E032 – Preclinical animal models

Objectives

The research group focuses its studies on the zebrafish model organism, which in recent years has become a fundamental tool in biomedicine for in vivo trials.

Lines of research

• Xenotransplantations of established tumor cell lines and primary patient lines into zebrafish embryos for the analysis of effectiveness of conventional and other anticancer drugs in the development phase
• Toxicity analysis of chemical compounds and drugs in zebrafish embryos
• Toxicity and effectiveness tests of nanoparticles with anticancer compounds in zebrafish embryos and tumor-developing lines (adults)
• Model development through gene knockout (morpholinos) and transgenesis (to overexpress or inhibit gene expression)

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