E038 – Patología Musculoesquelética

Objectives and lines of research

Objectives

The objective of the different lines of research of the Musculoskeletal Pathology Group are the diseases that most prevalently affect the locomotor system. These pathologies include osteoarthritis, osteoporosis, heterotopic ossification, ankylosing spondylitis, gout, etc.
We do patient-oriented research.

Lines of research

The lines of the laboratory can be grouped into 5 large areas of knowledge:

  • New pharmacological approaches for osteoarthritis and other rheumatic inflammatory diseases.
  • Study and pharmacological modulation of bone metabolism.
  • Search for protein and cellular biomarkers for the characterization and diagnosis of heterotopic ossification.
  • Pharmacological doping of implants for the surgical approach of pathologies such as osteoarthritis.
  • Study of environmental, iatrogenic or metabolic factors harmful to the musculoskeletal system.

 

Research team

Leader
Gómez Bahamonde, Rodolfo

Research staff (established or associate)
Jorge Barreiro, Francisco Javier
Jorge Mora, Alberto Agustín
Núñez González, Cristina

 

Postdoctoral staff
Alonso Pérez, Ana
Amhaz Escanlar, Samer
Chantada Vázquez, María del Pilar
Franco Trepat, Eloi
Jorge Mora, María Teresa
Lois Iglesias, Ana Josefina
Martínez Seijas, Pedro
Misa Agostiño, María José
Piñeiro Ramil, María

Predoctoral staff
Crespo Golmar, Antía
Fernández Fernández, David
Guillán Fresco, María
López Fagúndez, Miriam
Pazos Pérez, Andrés

Technical support staff
Bravo López, Susana Belén
López López, Verónica
Pena Pena, Carmen

Proyectos

Publications
  • Eloi Franco-Trepat, Ana Alonso-Pérez, María Guillán-Fresco, Alberto Jorge-Mora, Antia Crespo-Golmar, Miriam López-Fagúndez, Andrés Pazos-Pérez, Oreste Gualillo, Susana Belén Bravo, Rodolfo Gómez Bahamonde. Amitriptyline blocks innate immune responses mediated by toll-like receptor 4 and IL-1 receptor: Preclinical and clinical evidence in osteoarthritis and gout. Br J Pharmacol. 2022;179:270–286. doi: 10.1111/bph.15707 
  • María Guillán-Fresco, Eloi Franco-Trepat, Ana Alonso-Pérez, Alberto Jorge-Mora, Miriam López-Fagúndez, Andrés Pazos-Pérez, Oreste Gualillo and Rodolfo Gómez. Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition. J. Clin. Med. 2020, 9(4), 1163. doi: 10.3390/jcm9041163 
  • Eloi Franco-Trepat, María Guillán-Fresco, Ana Alonso-Pérez, Alberto Jorge-Mora, Vera Francisco, Oreste Gualillo and Rodolfo Gómez. Visfatin Connection: Present and Future in Osteoarthritis and Osteoporosis. J. Clin. Med. 2019, 8(8), 1178; doi: 10.3390/jcm8081178 
  • Eloi Franco-Trepat, Ana Alonso-Pérez, María Guillán-Fresco, Alberto Jorge-Mora, Oreste Gualillo, Juan J. Gómez-Reino & Rodolfo Gómez Bahamonde  Visfatin as a therapeutic target for rheumatoid arthritis, Expert Opinion on Therapeutic Targets, 2019, 23:7, 607-618, doi: 10.1080/14728222.2019.1617274
  • Alberto Jorge-Mora, Samer Amhaz-Escanlar, Sabela Fernández-Pose, Cristina Lope-del-Teso, Jesús Pino-Mínguez, José Ramón Caeiro-Rey, Juan Pretell-Mazzini, Rodolfo Gómez. Early outcomes of locked noncemented stems for the management of proximal humeral fractures: a comparative study. Journal of Shoulder and Elbow Surgery, 2019, 28:1, 48 – 55. doi: 10.1016/j.jse.2018.05.036
  • Alberto Jorge-Mora, Naroa Imaz, Eva Garcia-Lecina, Gerard M. O’Connor, Rodolfo Gómez-Vaamonde, Ana Alonso-Pérez, Eloi Franco-Trepat, Carlota García-Santiago, Jesús Pino-Minguez, Daniel Nieto. In vitro response of bone marrow mesenchymal stem cells (hBMSCs) on laser-induced periodic surface structures for hard tissue replacement: Comparison between tantalum and titanium. Optics and Lasers in Engineering, 2018, 111, 34-41. doi: 10.1016/j.optlaseng.2018.07.008
  • Alonso-Pérez A, Franco-Trepat E, Guillán-Fresco M, Jorge-Mora A, López V, Pino J, Gualillo O and Gómez R. Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function. Front. Physiol., 2018, 9:504. doi: 10.3389/fphys.2018.00504
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