E057 – Translational endocrinology

Objectives

Our goal is to find new targets for the treatment of obesity and its associated diseases by studying the regulation of endocrine factors or metabolic signals on energy balance and lipid metabolism.

Lines of research

• Search for new targets for the treatment of obesity: It is intended to initiate a new line of translational research from a very attractive perspective, but at the same time very unknown and innovative, such as the search for molecular links between neurodegenerative diseases and obesity.

• Search for new targets for the treatment of liver diseases: Although the group leader has a long history in the field of obesity and metabolism, because the incidence of non-alcoholic fatty liver/non-alcoholic steatohepatitis is increasing basically due to the large increase in patients with obesity and type 2 diabetes,he decided to start a new line of research complementary to the previous one.

• Prida E, Álvarez-Delgado Sara, Pena-león V, Pérez-Lois R, Ferno J, Seoane LM, Quiñones M, O Al Massadi. Liver brain crosstalk: focus in FGF-21 a systematic review. Int. J. Mol. Sci. 2022, 23(21), 13318; doi: 10.3390/ijms232113318.
• Pena-Leon V, Folgueira C, Barja-Fernández S, Pérez-Lois R, Da Silva Lima N, Martin M, Heras V, Martinez-Martinez S, Valero P, Iglesias C, Duquenne M, Al-Massadi O, Beiroa D, Souto Y, Fidalgo M, Sowmyalakshmi R, Guallar D, Cunarro J, Castelao C, Senra A, González-Saenz P, Vázquez-Cobela R, Leis R, Sabio G, Mueller-Fielitz H, Schwaninger M, López M, Tovar S, Casanueva FF, Valjent E, Diéguez C, Prevot V, Nogueiras R, Seoane LM. Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21. PMID: 35879461. Nat Metab. 2022 Jul;4(7):901-917. doi: 10.1038/s42255-022-00602-z.
• O Al-Massadi, Parini P, Ferno J, Luquet S Quiñones M. Metabolic Actions of the Growth Hormone-Insulin Growth Factor-1 axis and its Interaction with the Central Nervous System. Rev Endocr Metab Disord. 2022 Oct;23(5):919-930. doi: 10.1007/s11154-022-09732-x.
• Omar Al-Massadi, Carlos Dieguez, Marc Schneeberger, Miguel López, Markus Schwaninger, Vincent Prevot, Ruben Nogueiras. Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis. Nat Rev Endocrinol. 2021 Dec;17(12):745-755. doi: 10.1038/s41574-021-00559-1.
• Al-Massadi O*, Mastrolia V*, De Pins B, Girault JA. Pyk2 in dorsal hippocampus plays a selective role in spatial memory and synaptic plasticity. Sci Rep. 2021 Aug 11;11(1):16357. doi: 10.1038/s41598-021-95813-x.
• Mar Quiñones, René Hernández-Bautista, Daniel Beiroa, Violeta Heras, Francisco L. Torres-Leal, Brian Y.H. Lam, Ana Senra, Johan Fernø J, Alicia García Gómez-Valadés, Markus Schwaninger, Vincent Prevot, Giles Yeo, Marc Claret, Miguel López, Carlos Diéguez C, Omar Al-Massadi, Ruben Nogueiras. Sirt3 in POMC neurons controls energy balance in a sex- and diet- dependent manner. PMID: 33744652. Redox Biol. 2021 Mar 13;41:101945. doi: 10.1016/j.redox.2021.101945.
• Quinones M, Ferno J, Al-Massadi O. Ghrelin and liver disease. Rev Endocr Metab Disord. 2020 Mar;21(1):45-56. doi: 10.1007/s11154-019-09528-6.