C027 – Interaccións Neuroendocrinas en Enfermidades Reumáticas e Inflamatorias (Neirid)

Obxectivos

Dr. Gualillo’s primary research focussed on the immunometabolic molecular signals triggered by adipokines and on the pathways through which these molecules are involved in rheumatic diseases and in the inflammatory response of chondrocytes, synovial cell, and immune cells in particular in osteoarthritis, rheumatoid arthritis and intravertebral disc cells degeneration. Over the past years, his group has contributed to multiple aspects of research on the roles of adipokines in inflammation in rheumatic disorders and to define the molecular basis of immunometabolic responses in chondrocytes, cartilage and intravertebral disc. Dr. Gualillo’s group is also involved in pre-clinical research applications of herbs and natural products in medicine, including studies of herb-drug interactions and other aspects of the safety and pharmacological properties of herbal medicines.
Very recently, the group has focused on the critical importance of biomaterials in the creation of new devices and systems for drug delivery and cell-based regenerative medicine.

Liñas de investigación

1- Identification of extracellular and intracellular signaling of novel adipokines in cartilage and other joint tissues
2- Interactions between innate and adaptive immune system and adipose tissue: role of adipokines in the modulation of T regulatory cells and other immune cells subsets
3- Adipokines and intravertebral disc pathophysiology. Effects of adipokines on cartilage relevant trandscription factors
4- Effect of micronutrients of herbal and algae extract on cartilage and disc cells pathophysiology
5- Kinase inhibitors tom target inflammatory response in cartilage

Líder
Gualillo, Oreste

• Francisco V, Pino J, González-Gay MÁ, Lago F, Karppinen J, Tervonen O, Mobasheri A, Gualillo O. A new immunometabolic perspective of intervertebral disc degeneration. Nat Rev Rheumatol. 2021 Nov 29. doi: 10.1038/s41584-021-00713-z. PMID: 34845360.
• Seoane-Collazo P, Rial-Pensado E, Estévez-Salguero Á, Milbank E, García-Caballero L, Ríos M, Liñares-Pose L, Scotece M, Gallego R, Fernández-Real JM, Nogueiras R, Diéguez C, Gualillo O, López M. Activation of hypothalamic AMPK ameliorates metabolic complications of experimental arthritis. Arthritis Rheumatol. 2021 Aug 16. doi: 10.1002/art.41950. PMID: 34398520.
• Ruiz-Fernández C, Gonzalez-Rodríguez M, Francisco V, Rajab IM, Gómez R, Conde J, Lago F, Pino J, Mobasheri A, Gonzalez-Gay MA, Mera A, Potempa LA, Gualillo O. Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes. Lab Invest. 2021 Dec;101(12):1550-1560. doi: 10.1038/s41374-021-00584-8. Epub 2021 Mar 25. PMID: 33767361
• Conde J, Ruiz-Fernandez C, Francisco V, Scotece M, Gómez R, Lago F, Gonzalez-Gay MA, Pino J, Mobasheri A, Gualillo O. Dickkopf-3 (DKK3) Signaling in IL-1α-Challenged Chondrocytes: Involvement of the NF-κB Pathway. Cartilage. 2020 Jun 12:1947603520933328. doi: 10.1177/1947603520933328. PMID: 32532182.
• Francisco V, Ruiz-Fernández C, Pino J, Mera A, González-Gay MA, Gómez R, Lago F, Mobasheri A, Gualillo O. Adipokines: Linking metabolic syndrome, the immune system, and arthritic diseases. Biochem Pharmacol. 2019 Jul;165:196-206. doi: 10.1016/j.bcp.2019.03.030. Epub 2019 Mar 22. PMID: 30910694.
• Francisco V, Ruiz-Fernández C, González-Rodríguez M, Cordero-Barreal A, Pino J, Viñuela JE, Lago F, Conde J, Gómez R, Carvalho GR, Costa Pereira TM, Campos-Toimil M, Gualillo O. Evaluation of Virola oleifera activity in musculoskeletal pathologies: Inhibition of human multiple myeloma cells proliferation and combination therapy with dexamethasone or bortezomib. J Ethnopharmacol. 2021 May 23;272:113932. doi: 10.1016/j.jep.2021.113932. Epub 2021 Feb 18. PMID: 33609728.
• Francisco V, Tovar S, Conde J, Pino J, Mera A, Lago F, González-Gay MA, Dieguez C, Gualillo O. Levels of the Novel Endogenous Antagonist of Ghrelin Receptor, Liver-Enriched Antimicrobial Peptide-2, in Patients with Rheumatoid Arthritis. Nutrients. 2020 Apr 6;12(4):1006. doi: 10.3390/nu12041006. PMID: 32268520; PMCID: PMC7231392.
• Francisco V, Ruiz-Fernández C, Lahera V, Lago F, Pino J, Skaltsounis L, González-Gay MA, Mobasheri A, Gómez R, Scotece M, Gualillo O. Natural Molecules for Healthy Lifestyles: Oleocanthal from Extra Virgin Olive Oil.<2Fstrong> J Agric Food Chem. 2019 Apr 10;67(14):3845-3853. doi: 10.1021/acs.jafc.8b06723. Epub 2019 Mar 27. PMID: 30875206.