Biomarkers Platform in Biological Fluids (SIMOA HD-X)

Quanterix SIMOA HD-X AnalyzerTM

Single Molecule Array (SIMOA®) technology is a highly automated, ultrasensitive digital immunoassay platform that allows the measurement of extremely low levels of biomarkers in biological fluids. Its sensitivity is 1,000 times higher than that of conventional immunoassays, with the ability to detect concentrations in the femtomolar range. The Quanterix SIMOA HD-X Analyzer™, compatible with SIMOA HD-X assay kits, can perform simultaneous measurements of up to 4 biomarkers from a minimal sample volume, using a single assay without compromising sensitivity or accuracy.
Available biomarkers include: neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), amyloid proteins (Aβ40 and Aβ42), various phosphorylated forms of Tau protein (pTau181, pTau231 and pTau217), Brain-derived Tau (BD-Tau), and other biomarkers in areas such as neurology, oncology, immunology/inflammation, infectious diseases and cardiology.

Quanterix video: https://youtu.be/eIBonJWFoYA?si=9UJlcgonUDEh877v

Video about microspheres: https://youtu.be/Bv58mBJD7X8?si=hYCJ7qmtVzZ5Dlm_

The IDIS SIMOA HD-X platform, dedicated to the detection of biomarkers in biological fluids, was established in 2023. It uses an automated system that allows the detection of biomarkers in various biological samples (such as plasma, serum, CSF, urine and cell lysates ) at femtomolar concentrations (1×10^-15), using advanced immunodetection technology. This platform facilitates the precise identification of minimum concentrations of biomarkers, the search for new markers and the development of innovative assays for application in daily clinical practice.

The SIMOA equipment is located in a temperature-controlled room, which is equipped with freezers (-80ºC and -20ºC) and refrigerators (4ºC) to guarantee adequate storage of samples and reagents from the analysis kits. In addition, it has a specialized human team and offers analytical services and assay validation for various pathologies and biofluids.

We provide support in the design and execution of biomarker diagnostic tests using the Single Molecule Array (SIMOA) technique in various types of biological fluids, in order to generate knowledge that can be published or patented.

What should users do?
I. Contact the person responsible for the team, Roberto Carlos Agís Balboa (roberto.carlos.agis.balboa@sergas.es) or Lara Vidal Nogueira (lara.vidal.nogueira@sergas.es), to inform your intention to use the equipment. The message must specify the type of test, the samples to be analyzed and the number of samples.

II. Purchase the kit corresponding to the assay through the official Quanterix website (https://www.quanterix.com/). Contact Sara Castagnola (europecustomerservice@quanterix.com / scastagnola@quanterix.com) for the acquisition of kits and commercial inquiries.

III. Send the necessary samples and kit to the following address:

Attention: Roberto Carlos Agís Balboa or Lara Vidal Nogueira
Office 21 / ITEN Group
Health Research Institute of Santiago de Compostela (IDIS)
Santiago de Compostela University Hospital Complex (CHUS)
Consultation Building (floor -2)
Travesía da Choupana s/n, 15706 Santiago de Compostela

What will we do?
I. Design of the experiment according to the specific instructions of each kit, using the SIMOA™ HD-X Analyzer software.

II. Test execution.

III. Sending results by email in Excel and PDF format within 1-2 business days since kit and samples reception.

Fees.

VAT not included.

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