GRUPOS DE INVESTIGACIÓN

E063 – Neuroendocrine Regulation of Metabolism (NeuRoMet)

ÁREA: ENDOCRINOLOGÍA, NUTRICIÓN Y METABOLISMO
Equipo investigador
Líder
González García, Ismael

 

Miembros
Jose Vattathara, Jane
Fernández Malvido, Nicolás

  
Publicacións
  • Dragano NRV, Milbank E, Haddad-Tóvolli R, Garrido-Gil P, Nóvoa E, Fondevilla MF, Capelli V, Zanesco AM, Solon C, Morari J, Pires L, Estevez-Salguero Á, Beiroa D, González-García I, Barca-Mayo O, Diéguez C, Nogueiras R, Labandeira- García JL, Ulven ER, Ulven T, Claret M, Velloso LA, Lopez M. Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance. PMID: 38036170. Mol Metab. 2023 Nov 29:101840.
  • Gruber T, Lechner F, Murat C, Contreras RE, Sanchez-Quant E, Miok V, Makris K, Le Thuc O, González-García I, García-Clave E, Althammer F, Krabichler Q, DeCamp LM, Jones RG, Lutter D, Williams RH, Pfluger PT, Müller TD, Woods SC, Pospisilik JA, Martinez-Jimenez CP, Tschöp MH, Grinevich V, García-Cáceres C. High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling. PMID: 37864798 Cell Rep. 2023 Oct 31;42(10):113305.
  • González-García I, García-Cáceres C. Astrocytic GABA in LHA is an obesity ‘thermostat’. PMID: 37653042. Nat Metab. 2023 Sep;5(9):1454-1455.
  • González García I, López M. Fezolinetant for menopausal hot flashes and night sweats. PMID: 37423792. Trends Pharmacol Sci. 2023 Sep;44(9):635-636.
  • Zagmutt S, Mera P, González-García I, Ibeas K, Romero MDM, Obri A, Martin B, Esteve-Codina A, Soler-Vázquez MC, Bastias-Pérez M, Cañes L, Augé E, Pelegri C, Vilaplana J, Ariza X, García J, Martinez-González J, Casals N, López M, Palmiter R, Sanz E, Quintana A, Herrero L, Serra D. CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst. PMID: 36966335. Biol Sex Differ. 2023 Mar 25;14(1):14.
  • González-García I, García-Clavé E, Cebrian-Serrano A, Le Thuc O, Contreras RE, Xu Y, Gruber T, Schriever SC, Legutko B, Lintelmann J, Adamski J, Wurst W, Müller TD, Woods SC, Pfluger PT, Tschöp MH, Fisette A, García-Cáceres C. Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1. PMID: 36889283.  Cell Metab. 2023 Mar 7;35(3):438-455.e7.
  • Lutomska LM, Miok V, Krahmer N, González García I, Gruber T, Le Thuc O, Murat CD, Legutko B, Sterr M, Saher G, Lickert H, Müller TD, Ussar S, Tschöp MH, Lutter D, García-Cáceres C. Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner. PMID: 35802021. Glia. 2022 Nov;70(11):2062-2078.
  • González-García I, Urisarri A, Nogueiras R, Diéguez C, Couce ML, López M. An updated view on human neonatal thermogenesis. PMID: 35165402. Nat Rev Endocrinol. 2022 May;18(5):263-264.
  • González-García I, Freire-Agulleiro Ó, Nakaya N, Ortega FJ, Garrido-Gil P, Liñares-Pose L, Fernø J, Labandeira-Garcia JL, Diéguez C, Sultana A, Tomarev SI, Fernández-Real JM, López M. Olfactomedin 2 deficiency protects against diet-induced obesity. PMID: 35026233.  Metabolism. 2022 Apr;129:155122.
  • Tarquis-Medina M, Scheibner K, González-García I, Bastidas-Ponce A, Sterr M, Jaki J, Schirge S, García-Cáceres C, Lickert H, Bakhti M. Synaptotagmin-13 Is a Neuroendocrine Marker in Brain, Intestine and Pancreas. PMID: 34830411.  Int J Mol Sci. 2021 Nov 20;22(22):12526.
  • Milbank E, Dragano NRV, González-García I, Garcia MR, Rivas-Limeres V, Perdomo L, Hilairet G, Ruiz-Pino F, Mallegol P, Morgan DA, Iglesias-Rey R, Contreras C, Vergori L, Cuñarro J, Porteiro B, Gavaldà-Navarro A, Oelkrug R, Vidal A, Roa J, Sobrino T, Villarroya F, Diéguez C, Nogueiras R, García-Cáceres C, Tena-Sempere M, Mittag J, Carmen Martínez M, Rahmouni K, Andriantsitohaina R, López M. Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation. PMID: 34675439.  Nat Metab. 2021 Oct;3(10):1415-1431.
  • Urisarri A, González-García I, Estévez-Salguero Á, Pata MP, Milbank E, López N, Mandiá N, Grijota-Martinez C, Salgado CA, Nogueiras R, Diéguez C, Villarroya F, Fernández-Real JM, Couce ML, López M. BMP8 and activated brown adipose tissue in human newborns. PMID: 34489410.  Nat Commun. 2021 Sep 6;12(1):5274.
  • Meneyrol K, Estévez-Salguero Á, González-García I, Guitton J, Taouis M, Benomar Y, Magnan C, López M, Le Stunff H. Ovarian insufficiency impairs glucose-stimulated insulin secretion through activation of hypothalamic de novo ceramide synthesis. PMID: 34371064.  Metabolism. 2021 Oct;123:154846.
  • González-García I, García-Cáceres C. Hypothalamic Astrocytes as a Specialized and Responsive Cell Population in Obesity. PMID: 34201099.  Int J Mol Sci. 2021 Jun 8;22(12):6176.
  • González-García I, Gruber T, García-Cáceres C. Insulin action on astrocytes: From energy homeostasis to behaviour. PMID: 33724579.  J Neuroendocrinol. 2021 Apr;33(4):e12953.
  • González-García I, Le Thuc O, Jastroch M, García-Cáceres C. Divide et impera: How mitochondrial fission in astrocytes rules obesity. PMID: 33400974. Mol Metab. 2021 Mar;45:101159.
  • Badenes M, Amin A, González-García I, Félix I, Burbridge E, Cavadas M, Ortega FJ, de Carvalho É, Faísca P, Carobbio S, Seixas E, Pedroso D, Neves-Costa A, Moita LF, Fernández-Real JM, Vidal-Puig A, Domingos A, López M, Adrain C. Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis. PMID: 31918923. Mol Metab. 2020 Jan;31:67-84.
  • González-García I, Milbank E, Martinez-Ordoñez A, Diéguez C, López M, Contreras C. HYPOTHesizing about central comBAT against obesity. PMID: 31845114.  J Physiol Biochem. 2020 May;76(2):193-211.
  • González-García I, Milbank E, Diéguez C, López M, Contreras C. Glucagon, GLP-1 and Thermogenesis. PMID: 31337027.  Int J Mol Sci. 2019 Jul 13;20(14):3445.
  • Blankenhaus B, Braza F, Martins R, Bastos-Amador P, González-García I, Carlos AR, Mahu I, Faisca P, Nunes JM, Ventura P, Hoerr V, Weis S, Guerra J, Cardoso S, Domingos A, López M, Soares MP. Ferritin regulates organismal energy balance and thermogenesis. PMID: 30954544.  Mol Metab. 2019 Jun;24:64-79.
  • González-García I, Contreras C, Estévez-Salguero Á, Ruíz-Pino F, Colsh B, Pensado I, Liñares-Pose L, Rial-Pensado E, Martínez de Morentin PB, Fernø J, Diéguez C, Nogueiras R, Le Stunff H, Magnan C, Tena-Sempere M, López M. Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress. PMID: 30304681. Cell Rep. 2018 Oct 9;25(2):413-423.e5.
  • Liñares-Pose L, Rial-Pensado E, Estévez-Salguero Á, Milbank E, González- García I, Rodríguez C, Seoane-Collazo P, Martinez-Sánchez N, Nogueiras R, Prieto D, Diéguez C, Contreras C, López M. Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake. PMID: 30018241.  Genes (Basel). 2018 Jul 17;9(7):357.
  • González-García I, Martínez de Morentin PB, Estévez-Salguero Á, Contreras C, Romero-Picó A, Fernø J, Nogueiras R, Diéguez C, Tena-Sempere M, Tovar S, López M. mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol. PMID: 29914932.  J Endocrinol. 2018 Sep;238(3):177-186.
  • González-García I, Tena-Sempere M, López M. Estradiol Regulation of Brown Adipose Tissue Thermogenesis. PMID: 29224101. Adv Exp Med Biol. 2017;1043:315 335.
  • Skrede S, González-García I, Martins L, Berge RK, Nogueiras R, Tena-Sempere M, Mellgren G, Steen VM, López M, Fernø. Lack of Ovarian Secretions Reverts the Anabolic Action of Olanzapine in Female Rats. PMID: 29020342.  J. Int J Neuropsychopharmacol. 2017 Dec 1;20(12):1005-1012.
  • González García I, Fernø J, López M. Central Oxytocin and Energy Balance: More Than Feelings. PMID: 28911180. Endocrinology. 2017 Sep 1;158(9):2713-2715.
  • Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. PMID: 28683288.Cell Metab. 2017 Jul 5;26(1):212-229.e12.
  • González-García I, López M. UCP1 and T3: A key “(un)couple” in energy balance. PMID: 28349091. Temperature (Austin). 2016 Aug 5;4(1):18-20.
  • González-García I, Fernø J, Diéguez C, Nogueiras R, López M. Hypothalamic Lipids: Key Regulators of Whole Body Energy Balance. PMID: 27728904. Neuroendocrinology. 2017;104(4):398-411.
  • Contreras C, González-García I, Seoane Collazo P, Martínez-Sánchez N, Liñares-Pose L, Rial-Pensado E, Fernø J, Tena-Sempere M, Casals N, Diéguez C, Nogueiras R, López M. Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity. PMID: 27634226. Diabetes. 2017 Jan;66(1):87-99.
  • Martins L, Seoane-Collazo P, Contreras C, González-García I, Martínez- Sánchez N, González F, Zalvide J, Gallego R, Diéguez C, Nogueiras R, Tena- Sempere M, López M. A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance. PMID: 27524625. Cell Rep. 2016 Aug 23;16(8):2231-2242.
  • Ortega-Molina A, Lopez-Guadamillas E, Mattison JA, Mitchell SJ, Muñoz-Martin M, Iglesias G, Gutierrez VM, Vaughan KL, Szarowicz MD, González-García I, López M, Cebrián D, Martinez S, Pastor J, de Cabo R, Serrano M. Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys. PMID: 25817535. Cell Metab. 2015 Apr 7;21(4):558-70.
  • Martínez de Morentin PB, Lage R, González-García I, Ruíz-Pino F, Martins L, Fernández-Mallo D, Gallego R, Fernø J, Señarís R, Saha AK, Tovar S, Diéguez C, Nogueiras R, Tena-Sempere M, López M. Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-CoA and the thermogenic effect of hypothalamic AMPK inhibition in female rats. PMID: 25535827. Endocrinology. 2015 Mar;156(3):947-60.
  • Fernø J, Ersland KM, Duus IH, González-García I, Fossan KO, Berge RK, Steen VM, Skrede S. Olanzapine depot exposure in male rats: Dose-dependent lipogenic effects without concomitant weight gain. PMID: 25823694. Eur Neuropsychopharmacol. 2015 Jun;25(6):923 32.
  • Contreras C, González-García I, Martínez-Sánchez N, Seoane-Collazo P, Jacas J, Morgan DA, Serra D, Gallego R, Gonzalez F, Casals N, Nogueiras R, Rahmouni K, Diéguez C, López M. Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance. PMID: 25284795. Cell Rep. 2014 Oct 9;9(1):366-377.
  • Martínez de Morentin PB, González-García I, Martins L, Lage R, Fernández- Mallo D, Martínez-Sánchez N, Ruíz-Pino F, Liu J, Morgan DA, Pinilla L, Gallego R, Saha AK, Kalsbeek A, Fliers E, Bisschop PH, Diéguez C, Nogueiras R, Rahmouni K, Tena-Sempere M, López M. Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. PMID: 24856932. Cell Metab. 2014 Jul 1;20(1):41-53.

Investigadora líder

Ismael González García

Ismael González García

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