casal A, Sobrino T, Mirelman D, Castillo J, Campos F. Inhibition of endogenous blood glutamate oxaloacetate transaminase enhances the ischemic damage. Transl Res. Transl Res. 2021 Apr;230:68-81. doi: 10.1016/j.trsl.2020.10.004
• Ávila-Gómez P, Hervella P, Da Silva-Candal A, Pérez-Mato M, Rodríguez-Yáñez M, López-Dequidt I, Pumar J M, Castillo J, Sobrino T, Iglesias-Rey R, Campos F. Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers. J Clin Med. 2020; 9(7):2108. DOI: 10.3390/jcm9072108
• Ávila-Gómez P, Vieites-Prado A, Dopico-López A, Bashir S, Fernández-Susavila H, Gubern C, Pérez-Mato M, Correa-Paz C, Iglesias-Rey R, Sobrino T, Bustamante A, Wellmann S, Montaner J, Serena J, Castillo J, Hervella P, Campos F. Cold stress protein RBM3 responds to hypothermia and is associated with good stroke outcome. Brain Comunications. 2020 Jun 4;2(2):fcaa078. doi: 10.1093/braincomms/fcaa078
• Fernández-Susavila H, Bugallo-Casal A, Castillo J, Campos F. Adult Stem Cells and Induced Pluripotent Stem Cells for Stroke Treatment. Frontiers in Neurology. 2019;10:908. doi: 10.3389/fneur.2019.00908
• Correa-Paz C, Navarro Poupard MF, Polo E, Rodríguez-Pérez M, Taboada P, Iglesias-Rey R, Hervella P, Sobrino T, Vivien D, Castillo J, Del Pino P, Campos F, Peaz B. In vivo ultrasound-activated delivery of recombinant tissue plasminogen activator from the cavity of sub-micrometric capsules. J Control Release. 2019; 308:162-171. doi: 10.1016/j.jconrel.2019.07.017
• da Silva-Candal A, Brown T, Krishnan V, Lopez-Loureiro I, Ávila-Gómez P, Pusuluri A, Pérez-Díaz A, Correa-Paz C, Hervella P, Castillo J, Mitragotri S, Campos F. Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions. J Control Release. 2019; 309:94-105. doi: 10.1016/j.jconrel.2019.07.026
• Pérez-Mato M, Iglesias-Rey R, Vieites-Prado A, Dopico-López A, Argibay B, Fernández-Susavila H, da Silva-Candal A, Pérez-Díaz A, Correa-Paz C, Günther A, Ávila-Gómez P, Isabel Loza M, Baumann A, Castillo J, Sobrino T, Campos F. Blood glutamate EAAT2-cell grabbing therapy in cerebral ischemia. EBioMedicine. 2019; 39:118-131. doi: 10.1016/j.ebiom.2018.11.024
• da Silva-Candal A, Pérez-Díaz A, Santamaría M, Correa-Paz C, Rodríguez-Yáñez M, Ardá A, Pérez-Mato M, Iglesias-Rey R, Brea J, Azuaje J, Sotelo E, Sobrino T, Loza MI, Castillo J, Campos F. Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke. Ann Neurol. 2018;84(2):260-273. doi: 10.1002/ana.25286

https://www.researchgate.net/profile/Francisco_Campos5