ÁREA: NEUROCIENCIAS
Obxectivos e liñas de investigación
Obxectivos
Os obxectivos principais son:
a) Estudar os mediadores da resposta inflamatoria asociada ao trauma cirúrxico e analizar a compartimentalización desta resposta na cavidade pericárdica e cavidade pleural.
b) Estudar a asociación entre o fenotipo da graxa periaórtica e os procesos de apotose da túnica media arterial.
c) Análise proteómico da graxa subcutánea, epicárdico-visceral e perivascular e a súa resposta a diferentes estímulos
Liñas de investigación
1.Mediadores inflamatorios en tecido graxo subcutáneo e a graxa visceral
2. Resposta inflamatoria secundaria á agresión cirúrxica
3. Dexeneración tisular de material protésico y resistencia de materiales
Equipo investigador
Publicacións
- El Diasty MM, Pérez L, Souaf S, Eiras S, Fernández González AL. Compartmentalization of the Inflammatory Response in the Pericardial Cavity in Patients Undergoing Cardiac Surgery. Int J Mol Sci 2024: 25: 13720. doi: 10.3390/ijms252413720.
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El Diasty MM, Rodríguez J, Pérez L, Eiras S, Fernández González AL. Accumulation of Inflammatory Mediators in the Normal Pericardial Fluid. Int J Mol Sci 2023; 25: 157. doi: 10.3390/ijms25010157.
- Fernández L, Monzonís AM, El-Diasty MM, Alvarez-Lorenzo C, Concheiro A, Fernández AL. Biomechanical characteristics of different methods of neo-chordal fixation to the papillary muscles. J Card Surg 2022; 37: 4408-4415. doi: 10.1111/jocs.17027.
- Fu X, Almeglo C, Fernández AL, Martínez Cereijo JM, Iglesias Alvarez D, Duran Muñoz D, García Caballero T, González Juanatey JR, Rodríguez Mañero M, Eiras S. The effect of mineralocorticoid receptor 3 antatonists on anti-inflammatory and anti-fatty acid transport. Profile in patients with heart failure . Cells 2022; 11: 1264. doi: 10.3390/cells11081264.
- King M, Stambulic T, Payne D, Fernández AL, El-Diasty MM. The use of sutureless and rapid-deployment aortic valve prosthesis in patients with bicuspid aortic valve: a focused review. J Card Surg 2022; 37: 3355-3362. doi: 10.1111/jocs.16795.
- Chen X, Sartor C, Zhang S, Baranchuk A, Ross-White A, Fernández AL, El-Diasty MM. Effectiveness of intra-operative topical amiodarone for prevention of post- cardiac surgery new onset atrial fibrillation: a review of current evidence. J Card Surg 2022; 37: 5371-5378. doi: 10.1111/jocs.17190.
- Almengló C, Fu X, Flores-Arias MT, Fernández AL, Viñuela JE, Martínez-Cereijo JM, Durán D, Rodríguez-Mañero M, González-Juanatey JR, Eiras S. Synergism between obesity and HFpEF on neutrophils phenotype and its regulation by adipose tissue- molecules and SGLT2i dapagliflozin. J Cell Mol Med 2022; 26: 4416-4427. doi:10.1111/jcmm.17466.
- Abuelo JM, García Carro J, Canerio J, El-Diasty MM, Fernández AL. Left atrial myxoma infected with Fusobacterium nucleatum. Port J Card Thorac Vasc Surg 2022; 29: 55-57. doi: 10.48729/pjctvs.287.
