C032 -Molecular Imaging

Objectives

Development of new molecular imaging biomarkers for diagnosis and treatment.

Lines of research

• New PET imaging biomarkers for early diagnosis of neurodegenerative diseases
• New PET imaging biomarkers for monitoring and personalization of cancer treatments

• Manuel Piñeiro-Fiel, Alexis Moscoso, Lucía Lado-Cacheiro, María Pombo-Pasín, David Rey-Bretal, Noemí Gómez-Lado, Cristina Mondelo-García, Jesús Silva-Rodríguez, Virginia Pubul, Manuel Sánchez, Álvaro Ruibal & Pablo Aguiar. Is FDG-PET texture analysis related to intratumor biological heterogeneity in lung cancer? Eur Radiol 31,4156–4165 (2021). doi: 10.1007/s00330-020-07507-z
• Moscoso A, Silva-Rodríguez J, Aldrey JM, Cortés J, Pías-Peleteiro JM, Ruibal Á, Aguiar P; Alzheimer’s Disease Neuroimaging Initiative. ¹⁸F-florbetapir PET as a marker of myelin integrity across the Alzheimer’s disease spectrum. Eur J Nucl Med Mol Imaging. 2021 Sep 28. doi: 10.1007/s00259-021-05493-y
• José Paredes-Pacheco, Francisco Javier López-González, Jesús Silva-Rodríguez, Nikos Efthimiou, Aida Niñerola-Baizán, Álvaro Ruibal, Núria Roé-Vellvé, Pablo Aguiar. SimPET—An open online platform for the Monte Carlo simulation of realistic brain PET data. Validation for 18F-FDG scans. Med. Phys., 2021, 48: 2482-2493. doi: 10.1002/mp.14838
• David Rey-Bretal, Alexis Moscoso, Noemí Gómez-Lado, Anxo Fernández-Ferreiro, Jesús Silva-Rodríguez, Álvaro Ruibal & Pablo Aguiar. Feasibility of Longitudinal Brain PET with Real-Time Arterial Input Function in Rats. Mol Imaging Biol 23,350–360 (2021). doi: 10.1007/s11307-020-01556-y
• Francisco J. López-González, Jesús Silva-Rodríguez, José Paredes-Pacheco, Aida Niñerola-Baizán, Nikos Efthimiou, Carmen Martín-Martín, Alexis Moscoso, Álvaro Ruibal, Núria Roé-Vellvé, Pablo Aguiar. Intensity normalization methods in brain FDG-PET quantification. NeuroImage, 2020,  222, 117229. doi: 10.1016/j.neuroimage.2020.117229
• Noemí Gómez-Lado, Esteban López-Arias, Ramón Iglesias-Rey, Lucía Díaz-Platas, Santiago Medín-Aguerre, Anxo Fernández-Ferreiro, Adrián Posado-Fernández, Lara García-Varela, Manuel Rodríguez-Pérez, Francisco Campos, Pablo Del Pino, Álvaro Ruibal, Juan Pardo-Montero, José Castillo, Pablo Aguiar and Tomás Sobrino. [18F]-FMISO PET/MRI Imaging Shows Ischemic Tissue around Hematoma in Intracerebral Hemorrhage. Mol. Pharmaceutics 2020, 17, 12, 4667–4675. doi/10.1021/acs.molpharmaceut.0c00932

https://www.usc.es/cimus/es/investigacion/grupos-de-investigacion/molecular-imaging-biomarkers-and-pharmacokinetic-modelling