Objectives and lines of research
Objectives
To study potential diagnostic and therapeutic strategies for neurological diseases for their future use in routine clinical practice.
Lines of research
- Early diagnosis, biomarkers, and treatment of Alzheimer’s disease and other dementia.
- Diagnostic and prognostic biomarkers of cerebrovascular disease.
- Diagnosis, biomarkers, and treatment of epilepsy.
- Biomarkers, diagnosis, and treatment of multiple sclerosis.
- Biomarkers, diagnosis, and treatment of migraine.
Research team
Projects
Estudio Observacional para evaluar el cumplimiento terapéutico de los pacientes con esclerosis múltiple en tratamiento con terapias modificadoras de la enfermedad de primera línea. Estudio Compliance. E-0232. NOV-TME-2010-01.
Estudio de biomarcadores en LCR para el diagnóstico de EA prodrómica en pacientes con deterioro cognitivo ligero. Estudio PREDEM. ENOSM/2012/01. NOV-SNC-2011-01.
Estudio observacional, prospectivo, multinacional, multicéntrico, que compara la efectividad de Safinamida, Rasagilina y otros “tratamientos estándar” como tratamiento complementario a la levodopa (L-dopa) en pacientes con enfermedad de Parkinson (EP) fluctuante. E-2203. Z7219N04 (ZAM-SAF-2019-01).
Publications
- R Pego-Reigosa, S López-López, ME Vázquez-López, V Armesto-Pérez, F Brañas-Fernández, F Martínez-Vázquez, R Piñeiro-Bolaño, JA Cortés-Laíño. Sea wave-induced internal carotid artery dissection. Neurology 2005 Jun 14; 64(11):1980. : doi: 10.1212/01.WNL.0000163855.78628.42
- Pego-Reigosa R, Vázquez-López ME, Iglesias-Gómez S, Martinez-Vázquez F. Association between chronic paroxysmal hemicrania and primary trochlear headache: pathophysiology and treatment. Cephalalgia 2006; 26 (10): 1252-1254. doi: 10.1111/j.1468-2982.2006.01202.x
- Muñoz D, Escartín A, Dapena D, Coret F, Fernández-Uría D, Pérez D, Casanova B, Guijarro-Castro C, Munteis E, del-Campo Amigo M, Pego R, Calles C, García-Rey C, Monsalve N, Sánchez-Matienzo D. Adverse events during the titration phase of interferon-beta in remitting-relapsing multiple sclerosis are not predicted by body mass index nor by pharmacodynamic biomarkers. BMC Neurol. 2013 Jul 11;13 :82. doi: 10.1186/1471-2377-13-82
- Alberte-Woodward M, da Silva-França CF, Rodríguez-Gay I, Pego-Reigosa R. Safety of Intravenous Thrombolysis for Acute Stroke in Patients with an Active Malignancy: Case Series and Review of the Literature. Eur Neurol. 2019;81(3-4): 163-166.
- Fernández-Cabrera A, García-De Soto J, Pego-Reigosa R, Suárez-Quintanilla J. Relationship between periodontitis and cerebral atrophy: A cross-sectional study. Dent Med Probl. 2025 May-Jun;62(3): 493-498.
- García-de Soto J, Castro-Mosquera M, Pouso-Diz JM, Fernández-Cabrera A, Rodríguez-Arrizabalaga M, Debasa-Mouce M, Camino-Castiñeiras J, Minguillón Pereiro AM,
- Aramburu-Núñez M, Romaus-Sanjurjo D, Aldrey JM, Pego-Reigosa R, Pías-Peleteiro JM, Sobrino T, Ouro A. Unraveling the Role of Autotaxin and Lysophosphatidic Acid in Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Potential. Int J Mol Sci. 2025 Jul 23;26(15): 7068.
- Fernández-Cabrera A, Santamaría-Montero P, García de-Soto J, Pego-Reigosa R. MonoPER study: Effectiveness and tolerability of PERampanel in monotherapy in real-world after 12 months of treatment. Epilepsia Open. 2025 Oct;10(5): 1587-1594.
- Fernández-Cabrera A, Santamaría-Montero P, Soto JG, Figueira-Gómez A, Rodríguez-Botana M, Pérez-Regojo B, Pego-Reigosa R. EPIDEP: Prevalence of undiagnosed depression in an epilepsy outpatient clinic. Epilepsy Behav Rep. 2025 Aug 9;32:100819.
